Nature Search

Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma

In this genomic analysis of peripheral blood samples of the phase 3 CheckMate-067 trial of ipilimumab (IPI) versus nivolumab (NIVO) versus ipilimumab and nivolumab (IPI-NIVO) in melanoma, the status of certain mitochondrial haplogroups in patients was associated therapeutic resistance to NIVO or IPI-NIVO, a finding validated in an independent cohort.

Kelsey R. Monson
Robert Ferguson
Tomas Kirchhoff
ResearchOpen Access05 Jun 2025
Nature Medicine

P: 1-12
An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma

Melanocytes can de-differentiate into neural crest cell (NCC)- like states during metastatic melanoma progression. Here the authors compare DNA methylation profiles of NCCs and melanocytes, as well as primary and metastatic patient tissues and identify that DNA methylation changes of NR2F2 isoform 2 influence cell state transitions and melanoma metastatic spread.

Veronica Davalos
Claudia D. Lovell
Eva Hernando
ResearchOpen Access04 Apr 2023
Nature Communications

Volume: 14, P: 1-16
The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity

Hockemeyer et al. demonstrate that HSF1 activation inhibits cytokine production and cytotoxic activity in NK cells to impair anti-tumour immune responses.

Kathryn Hockemeyer
Theodore Sakellaropoulos
Iannis Aifantis
Research02 Sept 2024
Nature Cell Biology

Volume: 26, P: 1734-1744
FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification

Aifantis and colleagues report that FBXW7α controls the heat-shock response pathway by targeting HSF1 for degradation. In melanoma FBXW7α deficiency leads to increased nuclear HSF1, and induction of a pro-invasive gene expression program.

Nikos Kourtis
Rana S. Moubarak
Iannis Aifantis
Research27 Feb 2015
Nature Cell Biology

Volume: 17, P: 322-332
BRAF mutation predicts sensitivity to MEK inhibition

David B. Solit
Levi A. Garraway
Neal Rosen
Research06 Nov 2005
Nature

Volume: 439, P: 358-362
Manipulation of hot carrier cooling dynamics in two-dimensional Dion–Jacobson hybrid perovskites via Rashba band splitting

Hybrid perovskite is a promising class of material for optoelectronic applications due to the slow hot-carrier cooling, yet the process is not well-understood in material with Rashba band splitting. Here, the authors reveal spin-flipping and spin-dependent scattering of hot electrons are responsible for accelerating the cooling at longer delays.

Jun Yin
Rounak Naphade
Omar F. Mohammed
ResearchOpen Access28 Jun 2021
Nature Communications

Volume: 12, P: 1-9
Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment

Pan-cancer single-cell and spatial transcriptomic profiling identifies recurrent gene modules that underlie a continuum of cancer cell states. Tumor microenvironment influences the occurrence of these states.

Dalia Barkley
Reuben Moncada
Itai Yanai
Research05 Aug 2022
Nature Genetics

Volume: 54, P: 1192-1201
Novel variants causing megalencephalic leukodystrophy in Sudanese families

Mutaz Amin
Cedric Vignal
Imen Dorboz
Research10 Sept 2021
Journal of Human Genetics

Volume: 67, P: 127-132
A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease

Currently, few mouse models exist to recapitulate human melanomagenesis. Here, the authors establish a c-Kit-CreER-driven model to target melanocyte stem cells (McSCs) and show that oncogenic McSCs give rise to epidermal melanoma that invade into the dermis, similar to human melanoma.

Qi Sun
Wendy Lee
Mayumi Ito
ResearchOpen Access04 Nov 2019
Nature Communications

Volume: 10, P: 1-16
Genetic markers of pigmentation are novel risk loci for uveal melanoma

Robert Ferguson
Matjaz Vogelsang
Tomas Kirchhoff
ResearchOpen Access08 Aug 2016
Scientific Reports

Volume: 6, P: 1-6
Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

Exosomes are extracellular vesicles that can favor tumor development and metastasis. Here, the authors show that cancer exosomes may also exert a suppressive function; in fact, exosomes from non-metastatic melanoma cells can lead to the recruitment of patrolling monocytes, which clear cancer cells at the pre-metastatic niche.

Michael P. Plebanek
Nicholas L. Angeloni
Olga V. Volpert
ResearchOpen Access06 Nov 2017
Nature Communications

Volume: 8, P: 1-12
Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment

Spatiotemporal characterization of microbial diversity and antibiotic resistance in a tertiary-care hospital reveals broad distribution and persistence of antibiotic-resistant organisms that could cause opportunistic infections in a healthcare setting.

Kern Rei Chng
Chenhao Li
Niranjan Nagarajan
ResearchOpen Access08 Jun 2020
Nature Medicine

Volume: 26, P: 941-951
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

The histone variant mH2A is shown to be expressed at reduced levels in many melanomas. Loss of mH2A promotes tumour growth and metastasis via transcriptional upregulation of CDK8, a known oncogene. This study therefore reveals a new tumour suppression mechanism exerted by epigenetic modifications.

Avnish Kapoor
Matthew S. Goldberg
Emily Bernstein
Research22 Dec 2010
Nature

Volume: 468, P: 1105-1109
Radius-optimized efficient template matching for lesion detection from brain images

Subhranil Koley
Pranab K. Dutta
Iman Aganj
ResearchOpen Access02 Jun 2021
Scientific Reports

Volume: 11, P: 1-21
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

Trever Bivona and colleagues show that the Hippo pathway effector YAP promotes resistance to RAF and MEK inhibitor therapy in multiple types of BRAF-mutant tumors. The findings suggest that combined suppression of YAP and RAF-MEK signaling might enhance treatment response and prevent drug resistance.

Luping Lin
Amit J Sabnis
Trever G Bivona
Research09 Feb 2015
Nature Genetics

Volume: 47, P: 250-256
The mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrence

Roy Rabbie
Peter Ferguson
David J. Adams
ResearchOpen Access07 Oct 2020
British Journal of Cancer

Volume: 124, P: 156-160
Tissue microarrays, tread carefully

Luis Chiriboga
Iman Osman
Christie Lau
Correspondence15 Nov 2004
Laboratory Investigation

Volume: 84, P: 1677
Optimization of an automated tumor-infiltrating lymphocyte algorithm for improved prognostication in primary melanoma

Margaret Chou
Irineu Illa-Bochaca
Hua Zhong
Research01 Oct 2020
Modern Pathology

Volume: 34, P: 562-571
Immunomodulatory germline variation associated with the development of multiple primary melanoma (MPM)

Robert Ferguson
Alexi Archambault
Tomas Kirchhoff
ResearchOpen Access15 Jul 2019
Scientific Reports

Volume: 9, P: 1-8
Pathways for Modulating Exosome Lipids Identified By High-Density Lipoprotein-Like Nanoparticle Binding to Scavenger Receptor Type B-1

Nicholas L. Angeloni
Kaylin M. McMahon
C. Shad Thaxton
ResearchOpen Access11 Mar 2016
Scientific Reports

Volume: 6, P: 1-13
Epidermal growth factor receptor activation in prostate cancer by three novel missense mutations

C Q Cai
Y Peng
P Lee
Research14 Jan 2008
Oncogene

Volume: 27, P: 3201-3210
Computer-assisted measurement of primary tumor area is prognostic of recurrence-free survival in stage IB melanoma patients

Brooke E Rosenbaum
Christine N Schafer
Nooshin Brinster
Research21 Jul 2017
Modern Pathology

Volume: 30, P: 1402-1410
Immune response in melanoma: an in-depth analysis of the primary tumor and corresponding sentinel lymph node

Michelle W Ma
Ratna C Medicherla
Farbod Darvishian
Research16 Mar 2012
Modern Pathology

Volume: 25, P: 1000-1010

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