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Architecture, dynamics and biogenesis of GluA3 AMPA glutamate receptors

Aditya Pokharna
Imogen Stockwell
Ingo H. Greger
ResearchOpen Access01 Jul 2025
Nature

P: 1-3
Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization

Combining patch-clamp electrophysiology, molecular dynamics simulations, cryo-electron microscopy and imaging of neuronal synapses, the authors reveal how AMPA glutamate receptors are regulated by protons that are released from synaptic vesicles during signal transmission.

Josip Ivica
Nejc Kejzar
Ingo H. Greger
ResearchOpen Access13 Aug 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1601-1613
Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor

Calcium-permeable GluA1 AMPA glutamate receptors are structurally and functionally distinct from the prototypical GluA2-containing AMPA receptors, impacting their role in signal transmission, synaptic plasticity and learning.

Danyang Zhang
Josip Ivica
Ingo H. Greger
ResearchOpen Access13 Sept 2023
Nature

Volume: 621, P: 877-882

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