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Showing 1–4 of 4 results
Advanced filters: Author: Inna Averbukh Clear advanced filters

  • A multiomics approach is used to produce a spatiotemporal atlas of the human maternal–fetal interface in the first half of pregnancy, revealing relationships among gestational age, extravillous trophoblasts and spiral artery remodelling.

    • Shirley Greenbaum
    • Inna Averbukh
    • Michael Angelo
    ResearchOpen Access
    Nature
    Volume: 619, P: 595-605

  • Combining scRNA-seq with spatial information to enable the reconstruction of spatially-resolved cell atlases is challenging for rare cell types. Here the authors present ClumpSeq, an approach for sequencing small clumps of tissue attached cells, and apply it to establish spatial atlases for all secretory cell types in the small intestine.

    • Rita Manco
    • Inna Averbukh
    • Shalev Itzkovitz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Epithelial gene expression has been shown to be zonated along the crypt-villus axis, but mechanisms shaping this spatial variability were unknown. Here, Bahar Halpern et al. uncover zonation of mesenchymal cells, including Lgr5+ telocytes, which regulate epithelial gene expression at the villus tip.

    • Keren Bahar Halpern
    • Hassan Massalha
    • Shalev Itzkovitz
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Harnik and Buchauer et al. identify spatial discordances between enterocyte mRNA and protein levels along the villi of the small intestine, and provide a spatial blueprint of proteins in the intestinal epithelium.

    • Yotam Harnik
    • Lisa Buchauer
    • Shalev Itzkovitz
    Research
    Nature Metabolism
    Volume: 3, P: 1680-1693