During mouse gastrulation the primitive streak is an area of cell division and epithelial-to-mesenchymal transition, though how mitoses and cell delamination are linked is not clear. Here they show that a faster cell cycle and relaxation of the actomyosin cytoskeleton result in the occurrence of non-apical mitosis, which favors cell delamination.
- Evangéline Despin-Guitard
- Viviane S. Rosa
- Isabelle Migeotte