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Clock precision is thought to be fundamentally limited by entropy production in out-of-equilibrium systems. A theoretical work now introduces a quantum clock design where precision grows exponentially with dissipation.

LIM ___domain kinases are key regulators of cofilin and consequently actin severing. Here, the authors show that the LIMK PDZ ___domain is important for autoregulation using a conserved surface distal to the canonical PDZ-binding cleft.

Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the variation in clonal architecture within and between individuals.

Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.

The poor stability of narrow bandgap lead-tin perovskites hinders their implementation in multi junction cells. Here, the authors reveal that device performance degradation is caused by an increase in either mobile ion or background hole density, depending on the hole transport material used.

A multi-modal analysis of pre-metastatic liver biopsies from patients with localized pancreatic cancer with a minimum of 3 years of follow-up shows that immunological, proliferative and metabolomic features distinguish patients who develop metastases from disease-free survivors and can be used to predict outcomes.

Super spreading events are considered important contributors to the spread of COVID−19, but the extent to which superspreading varies by transmission setting is unclear. Here, the authors demonstrate heterogeneity in superspreading and the generation interval between COVID−19 cases in different settings using data from Hong Kong.

Here, the authors show that post-translational molecular signatures of human skeletal muscle in response to acute or chronic aerobic and resistance exercise are distinct, potentially dictating the differential physiologic adaptations to different exercise modes.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Polaritons and spontaneous parametric down conversion represent two hallmarks of the quantum nature of light-matter interaction which are poorly understood in the X-ray regime. Here, the authors experimentally resolve the signal cone of X-ray parametric down conversion, providing evidence of polariton formation at extreme ultraviolet wavelengths.

The researchers demonstrate direct measurement and complete characterization of structured electronic wave packets created within a prototypical Fano resonance. The method may be broadly applicable to the study of ultrafast processes, especially electronic ones, in complex systems, as well as coherent control of such systems on their fundamental timescales.

Tabletop quantum simulators have arisen as a powerful and highly configurable tool to study dynamics in quantum many-body systems. In this work, the authors propose an advancement of an existing optical-lattice setup for simulating lattice quantum electrodynamics to two spatial dimensions, and demonstrate its fidelity using numerical simulations.

Mycetoma is a chronic granulomatous infection of the subcutaneous tissue, most often caused by the fungal pathogen Madurella mycetomatis. Here, the authors show that iron acquisition pathways in both pathogen and host are upregulated during grain formation in an insect larva infection model.

Gupta, Johnson et al. quantify the turnover rates of ~3200 E. coli proteins, demonstrating that cytoplasmic proteins are recycled when nitrogen is limited and that protein degradation rates are generally uncoupled from cell division rates.

CMOS-based circuits can be integrated with silicon-based spin qubits and can be controlled at milli-kelvin temperatures, which can potentially help scale up these systems.

During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent degradation.

Analyzing readouts of inflammaging across four cohorts, Franck and colleagues identify strong variation and observe that inflammaging, in its known form, primarily emerges in industrialized—but not nonindustrialized—populations.

The dynamics of most nanomachines are stochastic, activated by thermal fluctuations. Here, authors find that, when two such nanomachines are mechanically coupled to each other, their dynamics can become almost deterministic, as they activate each other without the need for thermal fluctuations.

This study uncovered genetic associations with environmental sensitivity in psychiatric and neurodevelopmental traits in an international collaboration using data from more than 21,000 monozygotic twins—the largest genetic study of monozygotic twin differences to date.

Here, the authors show that cytoplasmic uridylyltransferases TUT7 and TUT4 bind let-7 pre-miRNA by alternative means in the absence and presence of Lin28A, which directly interacts with both RNA and enzyme to convert from a distributive to a processive mode of action.

Here the authors show that PD-1 controls coinhibitory receptor expression by T_reg cells. The absence of PD-1 expression could induce CD30 expression, thereby enhancing T_reg function and tumor escape, suggesting that CD30 might be a therapeutic target in cases of anti-PD-1 resistance.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to provide evidence of variant pathogenicity.

In this study, the authors develop a comprehensive taxonomy of brain-wide SPNs, identifying several novel subsets via their transcriptional signatures.

Recently, there has been great interest in studying plasmons in strange metals characterized by linear-in-temperature electrical resistivity. Schultz et al. report an EELS in transmission study of plasmons in Sr₂RuO₄, revealing unrenormalized behavior explained by resilient quasi-particles at high plasmon energy.

Liu et al. developed a platform to identify transcription factors (TFs) that turn stem cells into desired cell types. They discovered six key TFs that produce microglia efficiently, enhancing cell differentiation methods.

The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.

A 50 microRNA-based dynamic risk score for stratifying individuals with and without type 1 diabetes was developed using samples obtained from multicenter and multiethnic cohorts.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

The authors show that the cell-penetrating peptide DG9 enhances PMO delivery to skeletal and cardiac muscles via multiple endocytic pathways. DG9-PMO significantly boosts dystrophin restoration and cardioprotection, addressing a key challenge in the therapy of Duchenne muscular dystrophy.

LIM-___domain-only (LMO) proteins are a subset of the LIM-___domain protein family and function primarily as transcriptional regulators. They are associated with various cancers, including T cell acute lymphoblastic leukaemia (T-ALL) that resulted from unintended activation ofLMO2by insertional mutagenesis in human gene therapy trials. This Review discusses the roles and potential mechanisms of LMO proteins in cancer and the potential for therapeutic targeting.

Filamin C is a key actin-binding protein involved in cardiomyopathies and musculoskeletal disorders. Here, Wang et al reveal that it interacts with the heat shock protein HSPB7 under biomechanical stress, forming a stable hetero-dimer which is regulated by phosphorylation.

Neagu, van Genderen and Escudero et al. show that simultaneous inhibition of WNT and MEK signalling maintains a naive-primed intermediate pluripotency state in vitro, which displays features of the mouse embryonic rosette.

A wearable device measures parenchymal resistance and its dynamic relationship with sleep MRI measures of glymphatic function, EEG features and cardiovascular parameters in humans.

Inherent limitations on continuously measured quantum systems calls into question whether they could even in principle be used for online learning. Here, the authors experimentally demonstrate a quantum machine learning framework for inference on streaming data of arbitrary length, and provide a theory with criteria for the utility of their algorithm for inference on streaming data.

This study shows that the predictability of Central Pacific ENSO will be suppressed in response to global warming, driven by the faster warming over surface ocean in tropical Pacific and a consequent enhanced thermodynamical damping.

Although Li-rich layered oxides are attractive electrode materials for batteries, they suffer from voltage decay on cycling. A correlation between trapped metal ions in interstitial tetrahedral sites and voltage decay is established, which could prove useful for developing high-capacity electrodes without decay.