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Showing 1–5 of 5 results

Advanced filters: Author: Jacob Bobonis Clear advanced filters

Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection

Using the proteome-wide pSILAC-AHA labelling approach, the authors resolve the host proteome spatiotemporal dynamics during macrophage infection with Salmonella enterica Typhimurium and reveal the active role of cathepsins in cell death via the non-canonical inflammasome.

Joel Selkrig
Nan Li
Athanasios Typas
Research08 Jun 2020
Nature Microbiology

Volume: 5, P: 1119-1133
The functional proteome landscape of Escherichia coli

Thermal proteome profiling combined with a reverse genetics approach provides insights into the abundance and thermal stability of the global proteome of Escherichia coli.

André Mateus
Johannes Hevler
Mikhail M. Savitski
Research09 Dec 2020
Nature

Volume: 588, P: 473-478
Bacterial retrons encode phage-defending tripartite toxin–antitoxin systems

Retron-Sen2 of Salmonella Typhimurium encodes a toxin and a reverse transcriptase, which, together with the Sen2 multi-copy single-stranded DNA synthesized by the reverse transcriptase make up a tripartite toxin–antitoxin system that functions in anti-phage defence.

Jacob Bobonis
Karin Mitosch
Athanasios Typas
Research18 Jul 2022
Nature

Volume: 609, P: 144-150
TAC–TIC, a high-throughput genetics method to identify triggers or blockers of bacterial toxin–antitoxin systems

This protocol describes toxin activation–inhibition conjugation (TAC–TIC), a reverse genetics screening approach that can be used to identify triggers or blockers of bacterial toxin–antitoxin or phage immunity systems.

Jacob Bobonis
Alessio Ling Jie Yang
Athanasios Typas
Protocols09 May 2024
Nature Protocols

Volume: 19, P: 2231-2249
Species-specific activity of antibacterial drug combinations

Screening pairwise combinations of antibiotics and other drugs against three bacterial pathogens reveals that antagonistic and synergistic drug–drug interactions are specific to microbial species and strains.

Ana Rita Brochado
Anja Telzerow
Athanasios Typas
Research04 Jul 2018
Nature

Volume: 559, P: 259-263