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Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype

Senescent cells accumulate during aging and exhibit cell enlargement, the function of which has been unclear for decades. Here, the authors identify an antagonistic genetic circuit for hypertrophy and reveal its instructive role in modulating the SASP.

Joae Joung
Yekang Heo
Chanhee Kang
ResearchOpen Access17 Feb 2025
Nature Communications

Volume: 16, P: 1-19
Correction: Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

Jae Myoung Suh
Johan W. Jonker
Ronald M. Evans
Amendments and Corrections04 Mar 2015
Nature

Volume: 520, P: 388
Hippo–YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

The transcriptional coregulators YAP/TAZ are shown to directly control leptin gene transcription, thereby uncoupling adipose tissue mass from leptin levels.

Sungwoo Choi
Ju-Gyeong Kang
Jae Myoung Suh
ResearchOpen Access29 May 2024
Nature Metabolism

Volume: 6, P: 847-860
Therapeutic effects of lomerizine on vasculopathy in Fabry disease

Jong Bin Choi
Hyo-Sang Do
Yong-Mahn Han
ResearchOpen Access02 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis

The development of a transgenic mouse line that expresses mitochondrial matrix-targeted APEX2 combined with proteome analysis identified RTN4IP1, which serves as an NAD(P)H oxidoreductase required for respiration and CoQ biosynthesis.

Isaac Park
Kwang-eun Kim
Hyun-Woo Rhee
ResearchOpen Access26 Oct 2023
Nature Chemical Biology

Volume: 20, P: 221-233
Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial role for it in maintaining brown adipocyte mitochondrial OXPHOS and thermogenesis upon cold stimulus.

Anna Park
Kwang-eun Kim
Jae Myoung Suh
ResearchOpen Access23 Jun 2023
Nature Communications

Volume: 14, P: 1-14
A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

PPARγ induces fibroblast growth factor 1 to remodel visceral adipose tissue in response to a high-fat diet to maintain metabolic homeostasis.

Johan W. Jonker
Jae Myoung Suh
Ronald M. Evans
Research22 Apr 2012
Nature

Volume: 485, P: 391-394
Reduced graphene oxide enwrapped phosphors for long-term thermally stable phosphor converted white light emitting diodes

Gopinathan Anoop
Janardhanan R. Rani
Jae Soo Yoo
ResearchOpen Access27 Sept 2016
Scientific Reports

Volume: 6, P: 1-9
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

Pharmacological fibroblast growth factor 1 (FGF1) normalizes blood glucose in diabetic mice by means of an FGF receptor signalling pathway that is independent of its mitogenic activity.

Jae Myoung Suh
Johan W. Jonker
Ronald M. Evans
Research16 Jul 2014
Nature

Volume: 513, P: 436-439
Publisher Correction: Serotonin signals through a gut-liver axis to regulate hepatic steatosis

Wonsuk Choi
Jun Namkung
Hail Kim
Amendments and CorrectionsOpen Access08 Jan 2019
Nature Communications

Volume: 10, P: 1
Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain

Yeom et al. demonstrate that tumour cell-secreted Dilp8/INSL3 activates Lgr3 signalling and modulates expression of distinct feeding hormones such as NUCB1 and sNPF, thereby inducing anorexia in cancer.

Eunbyul Yeom
Hyemi Shin
Kweon Yu
Research08 Feb 2021
Nature Cell Biology

Volume: 23, P: 172-183
Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice

The in vivo identification of proteins secreted from a specific cell type or tissue remains challenging. Here, the authors develop a proximity labeling-based method to selectively label secreted proteins and combine it with proteomics to identify liver secretory proteins in mouse plasma.

Kwang-eun Kim
Isaac Park
Jae Myoung Suh
ResearchOpen Access01 Sept 2021
Nature Communications

Volume: 12, P: 1-9
Serotonin signals through a gut-liver axis to regulate hepatic steatosis

No effective pharmacological treatments exist for nonalcoholic fatty liver disease (NAFLD). Here, the authors show that serotonin concentration in the portal blood is increased in nine human subjects and in mice fed a high-fat diet, and that local serotonin signaling ablation, either genetically or with an antagonist, prevents hepatic steatosis in mice.

Wonsuk Choi
Jun Namkung
Hail Kim
ResearchOpen Access16 Nov 2018
Nature Communications

Volume: 9, P: 1-9
Obesity alters pathology and treatment response in inflammatory disease

Obesity changes the characteristics of the immune response induced in a mouse model of atopic dermatitis, suggesting therapies that could be used against immune dysregulation in obesity.

Sagar P. Bapat
Caroline Whitty
Alexander Marson
Research30 Mar 2022
Nature

Volume: 604, P: 337-342
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Restriction of FXR agonism to the gut improves obesity and diabetes.

Sungsoon Fang
Jae Myoung Suh
Ronald M Evans
Research05 Jan 2015
Nature Medicine

Volume: 21, P: 159-165
Depletion of fat-resident T_reg cells prevents age-associated insulin resistance

Fat-resident regulatory T cells (fT_reg cells) accumulate in adipose tissue of mice as a function of age, but not obesity; mice without fT_reg cells are protected against age-associated insulin resistance, but remain susceptible to obesity-associated insulin resistance and metabolic disease, indicating different aetiologies of age-associated versus obesity-associated insulin resistance.

Sagar P. Bapat
Jae Myoung Suh
Ye Zheng
Research18 Nov 2015
Nature

Volume: 528, P: 137-141
P53 mediates ceramide-induced apoptosis in SKN-SH cells

Sung Su Kim
Hee-Sun Chae
Yoo-Hun Suh
Research22 Mar 2002
Oncogene

Volume: 21, P: 2020-2028
PPARγ signaling and metabolism: the good, the bad and the future

Thiazolidinediones (TZDs), which act through the nuclear receptor peroxisome proliferator activated receptor-γ (PPARγ), are a widely prescribed class of drugs for type 2 diabetes; however, their use has been challenged by a number of side effects. Here the authors outline recent advances in our understanding of the modulation of the PPARγ pathway in metabolism and discuss how these insights might be used to explain the adverse side effects of TZD therapy and develop a new generation of safer PPARγ-targeting drugs.

Maryam Ahmadian
Jae Myoung Suh
Ronald M Evans
Reviews07 May 2013
Nature Medicine

Volume: 19, P: 557-566
Synergistic actions of FGF2 and bone marrow transplantation mitigate radiation-induced intestinal injury

Byoung Hyuck Kim
Hee-Won Jung
Jae Myoung Suh
ResearchOpen Access07 Mar 2018
Cell Death & Disease

Volume: 9, P: 1-12

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