Search

The real business of decarbonization begins after an agreement is signed at the Paris climate conference, argue David G. Victor and James P. Leape.

Rigorous measurement of adaptation policies is crucial to implementing successful climate policy. Policy analysis of 41 countries shows an 87% increase in adaptation initiatives since 2010, suggesting that concrete adoption of such practices is growing.

For the first time in 2024, the Astronomical Society of Australia Annual Scientific Meeting was held as an online-first conference, incorporating unprecedented use of immersive spatial venues. This Comment presents findings from this experiment in accessible conferencing and reflects on their implications in the current academic climate.

Over the last decade, significant attention has been drawn to the gender ratio of speakers at conferences, with ongoing efforts for meetings to better reflect the gender representation in the field. We find that women are significantly under-represented, however, among the astronomers asking questions after talks.

Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or pathological Aβ has differing effects on synapses in live human brain slice cultures.

Our voices were crucial in persuading UN states to back legal obligations to act on climate change. Here’s how we did it.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

If your institution won’t break down barriers for you, do it yourself, say Tom Logan and James Arnott.

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

The authors document wide variation in information density and speed of communication across the world’s languages. They find that higher-density languages communicate information more quickly but with more sustained focus than lower-density languages.

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Welcome to Melbourne, where science is fuelled by a better class of coffee.

Scientists have reacted to COVID-19 restrictions by organizing virtual seminars and journal clubs to maintain engagement. The authors reflect on their experiences and lessons learned from organizing such initiatives and highlight how, far from being temporary substitutes of in-person counterparts, they can help foster more diverse, inclusive and environmentally friendly scientific exchange.

Cancer stem cells (CSCs) are associated with chemoresistance and poor prognosis in multiple cancer types. Here, the authors investigate the role of secreted Wnt ligands in pancreatic and breast CSCs and identify E2F1/4-GCN5-pRb/RBL2 as a regulatory axis underlying Wnt secretion.

The XXXII IAU General Assembly, held for the first time on the African continent from 6–15 August 2024, marked a historic milestone in the global astronomy community. Driven by a bold vision, the event highlighted Africa's growing scientific capacity, and embodied the African spirit of Ubuntu, emphasizing accessibility, impact, and sustainability.

For a third year in a row, we followed up with authors of several recent Comments and Perspectives in Nature Machine Intelligence about what happened after their article was published: how did the topic they wrote about develop, did they gain new insights, and what are their hopes and expectations for AI in 2022?

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Investigation of variation in three cohorts has identified multiple genetic signals associated with the pregnancy-specific liver disorder, intrahepatic cholestasis of pregnancy, giving insight into the disease which can cause preterm birth and stillbirth.

Researchers are increasingly toying with the idea of taking their ideas out of universities and into the marketplace. Starting your own company can be extremely rewarding, but it requires perseverance and a great deal of hard work.

José Miguel Bermúdez Menéndez, energy technology analyst on hydrogen and alternative fuels at the International Energy Agency (IEA), talks to Nature Energy about the IEA’s Hydrogen Projects Database, which was last updated in October 2022.

The authors study tunneling junctions in rhombohedral MoS₂ bilayers and correlate their performance with the local ___domain layout. They show that the switching behavior in sliding ferroelectrics is strongly dependent on the pre-existing ___domain structure.

Quantum simulation of superfluid to Mott insulator transition in twisted-bilayer square lattices based on atomic Bose–Einstein condensates loaded into spin-dependent optical lattices provides a new direction for exploring moiré physics in ultracold atoms.

In a single-arm phase 2 trial evaluating intravesical delivery of the oncolytic adenovirus cretostimogene grenadenorepvec with systemic anti-PD-1 in patients with BCG-unresponsive non-muscle-invasive bladder cancer with carcinoma in situ, the complete response rate at 12 months was 57.1%, meeting the primary endpoint.

Cellular overgrowth and fibrosis in the foreign body response can compromise the function of transplanted cells. Here, the authors report on the zwitterionically modified alginates for the encapsulation of cells to reduce cellular overgrowth and demonstrate application in mice, dogs and pigs.

A longitudinal evolutionary analysis of 126 lung cancer patients with metastatic disease reveals the timing of metastatic divergence, modes of dissemination and the genomic events subject to selection during the metastatic transition.

Analyses of multiregional tumour samples from 421 patients with non-small cell lung cancer prospectively enrolled to the TRACERx study reveal determinants of tumour evolution and relationships between intratumour heterogeneity and clinical outcome.

In August 2024, the International Astronomical Union General Assembly was held for the first time on the African continent, as a fully hybrid and open-access conference. This opportunity to approach such a traditional and historical event from a new perspective encouraged a spirit of innovation enabled by emerging technologies.

Biennials, regional hubs and virtual attendance can slash emissions, new calculations show.

An optical pooled cell profiling platform (PERISCOPE) based on Cell Painting and optical sequencing of molecular barcodes was used to develop the first unbiased genome-wide morphology-based perturbation atlas in human cells.

High-fat diet plays a role in development of insulin resistance. Here, the authors report a mechanism that underlies the development of diet induced insulin resistance through the activation of an aryl hydrocarbon receptor mediated signalling pathway in the liver by faecal exosomes derived from intestinal cells.

Nancy Ryan Gray, President and Chief Executive Officer of the Gordon Research Conferences (GRC), talks to Nature Energy about her career and The GRC Power Hour, a forum for discussions about inclusivity within the scientific community.

Greater global cooperation is needed to avert the risk of further militarization, says James Clay Moltz.