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Showing 1–4 of 4 results
Advanced filters: Author: Jamie A. Moroco Clear advanced filters

  • In this work, the authors report a sophisticated combination of genetic, biophysical, and biochemical analyses to identifies the cycling conformational states of PPM1D. The findings reveal how an allosteric inhibitor locks the protein into a conformationally inactive state, and explain the distribution of PPM1D activating mutations in cancer.

    • Peter G. Miller
    • Murugappan Sathappa
    • Benjamin L. Ebert
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Prew et al. uncovered a structural basis for human VLCAD deficiency that arises from point mutations within the enzyme’s membrane-binding region, which was shown to fold as a putative α-helical hairpin. Helix-breaking mutations selectively disrupt membrane interaction and thus homeostatic function.

    • Michelle S. Prew
    • Christina M. Camara
    • Loren D. Walensky
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The interplay of the proteasome and deubiquitinase Ubp6 is crucial for the degradation of ubiquitylated substrates. Here, the authors provide structural insights into the allosteric mechanism by which the activities of both Ubp6 and the proteasome are regulated.

    • Ka Ying Sharon Hung
    • Sven Klumpe
    • Daniel Finley
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13