Nature Search

Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons

Karolina Worf
Natalie Matosin
Janine Knauer-Arloth
ResearchOpen Access19 Apr 2025
Translational Psychiatry

Volume: 15, P: 1-13
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice

Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognition via TCF4.

Lotte van Doeselaar
Alexandra Abromeit
Mathias V. Schmidt
ResearchOpen Access14 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease

Single-cell profiling in the human cortex reveals aging-associated transcriptomic changes across all brain cell types, which overlap with effects with Alzheimer’s disease and show a convergent signature with psychopathology across multiple cell types.

Anna S. Fröhlich
Nathalie Gerstner
Elisabeth B. Binder
ResearchOpen Access03 Sept 2024
Nature Neuroscience

Volume: 27, P: 2021-2032
Stress-induced brain responses are associated with BMI in women

In humans, brain responses to stress are associated with their body mass index, driven mostly by females. Predictive modeling showed that this link was better explained by changes in endocrine instead of immune systems.

Anne Kühnel
Jonas Hagenberg
Nils B. Kroemer
ResearchOpen Access11 Oct 2023
Communications Biology

Volume: 6, P: 1-15
Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature

Christopher R. Brydges
Oliver Fiehn
Piero Rinaldo
ResearchOpen Access25 Oct 2021
Scientific Reports

Volume: 11, P: 1-14
Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression

Siamak MahmoudianDehkordi
Ahmed T. Ahmed
Ranga Krishnan
ResearchOpen Access02 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-14

Quick links

Search

Filter By:

Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons

FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice

Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease

Stress-induced brain responses are associated with BMI in women

Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature

Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression

Search

Quick links