Nature Search

Phosphoproteomics-directed manipulation reveals SEC22B as a hepatocellular signaling node governing metabolic actions of glucagon

Glucagon is hormone that signals via a dedicated g-protein coupled receptor, but downstream signaling is poorly understood. Here, Wu et al. uncover liver glucagon signaling using phosphoproteomics and define a role for the vesicle trafficking protein SEC22B in distinct metabolic actions.

Yuqin Wu
Ashish Foollee
Adam J. Rose
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-17
Proteoform profiling of endogenous single cells from rat hippocampus at scale

Proteoforms from 10,000 rat single-brain cells are captured directly at high throughput.

Pei Su
Michael A. R. Hollas
Neil L. Kelleher
Research15 May 2025
Nature Biotechnology

P: 1-5
Ichthyology: Filter-feeding on a grand scale

Jared M. Diamond
News & Views22 Aug 1985
Nature

Volume: 316, P: 679-680
Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18

Intramyocardial injection of synthetic mRNA coding for the embryonic T-box transcription factor 18 gene generates rate-adaptive cardiac pacing and limits innate and inflammatory immune responses, as shown in rodents and pigs.

David W. Wolfson
Nam Kyun Kim
Hee Cheol Cho
ResearchOpen Access02 May 2024
Nature Biomedical Engineering

Volume: 8, P: 1124-1141
Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Increasing the supply of growth machinery to axons is a potential strategy for promoting repair after injury. Here the authors demonstrate that the endoplasmic reticulum adaptor molecule Protrudin provides cellular components that support axonal regeneration in the adult CNS.

Veselina Petrova
Craig S. Pearson
James W. Fawcett
ResearchOpen Access05 Nov 2020
Nature Communications

Volume: 11, P: 1-15
Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys

Targeted drug delivery in vivo is a complex challenge, and understanding the characteristics that define the behavior of delivery vehicles in vivo is vital for advancing delivery vehicle design. Here the authors use a library of polymeric delivery vehicles and high-throughput tools to study the structure-function relationships guiding the physiological fate of nanomedicines.

Alexandra S. Piotrowski-Daspit
Laura G. Bracaglia
W. Mark Saltzman
ResearchOpen Access18 May 2024
Nature Communications

Volume: 15, P: 1-15
Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides

Collagen denaturation is thought to occur during tissue mechanical damage, but its role in damage initiation is still unclear. Here, the authors use a collagen hybridizing peptide to provide insights into the molecular mechanisms leading to collagen unfolding during tendon mechanical stretch.

Jared L. Zitnay
Yang Li
Jeffrey A. Weiss
ResearchOpen Access22 Mar 2017
Nature Communications

Volume: 8, P: 1-12
Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

Regeneration and plasticity after spinal cord injury are limited by inhibitory proteoglycans; here, modulation of a receptor for proteoglycans in rats is shown to lead to functional recovery after injury.

Bradley T. Lang
Jared M. Cregg
Jerry Silver
Research03 Dec 2014
Nature

Volume: 518, P: 404-408
Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons

In this study, the authors use selective silencing of specific subsets of afferent neurons and stimulation with pruritogens or algogens to show that histaminergic and non-histaminergic itch is mediated by functionally distinct sets of sensory fibers. These findings provide further evidence for the labeled line theory of sensory perception.

David P Roberson
Sagi Gudes
Clifford J Woolf
Research19 May 2013
Nature Neuroscience

Volume: 16, P: 910-918
Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells

The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells, independent of mouse strain or mutational status.

Angela M. Lager
Olivia G. Corradin
Paul J. Tesar
ResearchOpen Access13 Sept 2018
Nature Communications

Volume: 9, P: 1-8
Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications

Monitoring neuronal activity in the rodent in vivobrain is commonly done using micro-electrode arrays but these devices are not normally compatible with optical technologies. Here the authors design a transparent and flexible electrode array based on graphene that allows them to combine electrophysiological recordings with optogenetic and imaging experiments.

Dong-Wook Park
Amelia A. Schendel
Justin C. Williams
ResearchOpen Access20 Oct 2014
Nature Communications

Volume: 5, P: 1-11
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans

This study describes a series of new gene-regulatory sequences that restrict expression of viral transgenes to specific interneuron subtypes, allowing for selective monitoring and manipulation of their activity from mice to humans.

Douglas Vormstein-Schneider
Jessica D. Lin
Jordane Dimidschstein
Research17 Aug 2020
Nature Neuroscience

Volume: 23, P: 1629-1636
Cerebrospinal fluid solute transport associated with sensorimotor brain activity in rodents

Evgenii Kim
Jared Van Reet
Seung-Schik Yoo
ResearchOpen Access09 Oct 2023
Scientific Reports

Volume: 13, P: 1-11
Non-invasive enhancement of intracortical solute clearance using transcranial focused ultrasound

Seung-Schik Yoo
Evgenii Kim
Kyungho Yoon
ResearchOpen Access31 Jul 2023
Scientific Reports

Volume: 13, P: 1-14
Photochemical activation of TRPA1 channels in neurons and animals

Optovin is a small molecule that renders zebrafish embryos responsive to light through generation of singlet oxygen and activation of the TrpA1b channel, providing a new tool for optogenetics.

David Kokel
Chung Yan J Cheung
Randall T Peterson
Research10 Feb 2013
Nature Chemical Biology

Volume: 9, P: 257-263
Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein

Joseph R. Patterson
Warren D. Hirst
Caryl E. Sortwell
ResearchOpen Access24 May 2022
npj Parkinson's Disease

Volume: 8, P: 1-14
Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition

Wajihah Mughal
Matthew Martens
Joseph W. Gordon
ResearchOpen Access06 Mar 2018
Cell Death & Differentiation

Volume: 25, P: 1732-1748
A Long-Term Pilot Study on Sex and Spinal Cord Injury Shows Sexual Dimorphism in Functional Recovery and Cardio-Metabolic Responses

Adel B. Ghnenis
Daniel T. Burns
Jared S. Bushman
ResearchOpen Access17 Feb 2020
Scientific Reports

Volume: 10, P: 1-10
Fabrication and utility of a transparent graphene neural electrode array for electrophysiology, in vivo imaging, and optogenetics

The protocol describes how to make transparent graphene neural electrodes for implantation onto the surface of the cerebral cortex in rodents and subsequent neural analysis by fluorescence microscopy, electrophysiology, optical coherence tomography, and optogenetics.

Dong-Wook Park
Sarah K Brodnick
Zhenqiang Ma
Protocols13 Oct 2016
Nature Protocols

Volume: 11, P: 2201-2222
Bortezomib-induced neuropathy is in part mediated by the sensitization of TRPV1 channels

An unbiased primary sensory neuron screen identifies the chemotherapeutic agent bortezomib as a potent TRPV1 sensitizer. Such long-term sensitization could lead to axonal death and sensory loss, a major symptom of bortezomib-induced neuropathy.

Jared M. Sprague
Ajay S. Yekkirala
Alban Latremoliere
ResearchOpen Access05 Dec 2023
Communications Biology

Volume: 6, P: 1-12
Divergent effects of acute and repeated quetiapine treatment on dopamine neuron activity in normal vs. chronic mild stress induced hypodopaminergic states

Jared L. Moreines
Zoe L. Owrutsky
Anthony A. Grace
ResearchOpen Access11 Dec 2017
Translational Psychiatry

Volume: 7, P: 1-10
Contribution of engineered nanomaterials physicochemical properties to mast cell degranulation

Monica M. Johnson
Ryan Mendoza
Jared M. Brown
ResearchOpen Access06 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
Transcranial focused ultrasound-mediated unbinding of phenytoin from plasma proteins for suppression of chronic temporal lobe epilepsy in a rodent model

Evgenii Kim
Hyun-Chul Kim
Wonhye Lee
ResearchOpen Access13 Mar 2023
Scientific Reports

Volume: 13, P: 1-15
Photoacoustic imaging for non-invasive assessment of biomarkers of intestinal injury in experimental necrotizing enterocolitis

Jared A. Weis
Jessica L. Rauh
Victoria G. Weis
ResearchOpen Access24 Jun 2024
Pediatric Research

Volume: 97, P: 169-177
Enhancement of cerebrospinal fluid tracer movement by the application of pulsed transcranial focused ultrasound

Seung-Schik Yoo
Hyun-Chul Kim
Kyungho Yoon
ResearchOpen Access28 Jul 2022
Scientific Reports

Volume: 12, P: 1-13
Involvement of Infralimbic Prefrontal Cortex but not Lateral Habenula in Dopamine Attenuation After Chronic Mild Stress

Jared L Moreines
Zoe L Owrutsky
Anthony A Grace
Research04 Nov 2016
Neuropsychopharmacology

Volume: 42, P: 904-913
Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3

Matthew D. Martens
Nivedita Seshadri
Joseph W. Gordon
ResearchOpen Access26 Nov 2021
Cell Death & Disease

Volume: 12, P: 1-16
A method for high-throughput functional imaging of single cells within heterogeneous cell preparations

Adam S. Neal
Austin M. Rountree
Ian R. Sweet
ResearchOpen Access16 Dec 2016
Scientific Reports

Volume: 6, P: 1-10
A new mild hyperthermia device to treat vascular involvement in cancer surgery

Matthew J. Ware
Lam P. Nguyen
Stuart J. Corr
ResearchOpen Access12 Sept 2017
Scientific Reports

Volume: 7, P: 1-14
Decoy peptide targeted to Toll-IL-1R ___domain inhibits LPS and TLR4-active metabolite morphine-3 glucuronide sensitization of sensory neurons

Yohance M. Allette
Youngsook Kim
Fletcher A. White
ResearchOpen Access16 Jun 2017
Scientific Reports

Volume: 7, P: 1-11
A mouse model of prenatal exposure to Interleukin-6 to study the developmental origin of health and disease

Tarak Srivastava
Trupti Joshi
Mukut Sharma
ResearchOpen Access24 Jun 2021
Scientific Reports

Volume: 11, P: 1-19

Search

Phosphoproteomics-directed manipulation reveals SEC22B as a hepatocellular signaling node governing metabolic actions of glucagon

Proteoform profiling of endogenous single cells from rat hippocampus at scale

Ichthyology: Filter-feeding on a grand scale

Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys

Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons

Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells

Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications

Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans

Cerebrospinal fluid solute transport associated with sensorimotor brain activity in rodents

Non-invasive enhancement of intracortical solute clearance using transcranial focused ultrasound

Photochemical activation of TRPA1 channels in neurons and animals

Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein

Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition

A Long-Term Pilot Study on Sex and Spinal Cord Injury Shows Sexual Dimorphism in Functional Recovery and Cardio-Metabolic Responses

Fabrication and utility of a transparent graphene neural electrode array for electrophysiology, in vivo imaging, and optogenetics

Bortezomib-induced neuropathy is in part mediated by the sensitization of TRPV1 channels

Divergent effects of acute and repeated quetiapine treatment on dopamine neuron activity in normal vs. chronic mild stress induced hypodopaminergic states

Contribution of engineered nanomaterials physicochemical properties to mast cell degranulation

Transcranial focused ultrasound-mediated unbinding of phenytoin from plasma proteins for suppression of chronic temporal lobe epilepsy in a rodent model

Photoacoustic imaging for non-invasive assessment of biomarkers of intestinal injury in experimental necrotizing enterocolitis

Enhancement of cerebrospinal fluid tracer movement by the application of pulsed transcranial focused ultrasound

Involvement of Infralimbic Prefrontal Cortex but not Lateral Habenula in Dopamine Attenuation After Chronic Mild Stress

Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3

A method for high-throughput functional imaging of single cells within heterogeneous cell preparations

A new mild hyperthermia device to treat vascular involvement in cancer surgery

Decoy peptide targeted to Toll-IL-1R ___domain inhibits LPS and TLR4-active metabolite morphine-3 glucuronide sensitization of sensory neurons

A mouse model of prenatal exposure to Interleukin-6 to study the developmental origin of health and disease

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