Nature Search

Brain organoid reservoir computing for artificial intelligence

An artificial intelligence hardware approach that uses the adaptive reservoir computation of biological neural networks in a brain organoid can perform tasks such as speech recognition and nonlinear equation prediction.

Hongwei Cai
Zheng Ao
Feng Guo
Research11 Dec 2023
Nature Electronics

Volume: 6, P: 1032-1039
Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease

Guttikonda et al. engineered a human pluripotent stem cell-derived tri-culture system containing microglia, astrocytes, and neurons. This system recapitulates cell-type-specific inflammatory signaling in an in vitro model of Alzheimer’s disease.

Sudha R. Guttikonda
Lisa Sikkema
Lorenz Studer
Research08 Feb 2021
Nature Neuroscience

Volume: 24, P: 343-354
Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development

Neuronal development is tightly controlled by nutrients and antioxidants. Here, authors show that ferroptosis, a cell death modality driven by lipid peroxidation, is required to be suppressed by vitamin A or antioxidants to ensure proper neuronal development.

Juliane Tschuck
Vidya Padmanabhan Nair
Kamyar Hadian
ResearchOpen Access01 Sept 2024
Nature Communications

Volume: 15, P: 1-14
Capturing the biology of disease severity in a PSC-based model of familial dysautonomia

Using induced pluripotent stem cells from patients with familial dysautonomia, the authors show that in vitro models can recapitulate patient-specific differences in disease severity.

Nadja Zeltner
Faranak Fattahi
Lorenz Studer
Research14 Nov 2016
Nature Medicine

Volume: 22, P: 1421-1427
Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

Cortical neurons are rapidly derived from human pluripotent stem cells using a cocktail of small molecules.

Yuchen Qi
Xin-Jun Zhang
Lorenz Studer
Research23 Jan 2017
Nature Biotechnology

Volume: 35, P: 154-163
NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells

A new method generates astrocytes from human pluripotent stem cells in 5 days.

Jason Tchieu
Elizabeth L. Calder
Lorenz Studer
Research25 Feb 2019
Nature Biotechnology

Volume: 37, P: 267-275
Specification of positional identity in forebrain organoids

Supplying forebrain organoids with a developmental signaling gradient induces topographical patterning along dorso-ventral and antero-posterior axes.

Gustav Y. Cederquist
James J. Asciolla
Lorenz Studer
Research01 Apr 2019
Nature Biotechnology

Volume: 37, P: 436-444
Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

A differentiation protocol to obtain enteric nervous system (ENS) progenitors and a range of neurons from human pluripotent stem cells is developed; the cells can migrate and graft to the colon of a chick embryo and an adult mouse colon, including in a mouse model of Hirschsprung disease, in which a functional rescue is observed.

Faranak Fattahi
Julius A Steinbeck
Lorenz Studer
Research10 Feb 2016
Nature

Volume: 531, P: 105-109

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