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Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening

Human brain organoids are plagued by heterogeneity and poor reproducibility, critical parameters for reliable disease modeling and drug testing. Here, the authors report on Hi-Q organoids which solve these limitations and can be cryopreserved in large quantities.

Anand Ramani
Giovanni Pasquini
Jay Gopalakrishnan
ResearchOpen Access19 Dec 2024
Nature Communications

Volume: 15, P: 1-20
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Author Correction: Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening

Anand Ramani
Giovanni Pasquini
Jay Gopalakrishnan
Amendments and CorrectionsOpen Access04 Feb 2025
Nature Communications

Volume: 16, P: 1
Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length

Centrioles and cilia are microtubule-based structures of defined architecture, but what regulates this architecture is not clear. Here the authors discover that centrosomal-P4.1-associated-protein (CPAP) binds the α/β-tubulin dimer and licenses it for tubulin delivery contributing to centriolar/ciliary length and architecture control.

Xiangdong Zheng
Anand Ramani
Haitao Li
ResearchOpen Access16 Jun 2016
Nature Communications

Volume: 7, P: 1-13
Pervasive structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs

By applying Hi-C to cells derived from the tumors of 24 GBM patients, the authors show pervasive structural variation in GBM chromosomal organization. How such patient-to-patient variation explains the characteristic gene expression patterns in each tumor is investigated.

Ting Xie
Adi Danieli-Mackay
Argyris Papantonis
ResearchOpen Access09 May 2024
Nature Communications

Volume: 15, P: 1-16
RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis

The RRP7A a gene is involved in ribosome biogenesis. Here the authors report a homozygous missense mutation segregating with primary microcephaly, and show that this occurs via functional defects in both nucleoli and primary cilia disrupting cell proliferation and neurogenesis.

Muhammad Farooq
Louise Lindbæk
Lars Allan Larsen
ResearchOpen Access16 Nov 2020
Nature Communications

Volume: 11, P: 1-16
Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial

In a single-arm, non-randomized trial, neoadjuvant atezolizumab therapy in a large cohort of patients with resectable non-small cell lung cancer was safe and the study met its primary end point of major pathological response ≥15%.

Jamie E. Chaft
Filiz Oezkan
Justin D. Blasberg
ResearchOpen Access12 Sept 2022
Nature Medicine

Volume: 28, P: 2155-2161
Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia

This protocol enables the generation of human forebrain organoids from induced pluripotent stem cells with the intrinsic ability to assemble functionally integrated bilateral optic vesicles.

Elke Gabriel
Walid Albanna
Jay Gopalakrishnan
Protocols17 May 2023
Nature Protocols

Volume: 18, P: 1893-1929
Trends and challenges in modeling glioma using 3D human brain organoids

Aruljothi Mariappan
Gladiola Goranci-Buzhala
Jay Gopalakrishnan
ReviewsOpen Access01 Dec 2020
Cell Death & Differentiation

Volume: 28, P: 15-23

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