A mouse model for familial adenomatous polyposis has been used to distinguish between possible mechanisms leading to loss of function of the Apc tumor-suppressor gene. Somatic recombination rather than chromosome loss associated with genetic instability is the primary cause of these cancers. Moreover, the data suggest that interphase nuclear architecture is a key factor in facilitating this process.
- Jay A. Tischfield
- Changshun Shao
