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Showing 1–9 of 9 results
Advanced filters: Author: Jayakrishnan Nandakumar Clear advanced filters

  • The freshwater planarian S. mediterranea is an important model organism for regeneration research but its use in aging research is little explored and S. mediterranea is commonly referred to as immortal. Here Dai et al. report age-associated physiological and molecular changes in the sexual lineage of S. mediterranea, and global reversal of such changes after regeneration.

    • Xiaoting Dai
    • Xinghua Li
    • Longhua Guo
    ResearchOpen Access
    Nature Aging
    Volume: 5, P: 780-798

  • Unicellular eukaryotes and mammalian germ cells and stem cells can maintain their telomere length through the action of telomerase. Insights into the mechanism by which telomerase is recruited to capped telomeres, and the individual contributions of telomere-associated proteins, highlight differences in this process between humans, budding yeast and fission yeast.

    • Jayakrishnan Nandakumar
    • Thomas R. Cech
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 14, P: 69-82

  • Structural and functional analyses of human TRF1 in complex with meiosis-specific protein TERB1 reveal the basis for telomere tethering to the inner nuclear membrane and offer insight into the mechanism of dissociation in late pachytene.

    • Devon F Pendlebury
    • Yasuhiro Fujiwara
    • Jayakrishnan Nandakumar
    Research
    Nature Structural & Molecular Biology
    Volume: 24, P: 1064-1072

  • Using separation-of-function mutations of TPP1 that inhibit telomerase binding while maintaining telomere capping, a region on the surface of TPP1, the TEL patch, is identified and found to be required for both binding telomerase and enhancing its processivity.

    • Jayakrishnan Nandakumar
    • Caitlin F. Bell
    • Thomas R. Cech
    Research
    Nature
    Volume: 492, P: 285-289