Many proteins have buried active sites in their folded states, which are only exposed when the protein is stretched. On mimicking this process with a combination of enzymes buried in polyelectrolyte layers on a silicone sheet, it is shown that enzymatic catalysis is possible only when the substrate is stretched to expose the enzymes, which enables reversible control of reaction progression.
- Damien Mertz
- Cédric Vogt
- Philippe Lavalle
