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Showing 1–4 of 4 results
Advanced filters: Author: Jessica Tantivit Clear advanced filters

  • Microscopic colitis is a chronic inflammatory disease of the large intestine. Here the authors use single-cell RNA transcriptomic profiling and tissue localization studies to characterise the colon immune cell populations in MC, showing expansion of CD8 T cells with diverse TCR clonotypes and expression of CD4 T reg cell signatures.

    • Stefan Halvorsen
    • Molly Thomas
    • Hamed Khalili
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Single-cell multi-omic analysis of 300,000 cells from 29 patients representing peripheral immune cells and colon mucosal immune, epithelial and mesenchymal cells reveals crosstalk between circulating and tissue-resident immune cells with epithelial cells in checkpoint inhibitor colitis and identifies potential therapeutic targets.

    • Molly Fisher Thomas
    • Kamil Slowikowski
    • Alexandra-Chloé Villani
    Research
    Nature Medicine
    Volume: 30, P: 1349-1362

  • An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang
    Research
    Nature Medicine
    Volume: 27, P: 546-559