Nature Search

Enantioselective formal (3 + 3) cycloaddition of bicyclobutanes with nitrones enabled by asymmetric Lewis acid catalysis

The absence of catalytic asymmetric methods for synthesizing chiral (hetero)bicyclo[n.1.1]alkanes has hindered their application in new drug discovery. Herein the authors report an enantioselective formal (3 + 3) cycloaddition of bicyclobutanes with nitrones using a chiral Lewis acid catalyst for the synthesis of hetero-bicyclo[3.1.1]heptane.

Wen-Biao Wu
Bing Xu
Jian-Jun Feng
ResearchOpen Access13 Sept 2024
Nature Communications

Volume: 15, P: 1-9
Bioactivity, pharmacokinetics, and immunogenicity assays in preclinical and clinical trials for recombinant human endostatin

Bi Hu
Hao-wen Zhu
Gen-xing Xu
Research01 Nov 2008
Acta Pharmacologica Sinica

Volume: 29, P: 1357-1369
Central-peripheral neuroimmune dynamics in psychological stress and depression: insights from current research

Xiao Feng
Min Jia
Kenji Hashimoto
ReviewsOpen Access03 Jul 2025
Molecular Psychiatry

P: 1-18
Corrigendum: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54

Li-Dong Wang
Fu-You Zhou
Xue-Jun Zhang
Amendments and Corrections01 Sept 2014
Nature Genetics

Volume: 46, P: 1041
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21

Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibility, and report a new association within the LCE gene cluster at 1q21.

Xue-Jun Zhang
Wei Huang
Jian-Jun Liu
Research25 Jan 2009
Nature Genetics

Volume: 41, P: 205-210
Reservoir computing-based signal compensation for laser inter-satellite communications

Feng Wen
Juan Yong
Shui-Qiu Diao
ResearchOpen Access15 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Low dose of moxonidine within the rostral ventrolateral medulla improves the baroreflex sensitivity control of sympathetic activity in hypertensive rat

Jia-ling Wang
Long Wang
Wei-zhong Wang
Research04 Dec 2009
Acta Pharmacologica Sinica

Volume: 30, P: 1594-1600
The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients

Rui-Li Zhang
Xu Zhang
Qian-Qiu Wang
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-8
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

Xuejun Zhang and colleagues report results of a genome-wide association study of systemic lupus erythematosus (SLE) in a Chinese Han population. Their work identifies nine new SLE susceptibility loci and reveals overlap in the spectrum of risk alleles shared between Chinese Han and European populations.

Jian-Wen Han
Hou-Feng Zheng
Xue-Jun Zhang
Research18 Oct 2009
Nature Genetics

Volume: 41, P: 1234-1237
Dual-comb spectroscopy over a 100 km open-air path

Dual-comb spectroscopy with time–frequency dissemination and high-power frequency combs enables sensing CO₂ and H₂O over a 113 km turbulent open-air path, with a sensing precision as high as 2 parts per million of CO₂.

Jin-Jian Han
Wei Zhong
Jian-Wei Pan
Research12 Sept 2024
Nature Photonics

Volume: 18, P: 1195-1202
KKK879-881 motif is an ER-retention signal in GluN2A-NMDA receptor

Qing-Qing Li
Jiang Chen
Yun Stone Shi
Research29 Nov 2022
Molecular Psychiatry

Volume: 27, P: 3115
Ultra-high dose rate radiotherapy overcomes radioresistance in head and neck squamous cell carcinoma

Hong-Shuai Li
Ruo Tang
Xing-Chen Peng
ResearchOpen Access03 Mar 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-17
Satellite-to-ground quantum key distribution

Decoy-state quantum key distribution from a satellite to a ground station is achieved with much greater efficiency than is possible over the same distance using optical fibres.

Sheng-Kai Liao
Wen-Qi Cai
Jian-Wei Pan
Research09 Aug 2017
Nature

Volume: 549, P: 43-47
Selective detection of viable seed-borne Acidovorax citrulli by real-time PCR with propidium monoazide

Qian Tian
Jian-jun Feng
Wen-jun Zhao
ResearchOpen Access14 Oct 2016
Scientific Reports

Volume: 6, P: 1-8
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1

Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.

Li-Dong Wang
Fu-You Zhou
Xue-Jun Zhang
Research22 Aug 2010
Nature Genetics

Volume: 42, P: 759-763
Free-space dissemination of time and frequency with 10⁻¹⁹ instability over 113 km

By using 1 W optical frequency combs and nanowatt-level linear optical sampling modules, a time–frequency dissemination over a free-space link of 113 km is achieved with a stability of less than 4 × 10⁻¹⁹ at 10,000 s.

Qi Shen
Jian-Yu Guan
Jian-Wei Pan
Research05 Oct 2022
Nature

Volume: 610, P: 661-666
Clinical impact of blood pressure on cardiovascular death in patients 80 years and older following acute myocardial infarction: a prospective cohort study

Meng Zhang
Xiao-Ni Yan
Jian-Jun Li
Research20 Sept 2022
Hypertension Research

Volume: 45, P: 1882-1890
Unloading Characteristics of Sand-drift in Wind-shallow Areas along Railway and the Effect of Sand Removal by Force of Wind

Jian-jun Cheng
Guo-Wei Xin
Fu-qiang Jiang
ResearchOpen Access25 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population

Xue-Jun Zhang, Zhi-Rong Yao and colleagues report a genome-wide association study for atopic dermatitis in the Chinese Han population. They identified two new susceptibility loci at 5q22 and 20q13.

Liang-Dan Sun
Feng-Li Xiao
Xue-Jun Zhang
Research12 Jun 2011
Nature Genetics

Volume: 43, P: 690-694
The homozygous LRRK2.p.N1437D point mutation mouse is a novel model of parkinsonism

Lin-Hua Gan
Yi-Min Sun
Jian-Jun Wu
ResearchOpen Access28 Mar 2025
npj Parkinson's Disease

Volume: 11, P: 1-13
In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI

Wei-Yuan Huang
Meng-Meng Li
Jian-Jun Li
ResearchOpen Access26 Oct 2018
Scientific Reports

Volume: 8, P: 1-8
Serological Response Predicts Normalization of Cerebrospinal Fluid Abnormalities at Six Months after Treatment in HIV-Negative Neurosyphilis Patients

Yao Xiao
Man-Li Tong
Jian-Jun Niu
ResearchOpen Access30 Aug 2017
Scientific Reports

Volume: 7, P: 1-7
Integrated Prototype Nanodevices via SnO₂ Nanoparticles Decorated SnSe Nanosheets

Jian-Jun Wang
Ai-Feng Lv
Li-Jun Wan
ResearchOpen Access10 Sept 2013
Scientific Reports

Volume: 3, P: 1-6
Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis

Xue-Jun Zhang, Jun Wang and colleagues identify mutations in MVK in disseminated superficial actinic porokeratosis, a disorder characterized by defects in epidermal keratinization. MVK encodes mevalonate kinase, an enzyme involved in the biosynthesis of cholesterol and isoprenoids.

Sheng-Quan Zhang
Tao Jiang
Xue-Jun Zhang
Research16 Sept 2012
Nature Genetics

Volume: 44, P: 1156-1160
Hierarchically Structured Silica from Mediation of Linear Poly(ethyleneimine) Incorporated with Acidic/Basic Additives

Ren-Hua Jin
Jian-Jun Yuan
Reviews09 Apr 2007
Polymer Journal

Volume: 39, P: 464-470
Association analyses identify six new psoriasis susceptibility loci in the Chinese population

Xue-Jun Zhang and colleagues report genome-wide association analyses identifying six new susceptibility loci in the Chinese population.

Liang-Dan Sun
Hui Cheng
Xue-Jun Zhang
Research17 Oct 2010
Nature Genetics

Volume: 42, P: 1005-1009
Factors affecting in-stent restenosis after angioplasty with the Enterprise stent for intracranial atherosclerotic diseases

Kun Zhang
Tian-Xiao Li
Jin-Chao Xia
ResearchOpen Access18 May 2021
Scientific Reports

Volume: 11, P: 1-11
Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

Hai-Dong Zhu
Hai-Liang Li
Gao-Jun Teng
ResearchOpen Access08 Feb 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-10
Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory

Qing-Qing Li
Jiang Chen
Yun Stone Shi
Research28 Apr 2022
Molecular Psychiatry

Volume: 27, P: 3468-3478
Bifidobacterium adolescentis as a delivery system of endostatin for cancer gene therapy: Selective inhibitor of angiogenesis and hypoxic tumor growth

Xi Li
Geng-Feng Fu
Gen-Xing Xu
Research21 Jan 2003
Cancer Gene Therapy

Volume: 10, P: 105-111
Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Sanjay Jain
Liming Pei
Michael P. Snyder
Amendments and Corrections01 Mar 2024
Nature Cell Biology

Volume: 26, P: 839
The genetic spectrum of a cohort of patients clinically diagnosed as Parkinson’s disease in mainland China

Yi-Min Sun
Xin-Yue Zhou
Jian Wang
ResearchOpen Access17 May 2023
npj Parkinson's Disease

Volume: 9, P: 1-9
The prevalence of masked hypertension and masked uncontrolled hypertension in relation to overweight and obesity in a nationwide registry in China

Our study showed that overweight and obesity were associated with a higher prevalence of masked uncontrolled hypertension but not masked hypertension, indicating that clinic blood pressure might overestimate antihypertensive treatment effects in patients with overweight and obesity.

Jia-Hui Xia
Dong-Yan Zhang
Ji-Guang Wang
Research14 Sept 2022
Hypertension Research

Volume: 45, P: 1690-1700
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

Sanjay Jain
Liming Pei
Michael P. Snyder
Reviews19 Jul 2023
Nature Cell Biology

Volume: 25, P: 1089-1100
Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis

Jian-Jun Guo
Feng Yue
Jia-Yi Li
ResearchOpen Access13 Jan 2021
Cell Death & Disease

Volume: 12, P: 1-14
Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics study

Jun-Xi Pan
Jin-Jun Xia
Peng Xie
ResearchOpen Access10 Jul 2018
Translational Psychiatry

Volume: 8, P: 1-10
RETRACTED ARTICLE: Three SAUR proteins SAUR76, SAUR77 and SAUR78 promote plant growth in Arabidopsis

Zhi-Gang Li
Hao-Wei Chen
Jin-Song Zhang
ResearchOpen Access24 Jul 2015
Scientific Reports

Volume: 5, P: 1-19
China’s first step towards probing the expanding universe and the nature of gravity using a space borne gravitational wave antenna

Gravitational wave astronomy has opened the door to test general relativity and the effect of gravity in the Universe. The authors present the capabilities of an overlap between space gravitational wave detectors LISA and Taiji to constrain the Hubble constant to 0.5%, in 10 years, and what can be learned from the satellite pilot Taiji-1 launched in 2019.

Yue-Liang Wu
Zi-Ren Luo
Zi-Ming Zou
ReviewsOpen Access24 Feb 2021
Communications Physics

Volume: 4, P: 1-7

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