Search

Phosphorus is vital for permafrost ecosystems. Here, the authors combine soil resampling with a modified process-balanced model to assess the historical changes of soil phosphorus and the key flows of phosphorus across the Tibetan permafrost region.

This study utilizes Stereo-seq to comprehensively map the geospatial architecture of breast cancer, revealing venular niches that promote immune infiltration and better clinical outcomes, offering new insights into tumor microenvironment regulation.

Catalytic and enantioselective construction of chiral α,α-dialkyl indoles represents an important yet challenging objective to be developed. Herein the authors describe a cobalt catalyzed enantioselective anti-Markovnikov alkene hydroalkylation via the remote stereocontrol for the synthesis of α,α-dialkyl indoles and other N-heterocycles.

Two small-molecule modulators (Ebio2 and Ebio3) of the potassium channel KCNQ2 were developed using the same chemical scaffold. The modulators show opposite effects: Ebio2 acts as an activator, whereas Ebio3 serves as a selective inhibitor, with the different activity depending on the modulator tail group.

Developing classes of substrates for the Nazarov reaction is an important endeavour for synthetic chemistry. Here, the authors report how enyne diketones undergo rhodium-catalyzed metal-organo relay catalysis for the enantioselective construction of chiral allene cyclopentenones via Nazarov cyclisation in good yields and enantioselectivities.

Acidic electrochemical CO₂ conversion is a promising alternative to overcome low CO₂ utilization. Here, the authors report a robust carbon coated tip-like In₂O₃ electrocatalyst that demonstrates an enhanced activity for the direct production of HCOOH in a strongly acidic and low K⁺ electrolyte.

In C. elegans, systemic RNAi is initiated by SID-1-mediated dsRNA internalization. Here the authors present cryo-EM structures of SID-1 homologs and the SID-1–dsRNA complex, elucidating the structural basis for dsRNA recognition and uptake by SID-1.

Xu et al. report structures of the Arabidopsis cytokinin importer AZG1 in the apo, trans-zeatin-bound, 6-benzyleaminopurine-bound and kinetin-bound states, and elucidate an elevator transport model for the AZG1-mediated cytokinin uptake.

Product-selective switching of CO₂ hydrogenation is a huge challenge. Here, the authors report an approach to manipulating Fe-Co sites with three-dimensional graphene fences that achieves integrated synthesis of different products.

The voltage-gated sodium channel Na_V1.7 plays essential roles in pain sensation. The authors report cryo-EM structures of Na_V1.7 in complexes with three pore blockers, elucidating distinct mechanisms of action of their modulation on Na_V1.7.

Recent studies have reported the exceptional plasticity of InSe van der Waals crystals, but their deformation-correlated lattice dynamics remains unexplored. Here, the authors investigate the correlations of plastic interlayer slip, lattice anharmonicity and thermal transport in β-InSe crystals via neutron scattering techniques.

Voltage-gated sodium channels mediate electrical signaling. Here, authors report the cryo-EM structure of Na_VEh from the marine plant Emiliania huxleyi, revealing an unexpected mechanism of N-type fast inactivation.

Photonic crystals (PhCs) are artificial periodic materials that can be used to manipulate the flow of light. Here, the authors report the realization of asymmetric PhCs based on in-plane hyperbolic phonon polaritons in perforated α-MoO₃, showing low-symmetry deep-subwavelength Bloch modes that are robust against lattice rearrangement in specific directions.

Cascaded compression, in which nanopores are compressed by cycles of shrinkage and expansion, is described, leading tohigh-density nanopores in monolayer graphene with a narrow pore-size distribution, left skewness and ultrasmall tail deviation.

The potassium channel KCNQ2 can be activated by analgesics and antiepileptic drugs via an unclear mechanism. Here authors report structures of KCNQ2-CaM in complex with cannabidiol, PIP2, and HN37 and elucidate the mechanisms of activation.

Cryo-EM structures of the mouse TRPV2 channel, combined with electrophysiology and simulations, reveal that endogenous cholesterol binds to the vanilloid binding pocket to inhibit this channel, while exogenous 2-APB binds to same pocket to open TRPV2.

The addition of DDT to the spiro-OMeTAD hole transport material enhances the stability of perovskite solar cells to humidity, heat and illumination stress. Fabricated devices exhibit a champion certified power conversion efficiency of 23.1%. Also, the devices could retain 90% of the initial efficiency after 1,000 h of continuous illumination, 97% under moisture stress for 530 h and 91% under 144 h of heat stress.

Arabidopsis thaliana PIN3 structures reveal the molecular mechanisms of the transport of indole-3-acetic acid and the inhibition of polar auxin transport by N-1-naphthylphthalamic acid.

Inactivation is an intrinsic property of Na_V channel, but the mechanism for slow inactivation is not fully understood. Here, authors show a Na_VEh structure in a potential slow-inactivated state, elucidating structural basis for slow inactivation.

Identification of a small molecule (Ebio1) reveals a unique activation mechanism for the KCNQ2 potassium channel. Ebio1 induces a twist-to-open movement in the S6 helices, creating an extended channel gate with enhanced conductance.

Proton-linked monocarboxylate transporters (MCTs) facilitate monocarboxylate efflux in glycolytically active cells and regulate transport down in glycolytically inactive cells. Here authors show a steep dependence of human MCT2 activity on substrate concentration and show the structural basis of cooperative transport.

ASB7 acts as the substrate receptor for cullin 5 RING E3 ubiquitin ligase (CRL5), targeting the internal α-helix degron for degradation. Here, the authors elucidate the molecular mechanism of substrate recognition by ASB7 using structural, biochemical and cellular analyses.

The main hurdle to the deployment of carbon nanotubes in the electronics industry is the requirement of obtaining pure semiconductor nanotube horizontal arrays. Here, a method is presented to prepare highly pure semiconductor nanotubes by switching the direction of an applied electric field during synthesis.

Damage-tolerant ceramic aerogels are valuable, yet their synthesis is time-consuming and expensive. Here we report a facile, low-cost combustion synthesis of SiC aerogels, at Liter scale. Further technological development may enable game-changer aerogels for extreme-environment applications.

While light-driven water splitting offers a renewable means to produce fuel, the limited availability of high-performance materials inspires the search for new photocatalysts. Here, authors demonstrate two-dimensional NiPS₃ to enhance semiconductor photocatalytic H₂ evolution activities.

Cyclic peptides are important bioactive compounds and drugs, synthesised by enzymatic side-chain macrocyclization of ribosomal peptides, which rarely involves histidine residues. Here, the authors report the discovery and biosynthesis of tricyclic lanthipeptide noursin, constrained by a tri amino acid labionin crosslink and histidine-to-butyrine crosslink, which is important for copper binding of noursin.

A non-destructive soft-lock drawing method can achieve carbon nanotube arrays with ultraclean surfaces and a very high degree of alignment. Such arrays could be used as nano-sized electrical contacts of high-density monolayer MoS₂ transistors.

The use of epidermal growth factor for wound healing is limited by transdermal permeability, reduction, and receptor desensitization. Here the authors develop a microneedle-based self-powered transcutaneous electrical stimulation system to overcome these challenges.

Voltage-gated sodium channels function as multiprotein signaling complexes. Here, authors show that the dispanin TMEM233 is essential for activity of stinging nettle toxins and that co-expression of TMEM233 modulates the gating properties of Na_V1.7.

Fabrication of wafer-scale nanogratings for X-ray spectroscopy is difficult especially for very high line densities. The authors use vacancy epitaxy to fabricate sub-50-nm-periodicity gratings, coated with multilayers for efficient operation, for use in ultra-high resolution x-ray spectroscopy.

The dissolution of the solid–electrolyte interphase formed during repeated cycling severely deteriorates the performance of sodium-ion batteries. Here the authors develop an electrolyte that effectively suppresses the dissolution and consequently enables a long-cycle and high-voltage sodium-ion battery.

High-precision printing of flexible wireless electronics has not been achieved before. Here, the authors leverage a room-temperature direct printing strategy to realize an all-MXene-printed integrated system capable of wireless communication, energy harvesting, and smart sensing.

Monolayer MoS₂ is grown at the back end of the line of 200 mm silicon CMOS wafers at a temperature of <300 °C, and hybrid silicon CMOS/MoS₂ circuits are demonstrated through heterogeneous integration.

The mechanism of cold-activated TRPM8 channel activation remains unclear. Here, authors have determined structures of mouse TRPM8 in apo or ligand-bound states, providing insights into the activation of TRPM8 structures in different states.

Zi-Jiang Chen and colleagues report a genome-wide association analysis for polycystic ovary syndrome (PCOS) in Han Chinese. They identify eight new susceptibility loci for PCOS in this population.

Current commercialized production processes of glyphosate are generally associated with manufacturing hazards and toxic wastes. Here, to address the problems, the authors report the bioproduction of aminomethylphosphonate (AMP) and a chemical process for the conversion of AMP to glyphosate.

Engineering thin membranes for molecular separation with well tailored nanoporosity and which can withstand harsh conditions is still a big challenge. Here, the authors introduce a trianglamine macrocycle as a molecular building block for cross-linked membranes, prepared by facile interfacial polymerization, for high performance selective separations.