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Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

MorphLink is a computational framework that links tissue morphology changes to molecular alterations using spatial omics data, providing intuitive visualisations of cellular behaviours from both structural and molecular perspectives.

Distinguishing benign renal masses from malignant renal tumours, and further differentiating indolent from aggressive renal cancers, on computed tomography (CT) scans remains challenging. Here, the authors develop deep learning models for distinguishing benign from malignant renal masses, and differentiating indolent from aggressive renal tumours in a large cohort of preoperative CT scans, obtaining high accuracy and a strong association with clinical outcomes.

Some patients present with multiple lung tumours but it is unclear whether these are metastases or individual lesions. Here, the authors use genomics techniques to demonstrate in six patients that multiple tumours have individual genetic profiles and represent separate tumours.

Serine metabolism is essential for leukemogenesis and stemness in acute myeloid leukemia (AML). Here the authors show that targeting IGF2BP3 disrupts the serine synthesis pathway in AML cells in an RNA N⁶-Methyladenosine modification dependent manner, sensitizing AML cells to serine and glycine deprivation.

Artificial transcription factors (ATFs) are core elements of customized circuits responsible for signal output and event transformation. Here, the authors report the design of a protease-responsive conformationally inhibited system (PRCIS) in responsiveness to multiple proteases and chemical inducers.

Azoxy products have rarely been synthesized using enzyme catalysts. Herein, the authors report that fungal unspecific peroxygenases are promising catalysts for synthesizing azoxy products from simple aniline starting materials.

Plastic photoreforming offers a promising route for recycling plastic waste but typically depends on unsustainable, corrosive conditions. Here, the authors present a floatable organic–inorganic hybrid TiO₂ material that enables efficient conversion of common plastics such as PE, PP, and PVC under neutral conditions.

A high-resolution terrain dataset was developed for the CE-6 landing site, revealing that its exposure age lies between CE-4 and CE-5 sites, with diverse material sources and covered by ejecta from a nearby 51-meter crater.

Conventional methods for nanoparticle cluster formation involve surface functionalization, which can alter the properties. Here, the authors propose a non-disruptive strategy to position nanomaterials of different shapes between nanosheets without the need for pre-modification.

The deficiency of MTAP, an enzyme of the adenine salvage pathway, occurs in some cancers. Here the authors perform a small cohort phase II clinical trial with metastatic MTAP-deficient urothelial cancer (UC) and show an increased overall response when comparing to MTAP-proficient UC patients.

Clinical evidence suggests that debulking surgery in patients with metastatic disease could enhance response to immune checkpoint therapy. Here the authors report the results of a clinical trial of immune checkpoint inhibitors plus debulking surgery in patients with metastatic renal cell carcinoma.

Disorder has emerged as a promising tool to manipulate properties of superconducting circuits. Here the authors demonstrate the use of disordered spinodal superconductor for fluxonium qubit fabrication and reveal an interesting correlation between the material disorder and the 1/f-type flux noise.

In a randomized phase 3 trial, neoadjuvant anti-PD-1 plus either paclitaxel and cisplatin or nab-paclitaxel and cisplatin elicited a significantly superior pathological complete response rate versus neoadjuvant paclitaxel and cisplatin alone in patients with resectable locally advanced esophageal squamous cell carcinoma.

Small-cell lung cancer (SCLC) is an aggressive disease with limited therapeutic options. Here the authors perform an immunogenomic analysis of limited-stage SCLC, revealing a homogeneous mutational landscape, but limited T-cell infiltration and a cold and heterogeneous T cell repertoire.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Magnetoelectric composites of magnetic and ferroelectric components are promising for their use in applications such as information storage. Here, the authors find that magnetic quasiparticles embedded in a ferroelectric film matrix show promising properties compared to the usual thin-film architectures.

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

Copper-mediated SEC14L3 activates the ERK/YY1/FDX1 axis to promote cuproptosis and suppress hepatocellular carcinoma progression.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

In patients with advanced clear cell renal cell carcinoma (ccRCC), sitravatinib (tyrosine kinase inhibitor) has shown efficacy both alone and in combination with nivolumab (anti-PD-1). Here, the authors investigate triplet combination of sitravatinib with nivolumab and ipilimumab (anti-CTLA4) in patients with metastatic ccRCC and longitudinal single-cell transcriptomic analysis.

Superconductivity was recently discovered in La₄Ni₃O₁₀ under pressure in proximity to a density-wave phase. Here, by stabilizing a tetragonal form of La₄Ni₃O₁₀ at ambient pressure, the authors show that the density-wave state is crucial for the superconductivity, but the tetragonal structure is not.

The Chang’E-4 mission in January 2019 had the major challenge to land on the lunar far side without traditional radiometric techniques due to the missing line-of-sight. The authors here describe landing trajectory reconstruction and positioning techniques based upon the Moon’s digital terrain model that allowed reproducing the entire process of a successful landing.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

The molecular determinants of lung cancer histologic subtypes are not well understood. Here the authors analyze lung cancers of mixed histology and find that histologic subtypes are associated with transcriptomic features rather than genomic profiles in most tumors.

Here authors show that EVs derived from hepatocellular carcinomas may contain the long noncoding RNA, HDAC2-AS2, which suppresses antitumour CD8 + T cells by interfering with transcriptional and epigenetic regulation of their activated, cytotoxic functional state.

RNA methylation has recently identified as an important regulatory mechanism governing functional cellular states, but its effect on the antitumour activity of CD8 ⁺ T cells is not fully explored. Here authors assign an essential nuclear, m⁶A-recognition-dependent function to YTHDF2, which, in conjunction with its regulatory role in IKZF1/3-mediated gene transcription, governs anti-tumor activity in CD8 ⁺ T cells.

Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.

New design paradigms are needed to advance the performance of solid polymer electrolytes beyond conventional systems. The role of a helical secondary structure is now shown to greatly enhance the conductivity of solvent-free polymer electrolytes using cationic polypeptides with a mobile anion.

Detection of quantum oscillations in thermal transport could shed light on the origin of thermal Hall effect in correlated materials but it is challenging. Here the authors report quantum oscillations in the thermal Hall effect in the kagome metal CsV₃Sb₅ indicating strong violation of the Wiedemann–Franz law.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.

MISO (MultI-modal Spatial Omics) integrates two or more spatial omics modalities, despite differences in data quality and spatial resolution for improved feature extraction and clustering to reveal biologically meaningful tissue organization.

Predicting recurrence risk in non small cell lung cancer can help to guide treatment decisions. Here, the authors use CT and PET imaging to develop predictive imaging subtypes, which can be integrated with existing ctDNA methods to predict recurrence.