Search

Zhang et al. show that YAP binds to TDP-43 to promote TDP-43 multimerization and phase separation. YAP and TDP-43 may co-localize in multiple cell types in oxidative stress and in brain samples from individuals with amyotrophic lateral sclerosis.

Chang’e-6 farside samples show heavy δ³⁴S values similar to the nearside, supporting global lunar volatile loss induced by the giant impact.

It is generally more difficult to modify the buried interfaces compared to top interfaces in tin-lead perovskite subcells. Here, the authors employ a mercapto-functionalized mesoporous silica layer as a superstructure, realizing maximum efficiency of 29.6% for double-junction tandem solar cells.

The authors present a strategy for controlling magnetic phase transitions in two-dimensional ferroelectrics, showing that electron pairing governs transitions between ferromagnetic and nonmagnetic states, tunable via electric fields.

The topological properties of twisted bilayer MoTe₂ are thought to stem from a spatial texture in the layer polarization of the electronic wavefunctions. This polarization is now measured using scanning tunnelling microscopy.

In analogy with quantum Hall systems, it may be possible to find non-abelian anyons in the higher bands of Chern insulators. Now, the phase diagram of the second moiré band of twisted MoTe₂ is explored, laying the groundwork for such investigations.

The spatial heterogeneity of peritumoral brain zone (PBZ) in glioblastoma, where 90% of reoccurrence occurs, remains poorly characterised. Here, the authors suggest that high cerebral blood flow regions in the PBZ are the main regions of tumour and immune cell infiltration.

Propane dehydrogenation is an important reaction for the production of propylene, although effective catalysts are generally constructed from precious metals. Here, the authors report a high-performing earth-abundant alternative system for this reaction based on a particular form of cobalt on siliceous zeolites.

The spike protein of the Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 than Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic and vaccine-elicited neutralizing antibodies.

Microwell-seq is used to generate single-cell, whole-body expression landscapes of zebrafish, Drosophila and earthworm. A deep-learning model, Nvwa, predicts gene expression from DNA sequence and identifies regulatory programs shared across eight species.

Zheng and colleagues report that targeting both the death ___domain and the paracaspase ___domain of MALT1 with antisense oligonucleotides sensitizes resistant tumors to immune-checkpoint inhibition.

The performance of inorganic, wide-bandgap perovskite solar cells is hindered by unsuitable electron transport layers. Han et al. design an acidic magnesium-doped tin oxide quantum dot layer, improving efficiency and stability in single-junction and tandem cells.

An analysis of single-cell RNA sequencing data from adult and developing lungs across vertebrate species reveals genetic components in the common ancestor of jawed vertebrates and new lung-specific enhancers that contribute to the evolution of vertebrate lungs.

A selective shielding strategy achieves the differentiation and quantification of distinct plasmonic photocatalytic mechanisms including hot carrier-driven photochemistry, resonant field-mediated energy transfers, and thermal contributions.

Oxidative carbonylation using CO/O₂ is an attractive strategy to construct carbonyl compounds, but the explosive limit of the gas mixture hampers its application. Now, this safety issue is overcome in the aminocarbonylation of alkynes by replacing the external oxidant O₂ by electrochemistry facilitating a mild and safe reaction.

This study reveals how the North Atlantic Oscillation emerged and evolved over 160 million years, highlighting the role of continental drift, land-ocean contrast, and orography in shaping modern atmospheric variability.

Predictive electrocatalyst design is challenged by uncontrollable precatalyst reconstruction during operation. Here, informed by operando spectroscopies, activation protocols are developed to stabilize surfaces and improve catalyst reliability.

Transplanted older livers are prone to injury through unclear mechanisms, precluding effective treatment development. Here, the authors show that decreased FTO expression in older livers inhibits Acsl4 and Tfrc mRNA stability in an m6A-dependent manner, increasing cell death in older donor livers.

Clean air actions affect air quality greatly. Here, the authors report widespread decreases in organic aerosol (OA) in China from 2013 to 2020 with primary OA decreasing more than secondary OA. However, further reductions are challenging.

The functional role of the co-presence of aberrant long non-coding RNAs (lncRNAs) and coding genes in cancer remains poorly understood. Here, the transcriptional regulator Prohibitin 2 (PHB2) is shown to co-regulate the transcription of an oncogenic CASC15- New-Isoform 2 (CANT2) lncRNA and the tumour-suppressor gene CCBE1 accelerating tumorigenesis of melanoma.

The pilot phase of PigGTEx, re-analyzing 5,457 published RNA-seq samples, presents a pan-tissue catalog of molecular quantitative trait loci. Cross-species comparisons identify traits with shared genetic regulation in humans.

Low formation efficiency of monkey blastoid cavities, typically below 30%, has limited their utility. Here, the authors achieve 80% efficiency from aged/young monkey stem cells and develop a hydrogel microfluidics platform for scalable production

Formic acid (FA) is a promising CO2-equivalent feedstock for onecarbon biorefinery, but microbial host that can efficiently utilize FA is unavailable. Here, the authors engineer a non-native closed loop in Vibrio natriegens and demonstrate its application in promoting FA utilization.

Wang and colleagues revealed how oleic acid produced by thymic epithelial cells could affect the developing thymocytes to differentiate into peripheral regulatory T cells.

The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.

Materials popular for insulation and noise reduction are typically derived from petroleum or minerals or have other environmental costs. This study reports a scalable material for thermal insulation and noise reduction derived from treated wood.

The P681R mutation in the spike protein renders the Delta variant more pathogenic than prototypic SARS-CoV-2 in infected hamsters, and facilitates spike protein cleavage and enhances viral fusogenicity.

Genome and transcriptome analyses of 376 Gossypium hirsutum accessions uncover the regulation of gene expression during fiber development in allotetraploid cotton and highlight the potential for fiber quality improvement.

Through development of non-fullerene acceptors, OPVs have reached efficiencies of 18%, yet the inadequate operational lifetime still poses a challenge for the commercialisation. Here, the authors investigate the origin of instability of NFA solar cells, and propose some strategies to mitigate this issue.

XBB is the first recombinant, globally dominant variant of SARS-CoV-2. Here, the authors examine the variant’s origins and virological properties, showing it is the first example of SARS-CoV-2 improving its fitness through recombination.

Male breast cancer may involve different populations of immune cells. Here the authors use single cell transcriptomics to show that infiltration of T cells is lower in male breast cancer relative to female breast cancer, and find that this is accompanied by distinct metabolic changes.

SRDTrans is a self-supervised denoising method for fluorescence images powered by spatial redundancy sampling and a dedicated transformer network that achieves good performance on fast dynamics and various imaging modalities.

Orthogonally conjugating the cytokine interleukin-2 to poly(ethylene glycol) moieties at defined protein sites improves its pharmacokinetics and half-life as well as its therapeutic performance in mouse models of autoimmune diseases.

Protein kinase-mediated phosphorylation plays a critical role in many biological processes. Here the authors develop a trans-omics-based algorithm called Central Kinase Inference to integrate quantitative transcriptomic and phosphoproteomic data, finding that PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest.

Here the authors show disturbing parental histone inheritance in cancer cells drives tumor progression by reprogramming the epigenetic profile and conferring fitness advantages to some of the newly emerged subclones.

Transport measurements in twisted bilayer MoTe₂ reveal quantized Hall resistance plateaus and composite Fermi liquid-like behaviour under zero magnetic field, constituting a direct observation of integer and fractional quantum anomalous Hall effects.

This study investigates the regulatory mechanisms of DNA-lncRNA triplexes, specifically their role in gastric cancer through the stable formation and precise oncogenic activity of the SENP5/GAU1 triplex. It shows how PPIA orchestrates the SENP5/GAU1 DNA-lncRNA triplex.

Capturing the detailed structural evolution of electronic excited states is a challenging but critical step to understand and control ultrafast molecular dynamics. Here, combining a Coulomb explosion imaging approach and molecular dynamics simulations, the authors retrieve the transient geometry of the ground and excited states of D2O mono- and dication with few femtosecond, few picometre accuracy.

A cohort study of over 15,000 US adults found that the lifetime risk of developing dementia from ages 55 to 95 is 42%, with the highest risk in APOE ε4 carriers, women and Black adults, and projected that approximately 1 million US adults will develop dementia annually by 2060.

Enrichments from bioreactors find a single bacterium capable of methane oxidation coupled to nitrate reduction via nitrite to dinitrogen, a process previously thought to rely on syntrophy.

Physiologically, the host suppresses intestinal epithelial cell death to prevent intestinal inflammation. Here, the authors show that EF-hand ___domain-containing protein D2 (EFHD2) endogenously suppresses intestinal epithelial cell death by blocking TNFR1 internalization and protects the intestine from excessive inflammation.

Retaining high performance of perovskite solar cells over large areas is a challenge. Yang et al. use a thermotropic liquid crystal with high diffusivity that does not co-crystallize with the perovskite, suppressing defect formation and enabling large-area solar modules with improved stability and efficiency.