Patient-derived glioma cell (PDGC) cultures have been poorly characterized on a molecular level. Here, the authors analyze 50 PDGC lines from glioblastoma patients using multi-omics and drug screening; find molecular subtypes that are associated with drug response and prognosis, as well as a MYC/MYCN-amplification associated with serum-free culture.
- Min Wu
- Tingting Wang
- Jian Chen
