Hyaluronan (HA) is known to inhibit osteoblast differentiation, but its importance in vascular calcification needed clarification. In this study, the authors identify HA as a novel negative regulator of osteogenic differentiation of vascular smooth muscle cells via bone morphogenetic protein 2 signaling. These results indicate that HA may be a novel potential therapeutic agent for the treatment of vascular calcification.
- Yonglun Kong
- Qingchun Liang
- Jianyun Yan
