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A strategy that preserves stereochemistry in intramolecular Friedel–Crafts alkylation is reported. An iterative synthetic approach to extend spiro-bridged molecular skeletons via C–H activation–annulation is developed, where the stereoretentive one-shot conversion to form multiple spirocarbon-bridged carbocycles resembles a ‘zipping up’ process.

Lu and colleagues show that signaling through the lactate receptor HCAR1 in colorectal tumor cells promotes the recruitment of immunosuppressive CCR2⁺ PMN-MDSCs and that inhibition of HCAR1 by reserpine augments the CD8⁺ T cell-mediated antitumor immune response.

Zhong et al. show that, in response to chimeric antigen receptor (CAR) T cell targeting, solid tumors increase the secretion of small extracellular vesicles carrying tumor antigens that are transferred to CAR T cells, resulting in fratricide and reduced antitumor activity.

Visual adaptive devices show promise for simplifying circuits and algorithms in machine vision systems. Here, the authors report a visual adaptive transistor with tunable avalanche effects and microsecond-level bionic vision capabilities, recognizing images in dim and bright conditions with over 98% accuracy.

Macrophage is located in different tissue to serve diverse functions. Here the authors use mass spectrometry and bulk RNA-sequencing to profile 11 mouse macrophage populations from 8 tissues, and combine their de novo data with public datasets to report an integrated proteomic and transcriptomic landscape of mouse macrophage as a valuable resource.

This study of Chinese endometrioid endometrial carcinomas describes the proteogenomic differences between early-onset and late-onset tumors, finding that SIGLEC10 mutation may contribute to tumorigenesis and progestin resistance in early cases.

Neutral sphingomyelinases play pivotal roles in ceramide-related signaling transduction. Here, the authors solve the structure of human neutral sphingomyelinase SMPD2 and propose a catalytic mechanism, potentially enhancing understanding of ceramide in disease and cancer treatment.

Ferroptosis is lipid peroxidation-dependent cell death that has potential to be harnessed as a cancer therapeutic. Here, the authors show that the translation initiation factor eIF4E can repress ALDH1B1 independent of translation, increasing lipid peroxidation levels to promote ferroptosis.

An atlas of candidate cis-regulatory DNA elements (cCREs) in the adult mouse brain unravels the transcriptional regulatory programs that drive the heterogeneity and complexity of brain structure and function.

Understanding the flow of heat in materials just one or a few atoms thick is vital for harnessing them in compact electronic devices. Here, the authors present the temperature-dependent thermal conductivity of black phosphorus ribbons and demonstrate an intrinsic orientation dependence.

Towards intelligent treatment for glaucoma, here authors demonstrate integrated wireless theranostic contact lenses for in situ electrical sensing of intraocular pressure and on demand anti-glaucoma drug delivery.

Bioinks used in current in-situ bioprinting have limitations when applied to complex operational environments. Here, the authors report on the creation of a microgel reinforced GelMA bioink which can be simply prepared and used in different biomedical settings. The application is demonstrated in a cranial defect model.

The impacts of air pollution on mental health have been previously documented but rarely using nationwide large-scale data. This study investigates the short-term and long-term impacts of air pollution on urbanites’ mental health by leveraging national real-time internet search data in China.

The processing of high-performance organic solar cells usually requires environmentally hazardous solvents. Now, hydrocarbon-based processing is shown to achieve relatively high performance in a more environmentally friendly way.

Nasopharyngeal carcinoma (NPC) is a malignant cancer type with high morbidity in Asia, and its current molecular classification is insufficient to predict therapy outcomes. Here the authors explore NPC subtype-specific response to therapy with a pharmacogenomics strategy integrating genomics and drug response of patient-derived organoids.

Squamous cell carcinomas are an aggressive cancer type which can occur in multiple organ systems. Here, the authors analyse the proteome of SCC cancers from 17 organs and show commonly dysregulated proteins independent of ___location.

In organic photovoltaics, electron acceptors are developed to replace fullerenes, and new donors need to be designed to match these acceptors. Here, the authors show that a polymer with strong temperature dependent aggregation and intentionally reduced crystallinity matches non-fullerene acceptors.

Multi-omics profiling of matched normal colon, primary tumor, and liver metastasis from colorectal carcinoma patients based on Hi-C, ATAC-seq and RNA-seq technologies sheds light on the changes and regulatory mechanisms of 3D genomics during the tumorigenesis and metastasis of colorectal carcinoma.

Though high performance electrical interconnects are required for micro/nano electronics, existing metallic nanowires lack structural and electrical stability. Here, the authors report soft manganese-based silicide nanowires with high electrical and structural performance in harsh environments.

The efficiency of organic solar cells depends on the timescale of charge separation, with fast separation achieved through large driving forces. Liu et al. show that non-fullerene organic blends exhibit fast charge separation and efficiency of 9.5% even in the presence of only small driving forces.

The mechanisms underlying pre-metastatic niche formation by cancer derived exosomes is unclear. Here they show that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis, and suggest miR-25-3p as a biomarker for CRC metastasis.

Cellular membranes have distinct lipid compositions despite intermixing, and it is unclear why plasma membrane lipids do not accumulate on endosomes. Here, the authors use the C. elegans embryo to identify lipid transfer proteins and phosphatases that are critical for endosomal lipid homeostasis.

The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.