Nature Search

Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity

Here, the authors show that GalNAc-T3 and T7 regulate furin cleavage of the SARS-CoV-2 spike protein via O-glycosylation. This influences viral assembly and infection, highlighting glycosylation as a host defense mechanism.

Shengjun Wang
Wei Ran
Yang Mao
ResearchOpen Access16 May 2024
Nature Communications

Volume: 15, P: 1-17
Altered microbiota of the lower respiratory tract and its association with COVID-19 severity analysed by metagenomics and metatranscriptomics

Mechanistic modeling of enhancer-RNA sheds light on the role of transcription factors and their interactions in the context of estrogen-induced transcriptional program in breast cancer.

Denian Wang
Yishang Duan
Weimin Li
ResearchOpen Access26 May 2025
Communications Biology

Volume: 8, P: 1-12
A wearable echomyography system based on a single transducer

An echomyography system based on a single transducer can be integrated into a wearable patch and used to monitor breathing patterns and hand gestures.

Xiaoxiang Gao
Xiangjun Chen
Sheng Xu
Research31 Oct 2024
Nature Electronics

Volume: 7, P: 1035-1046
Trim47 prevents hematopoietic stem cell exhaustion during stress by regulating MAVS-mediated innate immune pathway

During periods of stress, it is required to maintain the haematopoietic stem cell (HSC) pool. Here the authors show that Trim47 is important in the survival and function of HSCs after exposure to stress, and prevents haematopoietic failure by inhibiting MAVS-mediated excessive activation of the innate immune pathway.

Fang Chen
Yukai Lu
Junping Wang
ResearchOpen Access08 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Tipping points of marine phytoplankton to multiple environmental stressors

The authors establish machine learning models to identify multifactor tipping points of global marine phytoplankton. They show that temperature and carbon dioxide dominate risks, and project crossing tipping points in tropical area production (50%) and resistance (41%) by 2100 under high emissions.

Zhan Ban
Xiangang Hu
Jinghong Li
Research10 Oct 2022
Nature Climate Change

Volume: 12, P: 1045-1051
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution

A paper-based assay leveraging nucleic acid strand-displacement reactions and the enzymatic amplification of the recognition of viral RNA at the single-nucleotide level allows for the rapid colorimetric detection of SARS-CoV-2 variants.

Ting Zhang
Ruijie Deng
Jinghong Li
Research14 Jul 2022
Nature Biomedical Engineering

Volume: 6, P: 957-967
Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment

Atomically dispersed gold supported by carbon dots amplifies mitochondrial oxidative stress, and leads to irreversible cell damage, inhibiting hepatocellular carcinoma in animal models.

Ningqiang Gong
Xiaowei Ma
Xing-Jie Liang
Research18 Feb 2019
Nature Nanotechnology

Volume: 14, P: 379-387
Proton-driven transformable nanovaccine for cancer immunotherapy

A shape-changing pH-responsive cancer vaccine delivers antigenic peptides directly to the cytoplasm and boosts the cellular immune response upon activation of the inflammasome pathway, efficiently inhibiting tumour growth and extending survival in animal tumour models.

Ningqiang Gong
Yuxuan Zhang
Xing-Jie Liang
Research26 Oct 2020
Nature Nanotechnology

Volume: 15, P: 1053-1064
EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation

Yingnan Bai
Liming Chen
Junbo Ge
ResearchOpen Access18 Nov 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-15
Ultrasound prediction of abnormal infant development in hypertensive pregnant women in the second and third trimester

Guofang Shen
Yajuan Huang
Bing Hu
ResearchOpen Access16 Jan 2017
Scientific Reports

Volume: 7, P: 1-8
The RIFLE versus AKIN classification for incidence and mortality of acute kidney injury in critical ill patients: A meta-analysis

Jiachuan Xiong
Xi Tang
Jinghong Zhao
ResearchOpen Access07 Dec 2015
Scientific Reports

Volume: 5, P: 1-9
31-year contrasting agricultural managements affect the distribution of organic carbon in aggregate-sized fractions of a Mollisol

Ming Sheng
Xiaozeng Han
Na Li
ResearchOpen Access03 Jun 2020
Scientific Reports

Volume: 10, P: 1-10
The chromosome-level Hemerocallis citrina Borani genome provides new insights into the rutin biosynthesis and the lack of colchicine

Zhixing Qing
Jinghong Liu
Jianguo Zeng
ResearchOpen Access07 Apr 2021
Horticulture Research

Volume: 8, P: 1-10
Genome-wide association study using whole-genome sequencing identifies risk loci for Parkinson’s disease in Chinese population

Hongxu Pan
Zhenhua Liu
Beisha Tang
ResearchOpen Access09 Feb 2023
npj Parkinson's Disease

Volume: 9, P: 1-11
Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia

Yang Zheng
Cenglin Xu
Zhong Chen
ResearchOpen Access17 May 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-12
In situ simultaneous monitoring of ATP and GTP using a graphene oxide nanosheet–based sensing platform in living cells

This approach uses fluorescently labeled aptamers and graphene oxide nanosheets to adsorb the aptamers and quench fluorescence. Ligand (e.g., ATP or GTP) binding results in the release of aptamers into solution and fluorescence is "turned on".

Ying Wang
Longhua Tang
Jinghong Li
Protocols24 Jul 2014
Nature Protocols

Volume: 9, P: 1944-1955
PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

Rui Liu
Youwen Chen
Yuanyan Liu
ReviewsOpen Access24 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-12

Search

Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity

Altered microbiota of the lower respiratory tract and its association with COVID-19 severity analysed by metagenomics and metatranscriptomics

A wearable echomyography system based on a single transducer

Trim47 prevents hematopoietic stem cell exhaustion during stress by regulating MAVS-mediated innate immune pathway

Tipping points of marine phytoplankton to multiple environmental stressors

A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution

Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment

Proton-driven transformable nanovaccine for cancer immunotherapy

EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation

Ultrasound prediction of abnormal infant development in hypertensive pregnant women in the second and third trimester

The RIFLE versus AKIN classification for incidence and mortality of acute kidney injury in critical ill patients: A meta-analysis

31-year contrasting agricultural managements affect the distribution of organic carbon in aggregate-sized fractions of a Mollisol

The chromosome-level Hemerocallis citrina Borani genome provides new insights into the rutin biosynthesis and the lack of colchicine

Genome-wide association study using whole-genome sequencing identifies risk loci for Parkinson’s disease in Chinese population

Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia

In situ simultaneous monitoring of ATP and GTP using a graphene oxide nanosheet–based sensing platform in living cells

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

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