Nature Search

A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial

Preliminary results from a phase 2a trial involving 71 patients suggest that a new agent, discovered and designed with artificial intelligence assistance, is safe and effective for the treatment of idiopathic pulmonary fibrosis.

Zuojun Xu
Feng Ren
Alex Zhavoronkov
ResearchOpen Access03 Jun 2025
Nature Medicine

P: 1-9
Sieving pore design enables stable and fast alloying chemistry of silicon negative electrodes in Li-ion batteries

Silicon electrodes promise high energy for lithium-ion batteries but face swelling and durability issues. Here, the authors develop a sieving-pore design that enables stable, fast-charging silicon electrodes with long cycle life, low expansion, and industrial-scale potential.

Jiaxing He
Youzhi Deng
Quan-Hong Yang
ResearchOpen Access25 May 2025
Nature Communications

Volume: 16, P: 1-13
A low-temperature method to produce highly reduced graphene oxide

The chemical reduction of graphene oxide can provide large quantities of reduced graphene oxide for potential application in electronics and composite materials. Feng et al. report a highly efficient low-temperature one-pot reduction of graphene oxide that uses sodium-ammonia solution as the reducing agent.

Hongbin Feng
Rui Cheng
Jinghong Li
Research26 Feb 2013
Nature Communications

Volume: 4, P: 1-8
Conflict between conservation and development: cash forest encroachment in Asian elephant distributions

Peng Liu
Hui Wen
Li Zhang
ResearchOpen Access03 Aug 2017
Scientific Reports

Volume: 7, P: 1-10
Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity

Here, the authors show that GalNAc-T3 and T7 regulate furin cleavage of the SARS-CoV-2 spike protein via O-glycosylation. This influences viral assembly and infection, highlighting glycosylation as a host defense mechanism.

Shengjun Wang
Wei Ran
Yang Mao
ResearchOpen Access16 May 2024
Nature Communications

Volume: 15, P: 1-17
Correction: Corrigendum: A low-temperature method to produce highly reduced graphene oxide

Hongbin Feng
Rui Cheng
Jinghong Li
Amendments and Corrections08 Jul 2013
Nature Communications

Volume: 4, P: 1
Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery

Cancer cell-derived small extracellular vesicles bind to therapeutic nanoparticles leading them from tumours to the liver for degradation. This mechanism is another barrier for the development of efficient nanoparticle-based cancer therapies.

Ningqiang Gong
Wenqun Zhong
Michael J. Mitchell
Research02 Sept 2024
Nature Materials

Volume: 23, P: 1736-1747
Trim47 prevents hematopoietic stem cell exhaustion during stress by regulating MAVS-mediated innate immune pathway

During periods of stress, it is required to maintain the haematopoietic stem cell (HSC) pool. Here the authors show that Trim47 is important in the survival and function of HSCs after exposure to stress, and prevents haematopoietic failure by inhibiting MAVS-mediated excessive activation of the innate immune pathway.

Fang Chen
Yukai Lu
Junping Wang
ResearchOpen Access08 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration

The coordination of pro- and anti-regenerative factors is essential for organ regeneration. The authors show here that proenkephalin-A, secreted by proximal renal tubules in zebrafish, negatively regulates hydrogen peroxide production remodelling H3K4me3 in renal progenitor cells and controlling kidney regeneration strength.

Chi Liu
Xiaoliang Liu
Jinghong Zhao
ResearchOpen Access07 Nov 2023
Nature Communications

Volume: 14, P: 1-15
New loci and coding variants confer risk for age-related macular degeneration in East Asians

Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Here, the authors carry out a two-stage genome-wide association study for AMD and identify three new AMD risk loci, highlighting the shared and distinct genetic basis of the disease in East Asians and Europeans.

Ching-Yu Cheng
Kenji Yamashiro
Chiea Chuen Khor
ResearchOpen Access28 Jan 2015
Nature Communications

Volume: 6, P: 1-10
Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage

How tissues adapt to extreme cold is not well understood. Here, the authors discover a mechanism that promotes FOXO1-mediated cold survival gene transcription at low temperatures, with potential implications for long-term tissue storage for transplantation.

Xiaomei Zhang
Lihao Ge
Jingxing Ou
ResearchOpen Access03 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Correction: Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians

Ching-Yu Cheng
Kenji Yamashiro
Chiea Chuen Khor
Amendments and Corrections30 Mar 2015
Nature Communications

Volume: 6, P: 1
IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4

The pathogenic mechanisms of cardiorenal syndrome type 4 (CRS4) remain unclear. Here, the authors identify IRF1-PGC1α axis-mediated myocardial energy metabolism remodeling as a contributor to CRS4 pathogenesis, thus providing potential new targets for reducing cardiovascular events in CKD patients.

Yinghui Huang
Shaobo Wang
Jinghong Zhao
ResearchOpen Access16 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Molecular Characterization and Viral Origin of the 2015 Dengue Outbreak in Xishuangbanna, Yunnan, China

Yujiao Zhao
Lihua Li
Qiangming Sun
ResearchOpen Access29 Sept 2016
Scientific Reports

Volume: 6, P: 1-8
Correction: Corrigendum: A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Tin Aung
Mineo Ozaki
Chiea-Chuen Khor
Amendments and Corrections27 May 2015
Nature Genetics

Volume: 47, P: 689
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

Tin Aung
Mineo Ozaki
Chiea Chuen Khor
Research29 May 2017
Nature Genetics

Volume: 49, P: 993-1004
Long non-coding RNA AC133552.2: biomarker and therapeutic target in osteosarcoma via PANoptosis gene screening

Wenrui Zhao
Yameng Wang
Jingyu Jia
ResearchOpen Access17 Mar 2025
Scientific Reports

Volume: 15, P: 1-16
The RIFLE versus AKIN classification for incidence and mortality of acute kidney injury in critical ill patients: A meta-analysis

Jiachuan Xiong
Xi Tang
Jinghong Zhao
ResearchOpen Access07 Dec 2015
Scientific Reports

Volume: 5, P: 1-9
A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Tin Aung, Chiea-Chuen Khor and colleagues report the results of a genome-wide association study of exfoliation syndrome. They replicate a known association at LOXL1 and identify a previously unreported association at CACNA1A.

Tin Aung
Mineo Ozaki
Chiea-Chuen Khor
Research23 Feb 2015
Nature Genetics

Volume: 47, P: 387-392
Development and validation of a novel endoplasmic reticulum stress-related lncRNAs signature in osteosarcoma

Peichuan Xu
Jinghong Yuan
Xigao Cheng
ResearchOpen Access26 Oct 2024
Scientific Reports

Volume: 14, P: 1-18
circRNA-ZCCHC14 affects the chondrogenic differentiation ability of peripheral blood-derived mesenchymal stem cells by regulating GREM1 through miR-181a

Daohong Zhao
Hong Chen
Yuhao Zhang
ResearchOpen Access18 Feb 2023
Scientific Reports

Volume: 13, P: 1-12
A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation

Jinghong Li
Willis X. Li
Research19 Nov 2006
Nature Cell Biology

Volume: 8, P: 1407-1414
The inhibitory effect and mechanism of Resina Draconis on the proliferation of MCF-7 breast cancer cells: a network pharmacology-based analysis

Yana Lv
Yan Mou
Guang Li
ResearchOpen Access07 Mar 2023
Scientific Reports

Volume: 13, P: 1-16
The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations

Yangyang Feng
Ming Zhao
Chu-Xia Deng
ResearchOpen Access11 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-13
Allelopathic Polyketides from an Endolichenic Fungus Myxotrichum SP. by Using OSMAC Strategy

Chao Yuan
Yu-Hua Guo
Gang Ding
ResearchOpen Access03 Feb 2016
Scientific Reports

Volume: 6, P: 1-8
Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment

Weinian Liao
Chaonan Liu
Junping Wang
Research30 Aug 2023
Cellular & Molecular Immunology

Volume: 20, P: 1216-1231
Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis

David R. Beers
Weihua Zhao
Stanley H. Appel
ResearchOpen Access17 Sept 2020
Scientific Reports

Volume: 10, P: 1-17
Genome-wide association study using whole-genome sequencing identifies risk loci for Parkinson’s disease in Chinese population

Hongxu Pan
Zhenhua Liu
Beisha Tang
ResearchOpen Access09 Feb 2023
npj Parkinson's Disease

Volume: 9, P: 1-11
Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease

Aaron D. Thome
Farah Atassi
Stanley H. Appel
ResearchOpen Access13 May 2021
npj Parkinson's Disease

Volume: 7, P: 1-12
Reduction Impairs the Antibacterial Activity but Benefits the LPS Neutralization Ability of Human Enteric Defensin 5

Cheng Wang
Mingqiang Shen
Junping Wang
ResearchOpen Access10 Mar 2016
Scientific Reports

Volume: 6, P: 1-12
Association Between Body Mass Index Combined with Albumin: creatinine Ratio and All-cause Mortality in Chinese Population

Jiachuan Xiong
Jinwei Wang
Luxia Zhang
ResearchOpen Access07 Sept 2017
Scientific Reports

Volume: 7, P: 1-7
Bilirubin neurotoxicity is associated with proteasome inhibition

Hongbiao Huang
Mingxing Guo
Jinbao Liu
ResearchOpen Access15 Jun 2017
Cell Death & Disease

Volume: 8, P: e2877
Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation

Xiaoying Lan
Chong Zhao
Jinbao Liu
ResearchOpen Access06 Jul 2017
Cell Death & Disease

Volume: 8, P: e2913

Search

A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial

Sieving pore design enables stable and fast alloying chemistry of silicon negative electrodes in Li-ion batteries

A low-temperature method to produce highly reduced graphene oxide

Conflict between conservation and development: cash forest encroachment in Asian elephant distributions

Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity

Correction: Corrigendum: A low-temperature method to produce highly reduced graphene oxide

Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery

Trim47 prevents hematopoietic stem cell exhaustion during stress by regulating MAVS-mediated innate immune pathway

Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration

New loci and coding variants confer risk for age-related macular degeneration in East Asians

Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage

Correction: Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians

IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4

Molecular Characterization and Viral Origin of the 2015 Dengue Outbreak in Xishuangbanna, Yunnan, China

Correction: Corrigendum: A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Long non-coding RNA AC133552.2: biomarker and therapeutic target in osteosarcoma via PANoptosis gene screening

The RIFLE versus AKIN classification for incidence and mortality of acute kidney injury in critical ill patients: A meta-analysis

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Development and validation of a novel endoplasmic reticulum stress-related lncRNAs signature in osteosarcoma

circRNA-ZCCHC14 affects the chondrogenic differentiation ability of peripheral blood-derived mesenchymal stem cells by regulating GREM1 through miR-181a

A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation

The inhibitory effect and mechanism of Resina Draconis on the proliferation of MCF-7 breast cancer cells: a network pharmacology-based analysis

The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations

Allelopathic Polyketides from an Endolichenic Fungus Myxotrichum SP. by Using OSMAC Strategy

Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment

Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis

Genome-wide association study using whole-genome sequencing identifies risk loci for Parkinson’s disease in Chinese population

Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease

Reduction Impairs the Antibacterial Activity but Benefits the LPS Neutralization Ability of Human Enteric Defensin 5

Association Between Body Mass Index Combined with Albumin: creatinine Ratio and All-cause Mortality in Chinese Population

Bilirubin neurotoxicity is associated with proteasome inhibition

Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation

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