Nature Search

The disparities and development trajectories of nations in achieving the sustainable development goals

Applying economic complexity methods, this study maps global progress toward the SDGs, uncovering distinct development paths and disparities among 166 countries. It highlights overlooked areas in sustainable development, offering insights into how nations can better achieve the SDGs.

Fengmei Ma
Heming Wang
Bojie Fu
ResearchOpen Access28 Jan 2025
Nature Communications

Volume: 16, P: 1-20
Complex structure and activation mechanism of arginine kinase McsB by McsA

Cryo-electron microscopy and biochemical analysis reveal the activation mechanism of protein arginine kinase McsB by its activator McsA for protein quality control under stress in Gram-positive bacteria.

Kai Lu
Bingnan Luo
Zong-Wan Mao
Research04 Sept 2024
Nature Chemical Biology

Volume: 21, P: 402-411
Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation

Injecting Cas9 and gRNA into an animal zygote often produces mosaicism and random biallelic targeting. Here, the authors use pronuclear transfer to reduce mosaicism and selectively target parental alleles.

Yanhe Li
Yuteng Weng
Shaorong Gao
ResearchOpen Access14 Sept 2020
Nature Communications

Volume: 11, P: 1-12
Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1–Drp1 pathway

Shuai Yang
Bin Hu
Jingling Zhao
ResearchOpen Access12 Oct 2020
Cell Death Discovery

Volume: 6, P: 1-11
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries

Genome-wide association analyses across individuals of East Asian and European ancestries identify new risk loci for inflammatory bowel diseases. A polygenic risk score derived from the combined datasets shows improved prediction accuracy.

Zhanju Liu
Ruize Liu
Hailiang Huang
Research08 May 2023
Nature Genetics

Volume: 55, P: 796-806
Severe ocular phenotypes in Rbp4-deficient mice in the C57BL/6 genetic background

Jingling Shen
Dan Shi
Zhenghua Li
Research14 Mar 2016
Laboratory Investigation

Volume: 96, P: 680-691
Knockdown of sodium channel Na_x reduces dermatitis symptoms in rabbit skin

Dermatitis is a chronic inflammatory skin disorder. Na_x is a sodium channel that regulates inflammatory gene expression when the barrier function of the skin is disrupted. Knockdown of Na_x relieves dermatitis symptoms in rabbit dermatitic skin. Na_x is a novel therapeutic target for dermatitis, which currently has limited treatment options.

Jingling Zhao
Shengxian Jia
Seok Jong Hong
Research10 Jan 2020
Laboratory Investigation

Volume: 100, P: 751-761
Rescue of retinal morphology and function in a humanized mouse at the mouse retinol-binding protein locus

Li Liu
Tomohiro Suzuki
Zhenghua Li
Research30 Jan 2017
Laboratory Investigation

Volume: 97, P: 395-408
Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury

Chao Deng
Lin Zhao
Yang Yang
Reviews26 May 2021
Acta Pharmacologica Sinica

Volume: 43, P: 520-528

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The disparities and development trajectories of nations in achieving the sustainable development goals

Complex structure and activation mechanism of arginine kinase McsB by McsA

Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation

Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1–Drp1 pathway

Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries

Severe ocular phenotypes in Rbp4-deficient mice in the C57BL/6 genetic background

Knockdown of sodium channel Na_x reduces dermatitis symptoms in rabbit skin

Rescue of retinal morphology and function in a humanized mouse at the mouse retinol-binding protein locus

Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury

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