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Reprogramming of human urine cells into cardiomyocytes via a small molecule cocktail in xeno-free conditions

Huang et al. chemically reprogram human urine-derived cells into functional cardiomyocyte-like cells under xeno-free conditions using small molecules. The cells exhibit high purity and reprogramming efficiency, and also demonstrate therapeutic promise in both mouse and porcine models of myocardial infarction.

Yu Chen
Aoli Li
Chenwen Huang
ResearchOpen Access01 Jul 2025
Communications Medicine

Volume: 5, P: 1-16
Generating giant and tunable nonlinearity in a macroscopic mechanical resonator from a single chemical bond

Macroscopic mechanical systems typically respond linearly to external force, and generating nonlinearity is challenging. Here, the authors generate nonlinearity in a macroscopic mechanical resonator by linking it to a gold contact and exploiting the anharmonicity in the chemical bonding interactions.

Pu Huang
Jingwei Zhou
Jiangfeng Du
ResearchOpen Access26 May 2016
Nature Communications

Volume: 7, P: 1-7
In situ p-block protective layer plating in carbonate-based electrolytes enables stable cell cycling in anode-free lithium batteries

A p-block metal octoate additive in carbonate electrolytes enables the reversible plating/stripping of alkali metal in anode-free batteries by forming a protective layer with a preferentially adsorbed octoate moiety and uniformly plated p-block metal.

Jie Shi
Toshinari Koketsu
Jiwei Ma
Research02 Sept 2024
Nature Materials

Volume: 23, P: 1686-1694
Ammonia detoxification promotes CD8⁺ T cell memory development by urea and citrulline cycles

Ammonia detoxification is generally thought to occur exclusively in the liver. Here the authors show that ammonia detoxification via the urea and citrulline cycles is utilized by memory CD8⁺ T cells to maintain the longevity.

Ke Tang
Huafeng Zhang
Bo Huang
Research05 Dec 2022
Nature Immunology

Volume: 24, P: 162-173
Electron/infrared-phonon coupling in ABC trilayer graphene

Via Raman and infrared spectroscopy measurements, X. Zan et al. find that rhombohedral ABC trilayer graphene has stronger electron/infrared-phonon coupling than Bernal ABA trilayer graphene.

Xiaozhou Zan
Xiangdong Guo
Guangyu Zhang
ResearchOpen Access29 Feb 2024
Nature Communications

Volume: 15, P: 1-6
Multiplexed nanomaterial-assisted laser desorption/ionization for pan-cancer diagnosis and classification

As cancer is increasingly considered a metabolic disorder, it is postulated that serum metabolite profiling can be a viable approach for detecting the presence of cancer. Here, the authors report a machine learning model using mass spectrometry-based liquid biopsy data for pan-cancer screening and classification.

Hua Zhang
Lin Zhao
Xiangfeng Duan
ResearchOpen Access01 Feb 2022
Nature Communications

Volume: 13, P: 1-11
IL-2 regulates tumor-reactive CD8⁺ T cell exhaustion by activating the aryl hydrocarbon receptor

IL-2 is a classic T cell growth factor. Huang and colleagues demonstrate, however, that chronic IL-2 stimulation leads to a new exhaustion pathway that impairs antitumor immune responses.

Yuying Liu
Nannan Zhou
Bo Huang
Research11 Jan 2021
Nature Immunology

Volume: 22, P: 358-369
Yiqi Juanshen decoction alleviates renal interstitial fibrosis by targeting the LOXL2/PI3K/AKT pathway to suppress EMT and inflammation

Kaiyue Tan
Jingwei Deng
Wenfu Cao
ResearchOpen Access04 Feb 2025
Scientific Reports

Volume: 15, P: 1-15
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Metformin decreases the levels of Bacteroides fragilis while increasing the bile acid GUDCA to antagonize intestinal FXR and improves the metabolic health of humans and mice.

Lulu Sun
Cen Xie
Changtao Jiang
Research05 Nov 2018
Nature Medicine

Volume: 24, P: 1919-1929
Causal contributions of parietal cortex to perceptual decision-making during stimulus categorization

Using a new auditory decision task, neuronal imaging and perturbations, Zhong et al. unveil the critical role of PPC circuits in decision-making when categorizing unknown sensory items.

Lin Zhong
Yuan Zhang
Ning-long Xu
Research29 Apr 2019
Nature Neuroscience

Volume: 22, P: 963-973
Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation

Yu and colleagues report the formation of migrasomes during zebrafish gastrulation. Migrasomes provide signalling molecules to guide the migration of dorsal forerunner cells, thus controlling organ morphogenesis.

Dong Jiang
Zheng Jiang
Li Yu
Research01 Aug 2019
Nature Cell Biology

Volume: 21, P: 966-977
Individual differences in attention and working memory modulate the process of tone merging: evidence from Macau Cantonese

Han Wang
Fei Gao
Jingwei Zhang
ResearchOpen Access02 Aug 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-13
Effect of Qiangji Jianli decoction on mitochondrial respiratory chain activity and expression of mitochondrial fusion and fission proteins in myasthenia gravis rats

Jingwei Song
Xiaowen Lei
Zhiwei Chen
ResearchOpen Access05 Jun 2018
Scientific Reports

Volume: 8, P: 1-12
Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8⁺ T-cell memory development

Zhang et al. show that ketogenesis-derived β-hydroxybutyrate (BHB) epigenetically modifies H3K9 of Foxo1 and Ppargc1a to regulate Pck1, which in turn controls metabolic flux and CD8⁺ memory T-cell development.

Huafeng Zhang
Ke Tang
Bo Huang
Research23 Dec 2019
Nature Cell Biology

Volume: 22, P: 18-25
Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment

Xiang Dong
Chunlu Li
Liu Cao
ResearchOpen Access11 Nov 2023
Oncogene

Volume: 43, P: 92-105
De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity

Jingwei Liu
Tingting Zhou
Liu Cao
ResearchOpen Access20 Apr 2023
Oncogene

Volume: 42, P: 1843-1856
COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan

Hong Liang
Xuanxuan Nian
Xiao-Ming Yang
ResearchOpen Access09 Dec 2022
Cell Discovery

Volume: 8, P: 1-14
Control theory illustrates the energy efficiency in the dynamic reconfiguration of functional connectivity

A framework that allows for the statistical investigation of the dynamic aspect of functional connectivity derived from resting-state fMRI is developed that is shown to complementarily predict individual differences in behavioral measurements compared to existing approaches.

Shikuang Deng
Jingwei Li
Shi Gu
ResearchOpen Access01 Apr 2022
Communications Biology

Volume: 5, P: 1-12
Structure and function analysis of a potent human neutralizing antibody CA521^FALA against SARS-CoV-2

Song et al describe and identify monoclonal antibodies that target the SARSCoV-2 Spike protein, including CA521FALA, which demonstrated neutralising potential in vivo and in vitro. They performed structural analysis, which revealed that CA521FALA recognizes an epitope overlapping with angiotensin converting enzyme 2 (ACE2)-binding sites in SARS-CoV-2 Spike protein therefore making it a promising therapeutic antibody.

Deyong Song
Wenbo Wang
Changlin Dou
ResearchOpen Access23 Apr 2021
Communications Biology

Volume: 4, P: 1-11

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