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Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion

Striatonigral neurons comprise diverse subtypes, yet their specific roles in locomotion regulation are not fully understood. Here, authors demonstrate that the Calb1+ subtype promotes locomotion, while the Kremen1+ subtype terminates ongoing movement by inhibiting the activity of Aldh1a1+ dopaminergic neurons via GABBR1 receptors.

Jie Dong
Lupeng Wang
Huaibin Cai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-19
Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction

2- arachidonoylglycerol (2-AG), an abundant endocannabinoid in the brain, regulates diverse neural functions. Here, the authors identified four loss-of-function mutations in dicylglycerol lipase β (DAGLB) from six patients with early onset Parkinsonism. In mice, loss of DAGLB in dopamine neurons reduced neuronal activity and impaired locomotor function and augmentation of 2-AG levels boosted neuronal activity and rescued locomotor deficits.

Zhenhua Liu
Nannan Yang
Beisha Tang
ResearchOpen Access17 Jun 2022
Nature Communications

Volume: 13, P: 1-16
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

Whole-genome sequence analysis identifies five independent risk loci for Lewy body dementia and demonstrates overlapping genetic architecture with Alzheimer’s and Parkinson’s diseases.

Ruth Chia
Marya S. Sabir
Sonja W. Scholz
Research15 Feb 2021
Nature Genetics

Volume: 53, P: 294-303
Risk assessment of the top 50 drugs associated with drug-induced orthostatic hypotension: a disproportionality analysis of the FAERS and JADER databases

Gaocan Ren
Xiansu Chi
Xiaochang Ma
ResearchOpen Access26 Mar 2025
Scientific Reports

Volume: 15, P: 1-14
Durability analysis of metakaolin recycled concrete under sulphate dry and wet cycle

Chuheng Zhong
Dongping Wang
Yuan Xiao
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-23
Profiling complex repeat expansions in RFC1 in Parkinson’s disease

Pilar Alvarez Jerez
Kensuke Daida
Kimberley J. Billingsley
ResearchOpen Access24 May 2024
npj Parkinson's Disease

Volume: 10, P: 1-4
Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairment

Xue-Feng Ding
Xiang Gao
Jinhui Chen
ResearchOpen Access13 May 2016
Scientific Reports

Volume: 6, P: 1-11
Characterizing a complex CT-rich haplotype in intron 4 of SNCA using large-scale targeted amplicon long-read sequencing

Pilar Alvarez Jerez
Kensuke Daida
Kimberley J. Billingsley
ResearchOpen Access26 Jul 2024
npj Parkinson's Disease

Volume: 10, P: 1-8
A comprehensive risk assessment method for hot work in underground mines based on G1-EWM and unascertained measure theory

Xiaoqiang Ding
Xiangliang Tian
Jinhui Wang
ResearchOpen Access13 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci

Ece Bayram
Paolo Reho
Ruth Chia
ResearchOpen Access20 Feb 2024
npj Parkinson's Disease

Volume: 10, P: 1-9
ALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

Jing Pan
Jia Yu
Huaibin Cai
ResearchOpen Access05 Mar 2019
Scientific Reports

Volume: 9, P: 1-14
Exploring dementia and neuronal ceroid lipofuscinosis genes in 100 FTD-like patients from 6 towns and rural villages on the Adriatic Sea cost of Apulia

Celeste Sassi
Rosa Capozzo
Giancarlo Logroscino
ResearchOpen Access18 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice

Carmelo Sgobio
Lixin Sun
Huaibin Cai
ResearchOpen Access19 Mar 2019
Scientific Reports

Volume: 9, P: 1-14
Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging

Allissa A. Dillman
Elisa Majounie
Mark R. Cookson
ResearchOpen Access04 Dec 2017
Scientific Reports

Volume: 7, P: 1-12

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Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion

Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

Risk assessment of the top 50 drugs associated with drug-induced orthostatic hypotension: a disproportionality analysis of the FAERS and JADER databases

Durability analysis of metakaolin recycled concrete under sulphate dry and wet cycle

Profiling complex repeat expansions in RFC1 in Parkinson’s disease

Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairment

Characterizing a complex CT-rich haplotype in intron 4 of SNCA using large-scale targeted amplicon long-read sequencing

A comprehensive risk assessment method for hot work in underground mines based on G1-EWM and unascertained measure theory

Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci

ALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

Exploring dementia and neuronal ceroid lipofuscinosis genes in 100 FTD-like patients from 6 towns and rural villages on the Adriatic Sea cost of Apulia

Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice

Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging

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