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Maintaining electrode performance under high power is a major challenge for batteries. Here, authors develop a porous organic framework electrode that intermittently applies low currents to release trapped ions, enabling a repeatable capacity-refreshing strategy and over 60,000 cycles at 20 C-rate.

Here, the authors report that introducing βcyclodextrins (CD) as anion-receptors into Zn(OTf)2 aqueous electrolyte could significantly optimize the Zn anode SEI structure for achieving stable ZIB.

The SMN protein recognizes symmetric dimethylarginine by its Tudor ___domain, and SMN deficiency leads to spinal muscular atrophy. Here, Liu et al. discover a small molecule that binds to the SMN Tudor ___domain and disrupts the interaction between SMN and RNA Polymerase II.

MAPK-driven tumorigenesis is often related to epithelial dedifferentiation but the regulatory mechanism is less clear. Here, the authors show that MAPK activation upregulates USP15 to promote deubiquitylation and stability of TBX3, a transcription factor implicated in thyroid development and differentiation, driving tumorigenesis in a BRAFV600E thyroid tumor model.

Owens et al. reported PFI-7, a selective and potent antagonist of GID4 of the CTLH E3 ligase complex, which enables identification of human GID4 targets. This study provides valuable insights into GID4 functions and a powerful tool for advancing new targeted protein degradation strategies.

This study presents an iodine sensor fabricated using AgI-functionalized graphene, which exhibits fast response and recovery times with an ultralow detection limit, surpassing safety standards and outperforming commercial counterparts

Cholesterol lowering medication positively affects anti-cancer immune response, but the underpinning mechanism is not fully known. Here authors show that the effect is mediated by specific cholesterol binding motifs in STING, a key mediator of inflammation, via regulating its trafficking to Golgi.

Discovery of a chemical probe targeting the PWWP ___domain of NSD2 reveals insight into mechanisms that govern NSD2 localization. The compound and its negative control represent valuable tools for further defining NSD2 biology.

The authors investigate how the transcription machinery selects the correct direction to produce coding transcripts. Their results propose a universal mechanism by which Integrator licenses bidirectional transcription to determine the direction of eukaryotic pre-mRNA transcription.

In this work, the authors identify regulators of actin filament assembly involved in chiral organisation of the actin cytoskeleton in single cells and chiral alignment of cells in groups. This provides insights into how actin-driven chirality underlies tissue and organ asymmetry.

Increasing evidence suggests that antigen presentation by B cells is critical to the initiation of autoimmunity. Here, the authors demonstrate that tolerance breakdown is initiated outside of germinal centres and that B cells can directly instruct T cells to break tolerance and propagate autoimmune responses.

STING ER exit is the rate-limiting step in STING signaling, but the mechanism that drives this process is not understood. Paludan and colleagues identify CxORF56, called STEEP here, as a positive regulator of STING signaling.

The function of METTL3 and RNA methylation is important in various biological processes. Here the authors show that METTL3 is reduced in childhood asthma patients and that conditional knockout of Mettl3 in mouse myeloid cells enhances Th2 response and allergic asthma associated with changes in macrophage function.

Here a conformality-assisted tracing method is proposed to devise free-form and three-dimensional conformal metamaterials, featuring accuracy and efficiency in handling complex geometry and adaptability to various diffusion and wave fields.

While earthquakes are known to trigger landslides and initiate hazard cascades, the authors show that landslide hazard cascades can instead trigger earthquakes by increasing stresses on faults through direct loading and pore pressure diffusion.

The use of an allosteric drug-design method resulted in the identification of a first-in-class cellularly active SIRT6 activator that induces cell-cycle arrest in the G₀–G₁ phase, thus suppressing proliferation in human hepatocellular carcinoma cells.

Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inflammatory response to SARS-CoV-2 infection.

N⁶-methyladenosine (m⁶A) is an abundant eukaryotic RNA modification that regulates mRNA stability. Biochemical analysis and crystallographic visualization of m⁶A-YTHDC1 interactions establish this YTH family member as an m⁶A reader and explain its RNA consensus sequence selectivity.

Structural biology, complemented by biochemistry experiments and RNA-binding assays show that the Gemin5 C-terminal region adopts a decamer architecture. Gemin5 decamerization is essential for its role in regulating mRNA translation.

Photonic crystals are often prepared by assembly of particles into periodically arranged structures, but it is challenging to fabricate these materials using lignin nanoparticles. Here, the authors report the use of centrifugation to fabricate photonic crystals with rainbow structural colors.

Utilizing soft pumps in soft robotics is an attractive approach to endow untethered soft robots with muscle-like actuation. Here, the authors report bio-inspired soft electronic pumps as driving power sources to drive actuation and self-healing in untethered soft robotics.

It is known that genotoxic stress induces high levels of ROS and deplete cellular glutathione stores. Here, Cao et al. uncover a β-catenin-dependent TCF/LEF-independent mechanism that promotes histone-mediated transcriptional activation of glutathione synthesis.

Xie et al. show that efficient miRNA biogenesis in Arabidopsis requires the assembly of pre-miRNA processing bodies mediated by SERRATE phase separation.

The role of common fragile site associated genes such as FATS in the immune system is unclear. Here the authors show that deletion of Fats in a mouse tumour model leads to reduced tumour growth and change of macrophage phenotype from an M2-like to M1-like function.

The mechanisms regulating fungal-algal interactions during the formation of lichen symbioses are not clear. Here, Wang et al. establish conditions conducive to symbiotic interactions and lichen differentiation using a fungus amenable to genetic manipulation, showing the importance of a MAP kinase in lichen development.

A structurally diverse set of epigenetic reader proteins can recognize methylated lysine residues on histones. Here the authors show that recognition of trimethyllysine occurs through a combination of favourable cation–πinteractions and the release of water molecules occupying the aromatic cages of reader proteins.

A gene therapy phase 1 trial in patients with β-thalassemia shows transplantation of autologous CD34⁺ cells transduced with a lentiviral globin vector after reduced-intensity conditioning achieves long-term engraftment, albeit not transfusion independence, with benign clonal expansions, warranting cautious monitoring of patients.

This study shows a self-powered deep-sea current measurement system using a triboelectric nanogenerator (TENG) that measures currents from 0.02 to 6.69 m/s and withstands over 45 MPa pressure. Successful operation at 4531 m depth in the South China Sea is demonstrated.

Cathepsin L mediates proteolysis of the histone H3 tail and is a factor in cell-cycle progression and cellular differentiation. Adams-Cioabaet al. report crystal structures of an inactive mutant of the protease complexed with substrate peptides, and find that it is highly accommodating of modified substrates.

The negative regulatory effects of phosphatases are sometimes altered in cancer, but the mechanisms that mediate this effect remain undefined. Here, the authors show that miR-508 suppresses multiple phosphatases, resulting in constitutive activation of the PI3K/Akt pathway.

Chromodomains in chromatin-associated proteins act as ‘readers’ of methylated lysines within histones. Structural and computational design led to the identification of UNC3866, a potent, cell-active peptide-based inhibitor of the methyllysine reading functions of CBX and CDY chromodomains.

Crystal structures of FEM1C in apo and in complex with a C-degron ending with arginine reveal a binding pocket in FEM1C that recognizes C-degrons and the essential role of C-terminal arginine for recognition.

Symmetric dimethylation of the human RNA polymerase II C-terminal ___domain residue R1810 by the protein arginine methyltransferase 5 (PRMT5) directly recruits the protein survival of motor neuron (SMN) and indirectly recruits the helicase senataxin to resolve R-loops and promote transcription termination.

Smart sensors are important components in the development of touchless human-machine interaction systems. Here, the authors describe a smart 3D porous crystalline organic cage-based system that exhibits remarkable responsiveness to fingertip humidity, contributing to the advancement of touchless human-machine interaction technology.

The adult zebrafish heart is capable of regeneration but the molecular mechanisms are poorly understood. Here the authors show that chromatin remodeling factor Brg1 represses cyclin-dependent kinase inhibitors to promote myocardial regeneration.

RNA-binding proteins (RBPs) regulate RNA activity and are implicated in haematopoietic malignancies, but their role in myeloid cell specification is unclear. Here, the authors show a role for the RBP KSRP in promoting granulocyte fate over monocyte fate through the biogenesis of miR-129 and a decrease in RUNX1.

Mammalian RPRD proteins bind the phosphorylated CTD of RNA pol II with different affinities. Structural elucidation and characterization of their CTD interaction domains reveal the basis of RPRD binding preferences and a role in directing CTD dephosphorylation.