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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

The molecular mechanism underlying how lithocholic acid recapitulates the lifespan and healthspan benefits of calorie restriction is revealed to involve TULP3, sirtuins, v-ATPase and AMPK.

Qi Qu
Yan Chen
Sheng-Cai Lin
ResearchOpen Access18 Dec 2024
Nature

Volume: 643, P: 201-209
Efficacy, immunogenicity and safety of CoronaVac® in children and adolescents aged 6 months to 17 years: a multicenter, randomized, double-blind, placebo-controlled phase III clinical trial

In this randomized, placebo-controlled phase 3 clinical trial, the authors assess efficacy, immunogenicity, and safety of the inactivated SARS-CoV-2 vaccine CoronaVac in children and adolescents aged 6 months to 17 years. The study was carried out in Chile, South Africa, Malaysia, and the Philippines, and coincided with the emergence of the Omicron variant.

Qianqian Xin
Kaiqin Wang
Gang Zeng
ResearchOpen Access06 Aug 2024
Nature Communications

Volume: 15, P: 1-10
The associations of physical activity patterns and the triglyceride-glucose index in US adults: a secondary data analysis of NHANES (2007–2018)

JinYe Zhang
YiLin Yang
Bin Yu
ResearchOpen Access18 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

A small-molecule aldolase inhibitor, aldolazin is reported and shown to selectively activate the lysosomal pool of AMPK, which has glucose-lowering effects in rodents.

Chen-Song Zhang
Mengqi Li
Sheng-Cai Lin
ResearchOpen Access10 Oct 2022
Nature Metabolism

Volume: 4, P: 1369-1401
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

Chen et al. report that the immune modulatory metabolite itaconic acid selectively inhibits the activity of TET DNA dioxygenases to repress the inflammatory responses.

Lei-Lei Chen
Carmen Morcelle
Dan Ye
Research07 Mar 2022
Nature Cell Biology

Volume: 24, P: 353-363
Molecular hallmarks of heterochronic parabiosis at single-cell resolution

A transcriptomics study demonstrates cell-type-specific responses to differentially aged blood and shows young blood to have restorative and rejuvenating effects that may be invoked through enhanced mitochondrial function.

Róbert Pálovics
Andreas Keller
Tony Wyss-Coray
Research02 Mar 2022
Nature

Volume: 603, P: 309-314
A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

A single-cell transcriptomic atlas across the lifespan of the mouse, denoted Tabula Muris Senis, provides molecular information about the hallmarks of ageing in a range of tissues and cell types.

Nicole Almanzar
Jane Antony
James Zou
Research15 Jul 2020
Nature

Volume: 583, P: 590-595
Ageing hallmarks exhibit organ-specific temporal signatures

Bulk RNA sequencing of organs and plasma proteomics at different ages across the mouse lifespan is integrated with data from the Tabula Muris Senis, a transcriptomic atlas of ageing mouse tissues, to describe organ-specific changes in gene expression during ageing.

Nicholas Schaum
Benoit Lehallier
Tony Wyss-Coray
Research15 Jul 2020
Nature

Volume: 583, P: 596-602
A density functional theory study of high-performance pre-lithiated MS₂ (M = Mo, W, V) Monolayers as the Anode Material of Lithium Ion Batteries

Tingfeng Liu
Zhong Jin
Youyong Li
ResearchOpen Access23 Apr 2020
Scientific Reports

Volume: 10, P: 1-7
Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells

Binghua Liu
Weiyan Wang
Ke Liu
ResearchOpen Access03 Mar 2021
Cell Death & Disease

Volume: 12, P: 1-14
Erratum: Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis

Lihua Shi
Jacek Bielawski
Jianru Zuo
Amendments and Corrections04 Feb 2008
Cell Research

Volume: 18, P: 324
Silicon Mode-Selective Switch via Horizontal Metal-Oxide-Semiconductor Capacitor Incorporated With ENZ-ITO

Weifeng Jiang
Jinye Miao
Tao Li
ResearchOpen Access28 Nov 2019
Scientific Reports

Volume: 9, P: 1-12
Inhibition of extranodal NK/T-cell lymphoma by Chiauranib through an AIF-dependent pathway and its synergy with L-asparaginase

Tianxiao Gao
Jieye Huang
Zhiming Li
ResearchOpen Access09 May 2023
Cell Death & Disease

Volume: 14, P: 1-14
Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK

Ruoxuan Bao
Yongmei Meng
Yongjun Dang
ResearchOpen Access20 Oct 2021
Cell Death & Disease

Volume: 12, P: 1-13
Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation

Yi Wu
Keshi Chen
Xingguo Liu
Research25 May 2022
Cell Death & Differentiation

Volume: 29, P: 2316-2331
Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis

Lihua Shi
Jacek Bielawski
Jianru Zuo
Research04 Dec 2007
Cell Research

Volume: 17, P: 1030-1040
Influence of Ru on structure and corrosion behavior of passive film on Ti-6Al-4V alloy in oil and gas exploration conditions

Qiang Liu
Hongtao Liu
Cheng-xian Yin
ResearchOpen Access05 Oct 2022
Scientific Reports

Volume: 12, P: 1-17

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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

Efficacy, immunogenicity and safety of CoronaVac® in children and adolescents aged 6 months to 17 years: a multicenter, randomized, double-blind, placebo-controlled phase III clinical trial

The associations of physical activity patterns and the triglyceride-glucose index in US adults: a secondary data analysis of NHANES (2007–2018)

The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

Ageing hallmarks exhibit organ-specific temporal signatures

A density functional theory study of high-performance pre-lithiated MS₂ (M = Mo, W, V) Monolayers as the Anode Material of Lithium Ion Batteries

Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells

Erratum: Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis

Silicon Mode-Selective Switch via Horizontal Metal-Oxide-Semiconductor Capacitor Incorporated With ENZ-ITO

Inhibition of extranodal NK/T-cell lymphoma by Chiauranib through an AIF-dependent pathway and its synergy with L-asparaginase

Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK

Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation

Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis

Influence of Ru on structure and corrosion behavior of passive film on Ti-6Al-4V alloy in oil and gas exploration conditions

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