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The authors make local heterogeneous dipolar structures in PbHfO3-based antiferroelectric ceramics, which exhibit a recoverable energy density of 20.04 J cm⁻³ accompany with an efficiency of 90.5%.

The Crabtree effect affects yeast-based bioproduction. Here, the authors report the development of a Crabtree-negative yeast through introducing the sucrose phosphorolysis pathway, deletion of the phosphoglucose isomerase gene PGI1, and engineering a synthetic energy system to regulate NADH/NAD⁺ ratio.

Wzc is the master regulator of the biosynthesis and export of bacterial capsular polysaccharides and exopolysaccharides. Here, the authors report cryoEM structures of intermediate states and provide insights into phosphorylation and transmembrane signalling.

Chromosome synapsis is an essential process during meiotic recombination and gametogenesis. Here they show that TRIP13-dependent removal of HORMAD1 and HORMAD2 from synapsed chromosome axes during meiotic prophase is crucial for female fertility, as it prevents aberrant chromosome asynapsis checkpoint activation and unintended oocyte elimination.

Cycling positive electrodes at high voltages leads to structural instability and capacity decay. Here, authors report a cationic defective electrode, Na_3.2□_0.8Co_0.5Fe_0.5V(PO_3.9F_0.1)₃, through fluorine doping with enhanced stability, reversible capacity, and fast Na⁺ (de)intercalation.

The authors make multi-oriented nanodomain in BiFeO3-based ceramics via the strategic design of a dipolar region with high resilience to electric fields, achieving high energy storage density of 12.2 J cm−3 and energy storage efficiency of 90.1%.

Cheng et al. developed an autophagy-based targeted protein degradation platform by conjugating polyethylenimine to antibodies, designated as autophagy-inducing antibodies, which can degrade proteins in vivo and enable the degradation of multiple proteins at the same time.

Fan, Shang, Song, Chen et al. identify the Integrator–PP2A complex (INTAC) as a key regulator of cancer cell sensitivity to BET inhibitors through directly interacting with the RACK7–KDM5 complex to orchestrate epigenetic silencing in a catalytic-independent manner.

A p-block metal octoate additive in carbonate electrolytes enables the reversible plating/stripping of alkali metal in anode-free batteries by forming a protective layer with a preferentially adsorbed octoate moiety and uniformly plated p-block metal.

The Wzc–Wza complex forms part of the bacterial extracellular polysaccharides synthesis machinery, where cycling of the Wzc between phosphorylation states is crucial to both synthesis and export. Here the authors report the structure of the Wzc octamer and provide insight into its regulation through phosphorylation.

Zhou et. al. report the interim results of the randomized phase III GEMSTONE-302 trial, showing the overall survival benefits of first-line treatment with the PD-L1 inhibitor sugemalimab versus placebo in combination with chemotherapy, in patients with NSCLC.

SOSS–INTAC stimulates promoter-proximal termination of transcription and attenuates R-loops associated with paused RNA polymerase II to prevent R-loop-induced genome instability.

In laser-driven inertial fusion, finding optimal driving pressure is a major challenge. Here, the authors use a 100 kJ SG laser and a hybrid-drive scheme to demonstrate such driving pressure with the help of the direct-drive laser such that the indirect-drive radiation ablation pressure is turned into a well-smoothed hybrid-drive pressure much greater than the radiation ablation pressure.

Compared to monovalent lithium or sodium ions, the reversible insertion of multivalent ions into battery electrodes has proved challenging. An aliovalent doping strategy involving reversible Mg²⁺ and Al³⁺ insertion in anatase TiO₂ is now reported.

Exploring an active and cost-effective catalyst for alkaline hydrogen evolution reaction remains elusive to date. Here, the authors report the platinum single-atoms doped ruthenium/ruthenium oxides showing distinctly enhanced catalytic performance.

Dynamin mediates the fission of vesicles during endocytosis. Here, the authors report the cryoEM structure of a super-constricted two-start dynamin 1 filament- one of the two known helical forms of dynamin, with insights into the molecular mechanisms of dynamin-mediated membrane scission.

How the REGγ-proteasome pathway is regulated during the cell cycle or genotoxic insults remains unclear. Here, the authors show that NIP30 acts as a molecular switch to regulate the REGγ-proteasome activity and may provide an approach to combat drug-resistant tumours lacking functional p53.

Different deubiquitinases are associated to cancer development. Here, the authors show that PPARgamma is stabilized by USP22-mediated deubiquitination leading to lipid accumulation and promoting hepatocellular carcinoma.

The study presents data from moorings in the Challenger Deep, the deepest known hadal trench in the world, showing a three-layer circulation structure, modulated by deep-water intrusion, topography and turbulent mixing.

The observed deep-water overflow transport from the Pacific into the South China Sea has increased by 9% since 2009. This finding may have broad implications for the overturning circulations and biogeochemical processes in this region.

Skull base chordomas are treated with surgery and chemotherapy but often recur due to incomplete resection, understanding the molecular underpinnings of the tumours may provide additional therapeutic strategies. Here, the authors carry out whole genome sequencing of 80 skull base chordoma tumours and identify the SWI/SNF component—PBRM1—as a frequently mutated gene.

Turbulent mixing is critically important for ocean circulation, but their latitudinal distribution are poorly known. Here, the authors show that the generation mechanism of the W-shaped distribution of turbulent mixing in the tropical-extratropical Pacific is latitude dependent.

The authors show that the presence of strong ocean internal tides in the South China Sea suppresses tropical cyclone intensification, mitigating their impacts on the highly populated surrounding regions.

Based on two high-resolution simulations, the authors find that submesoscale eddies significantly boost poleward oceanic heat transport in Antarctic waters by strengthening transport capability of mesoscale eddies through inverse energy cascade.

A hierarchically designed polymer nanofibre-based film produced by a scalable electrospinning process enables selective mid-infrared emission and effective sunlight reflection, and thus realizes an excellent all-day radiative cooling performance.

Tropical cyclones can significantly reduce the extent of the Changjiang River plume and induce surface salinification, with Tropical Cyclone Lekima in 2019 causing up to 6.5 psu salinification and an 83% contraction of the plume, according to a combination of satellite and in-situ observations and modelling experiments.

This Review explores the genetic basis of diversification and adaptation in non-human primates, including their responses to ecological and environmental changes.

Postmortem analyses provide useful information for COVID-19 etiology. Here the authors profile 22 deceased severe COVID-19 patients with transcriptomic and histological approaches to find correlations between the presence of viral antigens with lymphocyte suppression yet myeloid activation, hinting distinct functions of these cells during pathogenesis.

Subgrade settlement is a serious distress which poses a huge threat to the service life and operation safety of roads. Here, authors propose the application of ground-penetrating radar as technical solution for the quality evaluation of ground improvement in soft soil subgrade reinforcement engineering.

Structural degradation in manganese oxides leads to unstable activity during long-term cycles. Herein, authors demonstrated that reduced unstable O 2p holes and the short interlayer distance of layered lithium manganese oxide are favorable for excellent electrocatalytic stability and activity.

Lipid metabolism has been linked to iNKT function largely as it impacts processing and presentation of lipids they recognize. Here the authors show that iNKT-intrinsic lipid biosynthesis is important for their function but is impaired in tumors, and its restoration with PPARγ agonist drugs promotes anti-tumor iNKT response.

There are difficulty of achieving saturated poling and understanding of multi-scale structures in (K, Na)NbO₃ ceramics. Here, the authors find atomic-scale polymorphic distortion and micrometer-scale high-density thin striped domains, which is key for high saturated poling.

Long intergenic non-coding RNAs have been linked to cancer development. Here the authors, using RNA-seq and genomic amplification data, identify lincRNAs deregulated in hepatocellular carcinoma and propose that Linc01138 is stabilized by IGF2BP1/3 in the cytoplasm, and binds and stabilizes the methyltransferase PRMT5 by preventing the association of PRMT5 to the E3 ubiquitin ligase CHIP.

The use of a dimensionally graded 2D perovskite interface and passivation results in perovskite solar cells with very low photovoltage loss.

Gestational exposure to ambient fine particles increases the risk of stillbirth, but the related disease burden is unknown, particularly in low- and middle-income countries (LMICs). Here, the authors combine state-of-the-art estimates on stillbirths, and multiple exposure–response functions to evaluate the burden in 137 countries.

Exploring efficient electrocatalysts with fundamental understanding of the reaction mechanism is important for CO₂ electroreduction. Here, the authors report a strategy of promoting water dissociation to achieve high solar to chemical conversion and identify key surface species for the reaction.

An innovative technique uses ultrafast below-bandgap electric-field pulses to induce and probe an insulator–metal transition in an oxide thin film on which a metamaterial structure has been deposited.

The functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internalization.