Nature Search

Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma

Pathogenic T helper type 2 cells (pTh2) are involved in allergic asthma and secrete high levels of IL-5 and IL-13. Here, using HDM challenged mice and developing an in vitro pTh2 culture system, the authors investigate the function of epigenetic modifications in pTh2 cells showing that HDAC1 limits the pathogenicity of pTh2 cells and scRNA analysis of these cells indicates two subsets in the lungs.

Matarr Khan
Marlis Alteneder
Nicole Boucheron
ResearchOpen Access15 Mar 2025
Nature Communications

Volume: 16, P: 1-21
Endrov: an integrated platform for image analysis

Johan Henriksson
Jürgen Hench
Thomas R Bürglin
Correspondence30 May 2013
Nature Methods

Volume: 10, P: 454-456
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Helleday and colleagues describe a nanomolar MTHFD2 inhibitor that causes replication stress and DNA damage accumulation in cancer cells via thymidine depletion, demonstrating a potential therapeutic strategy in AML tumors in vivo.

Nadilly Bonagas
Nina M. S. Gustafsson
Thomas Helleday
ResearchOpen Access28 Feb 2022
Nature Cancer

Volume: 3, P: 156-172
Single-cell transcriptomics reveal transcriptional programs underlying male and female cell fate during Plasmodium falciparum gametocytogenesis

P. falciparum (malaria) transmission includes the development of male and female parasite forms called gametocytes, which are taken up by the Anopheles mosquito. The authors of this study use single cell transcriptomics to define the transcriptional programs, identify key regulators and predict novel genes, involved in driving the male and female sexual cell fates.

Mubasher Mohammed
Alexis Dziedziech
Johan Ankarklev
ResearchOpen Access26 Aug 2024
Nature Communications

Volume: 15, P: 1-20
Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans

To overcome challenges posted by vast number of GPCR genes and redundancy, the authors disrupted nearly all GPCR-encoding genes in C. elegans, enabling effective examination of GPCR signaling and offering a valuable resource for the research community.

Longjun Pu
Jing Wang
Changchun Chen
ResearchOpen Access18 Dec 2023
Nature Communications

Volume: 14, P: 1-16
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome

Shuijie Li
Wenyu Li
Susanne Schlisio
Amendments and CorrectionsOpen Access08 Sept 2022
Nature Metabolism

Volume: 4, P: 1421
Type I interferon shapes brain distribution and tropism of tick-borne flavivirus

Here the authors combine a multimodal imaging-snRNAseq transcriptomics strategy to provide insight into the distribution of a neurotropic tick-borne flavivirus in the brain, and show that absence of interferon signaling increases infection of resident microglia.

Nunya Chotiwan
Ebba Rosendal
Anna K. Överby
ResearchOpen Access10 Apr 2023
Nature Communications

Volume: 14, P: 1-18
Gene expression variability across cells and species shapes innate immunity

Comparison of transcriptomic data from immune-stimulated cells across different species sheds light on the architecture of the innate immune response.

Tzachi Hagai
Xi Chen
Sarah A. Teichmann
Research24 Oct 2018
Nature

Volume: 563, P: 197-202
Life’s Essential 8 is inversely associated with high-sensitivity C-reactive protein

Lana Hebib
Ángel Herraiz-Adillo
Pontus Henriksson
ResearchOpen Access01 Jul 2024
Scientific Reports

Volume: 14, P: 1-8
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome

Li et al. show how mitochondrial content is regulated when oxygen is depleted, as well as how this process is impaired in cancer types related to the von Hippel–Lindau syndrome.

Shuijie Li
Wenyu Li
Susanne Schlisio
ResearchOpen Access27 Jun 2022
Nature Metabolism

Volume: 4, P: 739-758
Single-cell reconstruction of the early maternal–fetal interface in humans

Transcriptomes of about 70,000 single cells from first-trimester deciduas and placentas reveal subsets of perivascular, stromal and natural killer cells in the decidua, with distinct immunomodulatory profiles that regulate the environment necessary for successful placentation.

Roser Vento-Tormo
Mirjana Efremova
Sarah A. Teichmann
Research14 Nov 2018
Nature

Volume: 563, P: 347-353
Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders

By examining the genetic makeup of Northern Finnish sub-isolate populations, Stoll et al. show association between deletion of a topoisomerase III gene (TOP3B) and both schizophrenia and cognitive impairment. They also uncover a mechanism for the concomitant integration of TOP3β with the fragile X protein FMRP into messenger ribonucleoprotein complexes

Georg Stoll
Olli P H Pietiläinen
Aarno Palotie
Research04 Aug 2013
Nature Neuroscience

Volume: 16, P: 1228-1237
Clinically available predictors of obstructive sleep apnoea requiring treatment in type 2 diabetes patients in primary care

Jonas Agholme
Kim Ahtola
Fredrik Iredahl
ResearchOpen Access13 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection

The role of hypoxia inducible factors in infection and immune response is unclear. Here, the authors study their impact on the regulation of T cells responses during Mycobacteria tuberculosis infection using transcriptomics, flow cytometry and in vivo infection.

Ruining Liu
Victoria Muliadi
Martin E. Rottenberg
ResearchOpen Access05 Sept 2022
Nature Communications

Volume: 13, P: 1-20
The impact of rare protein coding genetic variation on adult cognitive function

Analysis of rare coding variants in the UK Biobank identifies eight genes associated with adult cognitive function, including KDM5B. Rare and common variant signals overlap and contribute additively to the phenotype.

Chia-Yen Chen
Ruoyu Tian
Heiko Runz
ResearchOpen Access25 May 2023
Nature Genetics

Volume: 55, P: 927-938
The HLA-B –21 M/T dimorphism associates with disease severity in COVID-19

Benedikt Strunz
Pouria Momayyezi
Quirin Hammer
ResearchOpen Access01 Nov 2024
Genes & Immunity

Volume: 26, P: 70-74
Clear effects on root system architecture of winter wheat cultivars (Triticum aestivum L.) from cultivation environment and practices

Jonathan E. Cope
Fede Berckx
Martin Weih
ResearchOpen Access15 May 2024
Scientific Reports

Volume: 14, P: 1-13
p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids

Ana Marin Navarro
Robin Johan Pronk
Margareta Wilhelm
ResearchOpen Access23 Jan 2020
Cell Death & Disease

Volume: 11, P: 1-16
Assessment of transmitral and left atrial appendage flow rate from cardiac 4D-CT

Bäck et al. describe a motion tracking algorithm to measure the flow rate through the mitral valve (MV) and the left atrial appendage (LAA) from 4D-CT data. The developed algorithm provided accurate tracking of dynamic cardiac geometries resulting in similar flow rates at the MV and LAA to those measured by 4D flow MRI.

Sophia Bäck
Lilian Henriksson
Tino Ebbers
ResearchOpen Access11 Feb 2023
Communications Medicine

Volume: 3, P: 1-9
Scientific mobilization of keystone actors for biosphere stewardship

Henrik Österblom
Carl Folke
Jane Lubchenco
ResearchOpen Access04 Mar 2022
Scientific Reports

Volume: 12, P: 1-17
Single-cell RNA-sequencing resolves self-antigen expression during mTEC development

Ricardo J. Miragaia
Xiuwei Zhang
Tapio Lönnberg
ResearchOpen Access12 Jan 2018
Scientific Reports

Volume: 8, P: 1-13

Search

Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma

Endrov: an integrated platform for image analysis

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Single-cell transcriptomics reveal transcriptional programs underlying male and female cell fate during Plasmodium falciparum gametocytogenesis

Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans

Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome

Type I interferon shapes brain distribution and tropism of tick-borne flavivirus

Gene expression variability across cells and species shapes innate immunity

Life’s Essential 8 is inversely associated with high-sensitivity C-reactive protein

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome

Single-cell reconstruction of the early maternal–fetal interface in humans

Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders

Clinically available predictors of obstructive sleep apnoea requiring treatment in type 2 diabetes patients in primary care

HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection

The impact of rare protein coding genetic variation on adult cognitive function

The HLA-B –21 M/T dimorphism associates with disease severity in COVID-19

Clear effects on root system architecture of winter wheat cultivars (Triticum aestivum L.) from cultivation environment and practices

p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids

Assessment of transmitral and left atrial appendage flow rate from cardiac 4D-CT

Scientific mobilization of keystone actors for biosphere stewardship

Single-cell RNA-sequencing resolves self-antigen expression during mTEC development

Search

Quick links

Search

Filter By:

Search

Quick links