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In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis

Bulk ex vivo and single-cell in vivo CRISPR knockout screens are used to characterize 680 chromatin factors during mouse hematopoiesis, highlighting lineage-specific and normal and leukemia-specific functions.

David Lara-Astiaso
Ainhoa Goñi-Salaverri
Brian J. P. Huntly
ResearchOpen Access14 Aug 2023
Nature Genetics

Volume: 55, P: 1542-1554

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In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis

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