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Advanced filters: Author: Jonas Alfermann Clear advanced filters

  • Many natural products are produced by non-ribosomal peptide synthetases in an assembly-line fashion. How these molecular machines orchestrate the biochemical sequences has remained elusive. It is now understood that an extended-conformation ensemble is needed to coordinate chemical-transformation steps whereas the biosynthesis directionality is driven by the enzyme’s innate conformational free energies.

    • Xun Sun
    • Jonas Alfermann
    • Haw Yang
    Research
    Nature Chemistry
    Volume: 16, P: 259-268

  • FRET sensors based on the adenylation and peptidyl carrier protein domains of a nonribosomal peptide synthetase illuminate the relationships between conformational dynamics and the catalytic cycle of this multidomain assembly line enzyme.

    • Jonas Alfermann
    • Xun Sun
    • Henning D Mootz
    Research
    Nature Chemical Biology
    Volume: 13, P: 1009-1015