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Showing 1–5 of 5 results
Advanced filters: Author: Jonas Moecking Clear advanced filters

  • Pyroptosis has been implicated in many diseases with aberrant inflammation. Here, Kopp et al. characterize single-chain nanobodies targeting the human gasdermin D protein as tools to inhibit pyroptosis.

    • Anja Kopp
    • Gregor Hagelueken
    • Matthias Geyer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Abemaciclib is a third generation CDK-directed drug used in the treatment of HR + /HER2 negative advanced or metastatic breast cancer. Here the authors demonstrate that members of the Homeodomain-interacting protein kinases (HIPKs) HIPK3 and DYRK1A are also targeted by Abemaciclib.

    • Ines H. Kaltheuner
    • Kanchan Anand
    • Matthias Geyer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • A CalpL–CalpT–CalpS cascade mediated by cyclic oligoadenylates is identified as a mechanism to detect viral RNA and activate subsequent antivirus responses in microorganisms.

    • Christophe Rouillon
    • Niels Schneberger
    • Gregor Hagelueken
    Research
    Nature
    Volume: 614, P: 168-174