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WHaloCaMP is a chemigenetic calcium indicator that can be combined with different rhodamine dyes for multiplexed or FLIM imaging in vivo, as demonstrated for calcium imaging in neuronal cultures, brain slices, Drosophila, zebrafish larvae and the mouse brain.

Plastic pollution severely threatens the resilience of nature. Here, the authors utilize the spore-forming, polymer-degrading bacteria, Bacillus subtilis, as a living filler to develop biocomposite thermoplastic polyurethane with improved mechanical properties and biodegradation.

A silicon-germanium integrated homodyne detector with a footprint of 0.84 mm² is fabricated to enhance the speed performance of quantum light measurement. It can measure the spectrum of squeezing from 100 MHz to 9 GHz of a squeezed light source.

Excitons in various spin and valley configurations control the optical properties of ultrathin transition metal dichalcogenides. Here, the authors develop theoretical and experimental methods to determine the exciton g-factors for all possible spin-valley configurations of excitons in monolayer and bilayer WSe₂, including valley-indirect excitons.

The fly male germline stem cells undergo asymmetric division, with old histones H3 and H4 preferentially retained in the daughter stem cell. The mechanisms that contribute to this outcome are revealed using super-resolution microscopy and DNA fiber analyses.

The homeostasis of plant NLRs needs to be tightly regulated to avoid triggering autoimmunity. Here, the authors revealed that ___domain shuffling can transfer pre-existing ubiquitination regulatory mechanism to control homeostasis of plant paired NLR complex harboring integrated domains.

Neural crest cells are highly multipotent stem cells, but it remains unclear how their fate restriction to specific fates occurs. Here, the authors show in zebrafish that broad multipotency is retained even after migration, suggesting that fate restriction occurs directly, but dynamically.

Enhancing quantum coherence is key for developing applied hybrid quantum technologies. Here, the authors optimize quantum coherence in exciton-polariton condensates by minimizing, via spatial separation, the condensate’s interaction with surrounding excitons and free carriers, thereby paving the way for integrating polariton systems into hybrid quantum devices.

Si color centers offer promising quantum technology applications, but their interaction with electric fields has not been explored. Here the authors report electrical manipulation of telecom emitters in Si by fabricating lateral diodes with an integrated ensemble of G centers in commercial Si on insulator wafer.

Some lake basins in the polar regions of Titan may be craters from nitrogen vapour explosions due to past warming, according to analysis of their morphology in comparison to terrestrial explosion craters from magma–water interaction.

Synchrotron and inverse-Compton emission provide evidence for a reverse-shock origin of the high-energy emission from a gamma-ray burst, GRB 180720B. The polarization of the optical emission originating from the reverse shock suggests a turbulent shock that is amplified by the magnetic field in the relativistic ejecta.

Multiplexed analyses of near single EVs is currently challenging. Here the authors report the method MASEV, multiplexed analysis of EVs, to interrogate thousands of individual EVs during 5 cycles of multi-channel fluorescence staining for 15 EV biomarkers.

JWST spectroscopy confirms redshifts for two very luminous galaxies with z > 11, and also demonstrates that another candidate with suggested z ≈ 16 instead has z = 4.9.

A new culture system makes it possible to grow mouse embryos and study their development outside the uterus up to the point of late organogenesis.

Using engineered cardiac tissues, Fleischer, Nash et al. found that patients with lupus-mediated cardiac damage have unique autoantibodies that can independently alter tissue function. They also identified autoantibodies associated with heart injury.

A micro-fabricated Penning trap that operates at a 3 T magnetic field demonstrates full quantum control of an ion and the ability to transport the ion arbitrarily in the trapping plane above the chip.

Acoustically driven spin control of silicon monovacancies can be used to measure the resonant properties and dynamical strain distribution in lateral overtone bulk acoustic resonators.

The identification of dark states—quantum states that do not interact with photons—in real materials may help to address many unsolved issues in condensed-matter physics. Now, they have been identified in palladium diselenide.

Here, the authors develop a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine candidate and show induction of neutralization antibody titers in mice that are comparable to titers in convalescent sera of patients.

The Annotatability framework analyzes neural network training dynamics to interpret single-cell and spatial omics data. It identifies erroneous annotations and ambiguous cell states, infers trajectories from binary labels and enables signal-aware analysis.

Here the authors present a non-FRET DNA-templated silver nanocluster probe that exhibits a distinct colour switch from green to red upon nuclease digestion, visible under UV excitation, offering a low-cost, effective alternative to fluorescent reporters for detecting nuclease activities.

The researchers present an image sensor that allows every pixel to have independent exposure. It can sample a cell ROI’s fast fluorescence activity with long exposures at different phases, enhancing SNR and temporal resolution for capturing high-speed events.

Design rules for the synthesis of donor–acceptor systems with efficient intramolecular singlet fission are now proposed. These guidelines have been applied to both small molecules and polymeric chains.

Despite their two-dimensional nature, metasurfaces offer flexible and efficient control over the properties of light passing through them. Here, the authors realize chiral silicon-based metasurfaces for applications as polarizers or as emitters of polarized thermal radiation.

JN.1 lineage is a globally dominant variant of SARS-CoV-2. Here, the authors examine structural insights into the BA.2.86 and JN.1 spike dynamics to help understand the mechanisms underlying SARS-CoV-2 infection and its neutralizing-antibody evasion.

Juno’s close flyby of Ganymede on 7 June 2021 allowed the infrared mapping spectrometer JIRAM to observe the surface at unprecedented spatial resolution. JIRAM’s detailed spectroscopic characterization reveals past extensive aqueous alteration on the moon, possibly together with hydrothermal activity.

The rheological properties of the 2021 Cumbre Vieja magma on La Palma, Canary Islands is investigated. The study indicates that this eruption was fueled by magma having among the lowest viscosities observed for mafic systems, and consequently produced lavas that were flowing in the supercritical and possibly turbulent regime.

Photons emitted from a quantum dot typically have slightly different frequencies owing to various sources of noise. Here, the authors suppress the noise, notably the noise arising from the nuclear spins, and demonstrate single-photon emission with a transform-limited optical linewidth.

Ferroelectric vortex-type structures have only been seen in isolated films, leaving electrode effects unexplored. Here, Peters et al. show that the polarisation curling and formation of vortex and flux-closure structures is a generic effect appearing in ultrathin ferroelectric films.

The dentate gyrus and CA3 of the hippocampus are involved in pattern separation. Niibori and colleagues investigate the role of adult hippocampal neurogenesis in pattern separation and find that suppressing adult neurogenesis in the dentate gyrus impairs coding of similar, but not dissimilar contexts.

Optical assembly of nanoparticle structures could open new avenues for manufacturing nanomaterials and devices. Herrmann et al.show the plasmon-induced laser threading of gold nanoparticle strings, enabling them to fabricate precisely assembled 12-nm wide conducting chains.

Monitoring the activity of nuclear reactors requires measuring the neutron distribution in the core efficiently and in real time. Here, the authors present an imaging approach for neutrons and gamma-rays that thanks to a slit-pupil-like design, enables radiations to be visualized directly in operative reactors.

The formation of molecules in binary particle collisions is forbidden in free space, but the presence of an external trapping potential now enables the realization of bound states in ultracold atom–ion collisions.

Pairs of photons in the Laughlin state are created by mimicking a fractional quantum Hall system using the synthetic magnetic field induced by a twisted optical cavity and Rydberg-mediated polariton interactions.

A neural circuit in Drosophila reveals how the fly’s internal sense of heading rotates when it turns.

Jonathan Goldenberg et al. use photographic data and ancestral state reconstruction of 126 viper species to show that substrate type influences the evolution of ventral brightness for efficient heat transfer. Their results suggest that these patterns may have been involved in the diversification of vipers during the Miocene, and highlight the importance of ventral body regions when considering behavioral ecology and evolution.

A single-wavelength genetically encoded sensor of extracellular glutamate is reported. The sensor—iGluSnFR—is bright and photostable under both one- and two-photon illumination and is shown to work for in vivo imaging in worms, zebrafish and mice.