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Showing 1–8 of 8 results
Advanced filters: Author: Jonathan R. Terman Clear advanced filters

  • Terman and colleagues employed a genetic screen in Drosophila to identify the SelR methionine sulfoxide reductase as the enzyme responsible for reversing the Mical-mediated oxidation of actin. Thus, SelR antagonizes the effects of Semaphorin–Plexin–Mical-dependent signalling in vivo.

    • Ruei-Jiun Hung
    • Christopher S. Spaeth
    • Jonathan R. Terman
    Research
    Nature Cell Biology
    Volume: 15, P: 1445-1454

  • Actin-based structures in cells and tissues are built and maintained through a poorly understood balance between assembly and disassembly. Here, our findings provide insights into how factors known to promote these opposing effects dynamically integrate to shape cells and tissue systems.

    • Elena E. Grintsevich
    • Giasuddin Ahmed
    • Jonathan R. Terman
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Grintsevich et al. discover that the redox enzyme Mical oxidizes F-actin to promote binding of the F-actin-severing protein cofilin, and that the synergy of Mical and cofilin is necessary and sufficient for F-actin disassembly in Drosophila.

    • Elena E. Grintsevich
    • Hunkar Gizem Yesilyurt
    • Emil Reisler
    Research
    Nature Cell Biology
    Volume: 18, P: 876-885

  • MICAL Redox enzymes post-translationally modify F-actin to promote its cellular destabilization. Here, the authors present a 3.9Å cryoEM structure of Mical-oxidized F-actin, showing its nucleotide-state dependent dynamic instability and susceptibility to cofilin-induced severing in the presence of inorganic phosphate.

    • Elena E. Grintsevich
    • Peng Ge
    • Emil Reisler
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Semaphorins and their receptors, plexins, relay guidance information to neurons during development and regulate actin dynamics through an unknown mechanism. Recently, proteins of the Mical family of enzymes have been found to associate with plexins; here, Mical is reported to directly link semaphorins and their plexin receptors to the precise control of actin filament dynamics.

    • Ruei-Jiun Hung
    • Umar Yazdani
    • Jonathan R. Terman
    Research
    Nature
    Volume: 463, P: 823-827

  • Metal nanoparticles with dimensions below ten nanometres exhibit plasmon resonances governed by quantum mechanical effects, as probed with electron microscopy and spectroscopy

    • Jonathan A. Scholl
    • Ai Leen Koh
    • Jennifer A. Dionne
    Research
    Nature
    Volume: 483, P: 421-427