Nature Search

Evidence for stone-tool-assisted consumption of animal tissues before 3.39 million years ago at Dikika, Ethiopia

The earliest direct evidence for stone tools is between 2.6 and 2.5 million years old and comes from Gona, Ethiopia. These authors report bones from Dikika, Ethiopia, dated to around 3.4 million years ago and marked with cuts indicative of the use of stone tools to remove flesh and extract bone marrow. This is the earliest known evidence of stone tool use, and might be attributed to the activities of Australopithecus afarensis.

Shannon P. McPherron
Zeresenay Alemseged
Hamdallah A. Béarat
Research12 Aug 2010
Nature

Volume: 466, P: 857-860
Developmental biology: A Rosetta stone for pattern formation in animals?

Jonathan Slack
News & Views02 Aug 1984
Nature

Volume: 310, P: 364-365
Improving care to decrease stone recurrence and opioid use

In 2019, quality improvement has been a central theme throughout leading articles on nephrolithiasis. Real-world outcomes were published on the natural history of stones and residual fragments, patient compliance with medical therapy and treatment-related opioid use. In-depth review of these topics will enhance provider–patient counselling and shape future paradigms in stone disease.

Jonathan G. Pavlinec
Benjamin K. Canales
News & Views24 Dec 2019
Nature Reviews Urology

Volume: 17, P: 75-76
P-type ATPase magnesium transporter MgtA acts as a dimer

Zeinert et al. provide cryo-EM structures of the E. coli Mg²⁺ importer MgtA: unexpectedly, this P-type ATPase is a dimer with an uncommon transmembrane ion-binding site and knotted N-terminus, which are functionally important features.

Rilee Zeinert
Fei Zhou
Doreen Matthies
Research23 Jun 2025
Nature Structural & Molecular Biology

P: 1-11
Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Siew et al. using multi-omic, physiological & imaging approaches have demonstrated that spaceflight causes kidney remodelling, suggesting a contribution to kidney stone formation, & that space radiation causes kidney damage & early signs of dysfunction.

Keith Siew
Kevin A. Nestler
Stephen B. Walsh
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-20
Free hand hitting of stone-like objects in wild gorillas

Shelly Masi
Emmanuelle Pouydebat
Claudio Tennie
ResearchOpen Access15 Jul 2022
Scientific Reports

Volume: 12, P: 1-10
Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

Tamar Alon
Itzhak Hemo
Eli Keshet
Research01 Oct 1995
Nature Medicine

Volume: 1, P: 1024-1028
Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules

Emily Rose
Daniela Lee
Clemens Bergwitz
ResearchOpen Access19 Jun 2019
Scientific Reports

Volume: 9, P: 1-12
Publisher Correction: Free hand hitting of stone-like objects in wild gorillas

Shelly Masi
Emmanuelle Pouydebat
Claudio Tennie
Amendments and CorrectionsOpen Access24 Aug 2022
Scientific Reports

Volume: 12, P: 1
Inferring internal states across mice and monkeys using facial features

Here, the authors created a virtual reality task for monkeys and mice to explore if internal states like attention are similar across species. Their facial expressions during the task were similar, suggesting facial expressions reflect shared internal states.

Alejandro Tlaie
Muad Y. Abd El Hay
Marieke L. Schölvinck
ResearchOpen Access04 Jun 2025
Nature Communications

Volume: 16, P: 1-16
Cavities in Stones

E. W. SWANTON
Research20 Mar 1913
Nature

Volume: 91, P: 59
Cell-free biodegradable electroactive scaffold for urinary bladder tissue regeneration

Cell seeding on scaffolds for regenerative tissue engineering presents a regulatory and manufacturing hurdle. Here, the authors report on the development of a cell free conductive scaffold which can support tissue regeneration without cell seeding, demonstrating application in bladder repair.

Rebecca L. Keate
Matthew I. Bury
Guillermo A. Ameer
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-13
Viral metagenome reveals microbial hosts and the associated antibiotic resistome on microplastics

The combination of metagenome and virus-enriched virome sequencing provides comprehensive profiles of viral communities and their associated antibiotic resistance genes and reveals the factors driving changes in the plastisphere.

Ruilong Li
Xin-Li An
Yong-Guan Zhu
Research14 Jun 2024
Nature Water

Volume: 2, P: 553-565
Earliest Olduvai hominins exploited unstable environments ~ 2 million years ago

Oldupai Gorge, Tanzania is a key site for understanding early human evolution. Here, the authors report a multiproxy dataset from the Western basin of Oldupai Gorge dating to 2 million years ago, enabling the in situ comparison of lithic assemblages, paleoenvironments and hominin behavioral adaptability.

Julio Mercader
Pam Akuku
Michael Petraglia
ResearchOpen Access07 Jan 2021
Nature Communications

Volume: 12, P: 1-15
How Dextrous was Neanderthal Man ?

JONATHAN H. MUSGRAVE
Research22 Oct 1971
Nature

Volume: 233, P: 538-541
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Polarity of structure and of ordered nerve connections in the developing amphibian brain

Shin-Ho Chung
Jonathan Cooke
Research13 Nov 1975
Nature

Volume: 258, P: 126-132
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein

An RNA-binding protein on leukemia cells provides an effective target in mouse models.

Benson M. George
Maria Eleftheriou
Konstantinos Tzelepis
ResearchOpen Access23 Apr 2025
Nature Biotechnology

P: 1-14
Woody cover and hominin environments in the past 6 million years

Thure E. Cerling
Jonathan G. Wynn
Christopher H. Remien
Research03 Aug 2011
Nature

Volume: 476, P: 51-56
Integrative multiplatform molecular profiling of benign prostatic hyperplasia identifies distinct subtypes

Benign prostatic hyperplasia (BPH) is one of the most common diseases affecting aging men with limited therapeutic options. In this study, the authors describe the molecular characterization of BPH performing genomic, transcriptomic and epigenetic analysis of 18 BPH cases.

Deli Liu
Jonathan E. Shoag
Christopher E. Barbieri
ResearchOpen Access24 Apr 2020
Nature Communications

Volume: 11, P: 1-9
Adaptive evolution of complex innovations through stepwise metabolic niche expansion

A fundamental question in evolutionary biology is how complex innovations requiring multiple genetic changes arise. Here the authors provide lines of evidence that changing environments facilitate the adaptive evolution of complex metabolic innovations via stepwise acquisition of single reactions.

Balázs Szappanos
Jonathan Fritzemeier
Balázs Papp
ResearchOpen Access20 May 2016
Nature Communications

Volume: 7, P: 1-10
Adversity and sex differences in social and emotional sensitivity in children; a possible mechanism for sex differences in psychiatric disorders

Jonathan Hill
Helen Sharp
Lynne Murray
ResearchOpen Access13 Sept 2010
Nature Precedings

P: 1
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

Jonathan Goldberg
Hsien-bin Huang
John Kuriyan
Research31 Aug 1995
Nature

Volume: 376, P: 745-753
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
A metric for spatially explicit contributions to science-based species targets

The species threat abatement and restoration (STAR) metric quantifies the contributions that abating threats and restoring habitats offer towards reducing species’ extinction risk in specific places.

Louise Mair
Leon A. Bennun
Philip J. K. McGowan
Research08 Apr 2021
Nature Ecology & Evolution

Volume: 5, P: 836-844
Reductions in commuting mobility correlate with geographic differences in SARS-CoV-2 prevalence in New York City

New York City is one of the areas most affected by the SARS-CoV-2 pandemic in the United States, and there has been large variation in rates of hospitalisation and death by city borough. Here, the authors show that boroughs with the largest reduction in daily commutes also had the lowest SARS-CoV-2 prevalence.

Stephen M. Kissler
Nishant Kishore
Yonatan H. Grad
ResearchOpen Access16 Sept 2020
Nature Communications

Volume: 11, P: 1-6
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice

A spatial transcriptomics and single-cell multiomics study performed on mouse brain tissue. Here, authors show region-specific spaceflight-induced alterations in processes of neurogenesis, synaptogenesis and synaptic transmission.

Yuvarani Masarapu
Egle Cekanaviciute
Stefania Giacomello
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-14
The formation of the Indo-Pacific montane avifauna

The mechanisms generating montane biodiversity remain incompletely understood. Here, the authors study the passerine avifauna of Indo-Pacific island mountains, finding that Eurasian-origin species colonized directly from other mountains, while Australo-Papuan-origin species made upslope range shifts from the lowlands.

Andrew Hart Reeve
Jonathan David Kennedy
Knud Andreas Jønsson
ResearchOpen Access11 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Dating the Late Archaic occupation of the Norte Chico region in Peru

Jonathan Haas
Winifred Creamer
Alvaro Ruiz
Research23 Dec 2004
Nature

Volume: 432, P: 1020-1023
The minimal work cost of information processing

Irreversible computation cannot be performed without a work cost, and energy dissipation imposes limitations on devices' performances. Here the authors show that the minimal work requirement of logical operations is given by the amount of discarded information, measured by entropy.

Philippe Faist
Frédéric Dupuis
Renato Renner
ResearchOpen Access07 Jul 2015
Nature Communications

Volume: 6, P: 1-8
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Periodic charge distributions in the myosin rod amino acid sequence match cross-bridge spacings in muscle

Andrew D. McLachlan
Jonathan Karn
Research16 Sept 1982
Nature

Volume: 299, P: 226-231
Why are concrete schools crumbling in the UK — and what can be done?

Researchers say safety concerns over RAAC concrete in UK schools could be “the tip of the iceberg”.

Jonathan O'Callaghan
News06 Sept 2023
Nature

Volume: 621, P: 242
Ocean current patterns drive the worldwide colonization of eelgrass (Zostera marina)

Ocean currents play a crucial role in the distribution of marine coastal species. Here the nuclear and chloroplast genomes of this eelgrass (Zostera marina L.) is used to trace its colonization history from its origin in the Northwest Pacific.

Lei Yu
Marina Khachaturyan
Thorsten B. H. Reusch
ResearchOpen Access20 Jul 2023
Nature Plants

Volume: 9, P: 1207-1220
Widespread Denisovan ancestry in Island Southeast Asia but no evidence of substantial super-archaic hominin admixture

A comprehensive search for super-archaic introgression in >400 modern human genomes, including >200 from Island Southeast Asia, corroborates widespread Denisovan ancestry in ISEA populations but fails to detect any substantial super-archaic admixture signals compatible with the endemic fossil record.

João C. Teixeira
Guy S. Jacobs
Kristofer M. Helgen
Research22 Mar 2021
Nature Ecology & Evolution

Volume: 5, P: 616-624
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Direct specification of lymphatic endothelium from mesenchymal progenitors

Lupu, Grainger, Kirschnick et al. show that, contrary to prevailing belief, the initial specification of mammalian lymphatic endothelial cells primarily occurs from previously unidentified mesenchymal angioblasts rather than from venous endothelium.

Irina-Elena Lupu
David E. Grainger
Oliver A. Stone
ResearchOpen Access02 Jan 2025
Nature Cardiovascular Research

Volume: 4, P: 45-63
Quantifying the energy and emissions implications of consumption redistribution in the UK through sustainable consumption corridors

Sam Betts-Davies
Anne Owen
Jonathan Norman
ResearchOpen Access12 May 2025
Scientific Reports

Volume: 15, P: 1-19
A tropical Volute shell and the Icarus syndrome

Jonathan C. Howard
News & Views09 Apr 1981
Nature

Volume: 290, P: 441-442
Self-care tooling innovation in a disabled kea (Nestor notabilis)

Amalia P. M. Bastos
Kata Horváth
Alex H. Taylor
ResearchOpen Access10 Sept 2021
Scientific Reports

Volume: 11, P: 1-8
Correction: Corrigendum: Germline hypomorphic CARD11 mutations in severe atopic disease

Chi A Ma
Jeffrey R Stinson
Joshua D Milner
Amendments and Corrections27 Oct 2017
Nature Genetics

Volume: 49, P: 1661
Modeling a primate technological niche

Jonathan S. Reeves
Tomos Proffitt
Lydia V. Luncz
ResearchOpen Access30 Nov 2021
Scientific Reports

Volume: 11, P: 1-9
Structural similarity between the p17 matrix protein of HIV-1 and interferon-γ

Stephen Matthews
Paul Barlow
Iain Campbell
Research25 Aug 1994
Nature

Volume: 370, P: 666-668
Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs

Alexander Yu. Rudensky
Paula Preston-Hurlburt,
Charles A. Janeway
Research01 Oct 1992
Nature

Volume: 359, P: 429-431
Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60^c-src

Shigeyuki Nada
Masato Okada
Hachiro Nakagawa
Research02 May 1991
Nature

Volume: 351, P: 69-72
Three glycolytic enzymes are phosphorylated at tyrosine in cells transformed by Rous sarcoma virus

Jonathan A. Cooper
Nachum A. Reiss
Tony Hunter
Research17 Mar 1983
Nature

Volume: 302, P: 218-223
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer

Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating T cell fraction provides sex-dependent and prognostic insights in patients.

Robert Bentham
Thomas P. Jones
Nicholas McGranahan
ResearchOpen Access18 Feb 2025
Nature Genetics

Volume: 57, P: 694-705
Proper names for early fingers

Jonathan Cooke
News & Views06 Sept 1990
Nature

Volume: 347, P: 14-15

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