Nature Search

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Genome-wide association analyses identify 30 risk loci for IgA nephropathy. Functional annotations of putative causal genes converge on inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.

Krzysztof Kiryluk
Elena Sanchez-Rodriguez
Ali G. Gharavi
Research19 Jun 2023
Nature Genetics

Volume: 55, P: 1091-1105
Widespread potential for streamflow leakage across Brazil

Most Brazilian rivers are found to have the potential for stream water losses into underlying aquifers, especially in drier climates, thicker aquifers, and regions with extensive groundwater pumping.

José Gescilam S. M. Uchôa
Paulo Tarso S. Oliveira
Edson C. Wendland
ResearchOpen Access25 Nov 2024
Nature Communications

Volume: 15, P: 1-11
The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis

Membranous nephropathy (MN) is a rare autoimmune disease of podocyte-directed antibodies, such as anti-phospholipase A2 receptor. Here, the authors report a genome-wide association study for MN and identify two previously unreported loci encompassing the NFKB1 and IRF4 genes and additional ancestry-specific effects.

Jingyuan Xie
Lili Liu
Krzysztof Kiryluk
ResearchOpen Access30 Mar 2020
Nature Communications

Volume: 11, P: 1-18
The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics

Ann M. Mc Cartney
Giulio Formenti
Camila J. Mazzoni
ResearchOpen Access17 Sept 2024
npj Biodiversity

Volume: 3, P: 1-17
Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population

Zuray Corredor
Miguel Inácio da Silva Filho
Susana Pastor
ResearchOpen Access10 Jan 2020
Scientific Reports

Volume: 10, P: 1-11
Targeted next-generation sequencing in steroid-resistant nephrotic syndrome: mutations in multiple glomerular genes may influence disease severity

Gemma Bullich
Daniel Trujillano
Elisabet Ars
Research19 Nov 2014
European Journal of Human Genetics

Volume: 23, P: 1192-1199

Quick links

Search

Filter By:

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Widespread potential for streamflow leakage across Brazil

The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis

The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics

Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population

Targeted next-generation sequencing in steroid-resistant nephrotic syndrome: mutations in multiple glomerular genes may influence disease severity

Search

Quick links