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Showing 1–5 of 5 results
Advanced filters: Author: Joshua M. Chevalier Clear advanced filters

  • While BH3-mimetics can be effective for treatment of haematological malignancies, their efficacy in solid tumours is limited. Here, using a range of patient-derived prostate cancer models, the authors demonstrate that increased replication stress induced by RB1 loss confers sensitivity to BH3 mimetics targeting BCL-XL.

    • Andreas Varkaris
    • Keshan Wang
    • Steven P. Balk
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • The extent, origins and consequences of genetic variation within human cell lines are studied, providing a framework for researchers to measure such variation in efforts to support maximally reproducible cancer research.

    • Uri Ben-David
    • Benjamin Siranosian
    • Todd R. Golub
    Research
    Nature
    Volume: 560, P: 325-330

  • In individuals who have achieved natural control of HIV-1 without drug treatment, intact proviral sequences are integrated into genomic regions that are not permissive to active viral transcription, indicating deep latency of the virus.

    • Chenyang Jiang
    • Xiaodong Lian
    • Xu G. Yu
    Research
    Nature
    Volume: 585, P: 261-267

  • The dynamics of HIV-1 DNA sequences early after HIV-1 transmission remains poorly characterized. Here, the authors perform a longitudinal evaluation of HIV-1 DNA sequences in subtype C-infected individuals during acute infection, providing a landscape of the nature and evolution of the very early viral genome.

    • Guinevere Q. Lee
    • Kavidha Reddy
    • Mathias Lichterfeld
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11