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Showing 1–3 of 3 results
Advanced filters: Author: Juan Pablo Arcon Clear advanced filters

  • Multi-layered epigenetic regulation in higher eukaryotes makes it challenging to disentangle the individual effects of modifications on chromatin structure and function. Here, the authors expressed mammalian DNA methyltransferases in yeast, which have no DNA methylation, to show that methylation has intrinsic effects on chromatin structure.

    • Diana Buitrago
    • Mireia Labrador
    • Modesto Orozco
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Basu and colleagues comprehensively characterize how sequence and epigenetic modifications impact the local mechanical properties of DNA. The results suggest that DNA mechanics may have evolved to aid diverse DNA-deforming biological processes.

    • Aakash Basu
    • Dmitriy G. Bobrovnikov
    • Taekjip Ha
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 1178-1187