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Tailored non-aqueous electrolyte solutions are formulated using data obtained from extensive analytical measurements and analyses. These optimized electrolytes improve the cycling performance of single-layer stack lithium metal pouch cells, particularly in lean electrolyte conditions.

Frost is typically seen as a threat to plants and is expected to lead to decreased ecosystem carbon uptake due to reduced photosynthesis. However, this research shows that spring frosts can actually enhance ecosystem carbon absorption, while autumn frosts behave as expected, prompting an increase in carbon emissions.

Rechargeable lithium batteries featuring 5 V cathodes offer high energy density yet struggle with stability. Here, the authors formulate an electrolyte incorporating dimethyl 2,5-dioxahexanedioate solvent, which facilitates stable lithium plating and stripping while offering an extended cycle life.

Ductal lavage represents a treatment option for idiopathic granulomatous mastitis. Here, the authors report the results of a randomized clinical trial, indicating that ductal lavage followed by observation is non-inferior to oral corticosteroids

Transient R-loops form around DSBs must be timely removed for HR repair. Here, the authors show that SART3 promotes DDX1 helicase binding to DSBs for optimal DNA-RNA hybrid removal, and enhances USP15-BARD1 association for efficient DNA end resection.

Spur-type of growth is preferred for apple production. Here, the authors employ the trio-based phasing approach to assemble a fully phased Fuji genome and reveal the association of a 167-bp deletion in the promoter region of the MdTCP11 gene with the spur-type varieties.

Jing Wang, Fengchun Zhang and colleagues report the results of a genome-wide association study of primary Sjögren's syndrome, a common autoimmune disease. They confirm associations in the STAT4, TNFAIP3 and HLA regions and identify a new susceptibility locus in the GTF2I region at 7q11.23.

The development of nanocarriers for targeted protein delivery requires methods for high-throughput screening in vitro and in vivo. Here authors develop a DNA-barcoded method to identify nanocarriers with different biodistributions, and demonstrate delivery of catalase to the kidneys of female mice, successfully mitigating cisplatin-induced acute kidney injury.

T follicular helper (T_FH) cells are specialized effector CD4⁺ T cells that are critical in humoral immunity, but the function of post-transcriptional regulation is not clearly defined. Here, the authors demonstrate that RNA methylation is important for T_FH effector differentiation and subsequent antibody formation through stabilization of Tcf7 transcripts.

Manipulating the internal interactions within biological fibers to tune macroscopic properties is important but challenging, and can limit applications. Here, the authors report the use of dynamic imine chemistry for engineering molecular interactions and forming strong and tough protein fibers.

A membrane-tethering liquid–liquid phase-separation system was developed for programmable compartmentalization of cell-surface proteins and regulation of downstream cellular activities.

The mechanisms underlying differential chemotherapeutic response to 5-fluorouracil are not fully known. Here, the authors show that ABDH5 regulates sensitivity to 5-fluorouracil in colorectal cancer by regulating lysosome function.

Inflammasomes are multiprotein complexes, including the protein ASC, that assemble in response to inflammatory stimulation. Here the authors characterise the regulation of ASC during inflammasome formation and show the involvement of SUMOylation and zinc-finger and BTB ___domain-containing protein 16 (ZBTB16).

Tumour cells can communicate with cells from distant organs through extracellular vesicles. Here the authors show that breast cancer cells derived exosomal miR-204-5p induce leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia.

The role of PHD finger protein 8 (PHF8) in anti-tumour immunity remains to be investigated. Here, the authors suggest PHF8 as an epigenetic checkpoint and show that targeting PHF8 induces a viral mimicry response enhancing anti-tumour immunity in colorectal cancer.

Whether the female reproductive tract harbours distinct microbiomes beyond the vagina has been a matter of debate. Here, the authors show a subject-specific continuity in microbial communities at six sites along the female reproductive tract, indicative of a non-sterile environment.

Here, the authors combine structural, binding, mutational in vitro and in vivo assays to characterize neutralizing antibodies derived from IGHV3-53/3-66 against SARS-CoV-2, finding one antibody, named P5A-3C8, to exhibit protective efficacy in a golden Syrian hamster model of infection while showing the emergence of mutations at position 417 of the Spike protein that confer resistance.

The off-target effects of any CRISPR-based genome editor are identified with Tracking-seq.

Disrupting the interaction between telomere protein TRF1 with meiosis-specific protein TERB1 impairs the pairing of X and Y chromosomes via their telomere-adjacent pseudoautosomal regions in pachytene, leading to spermatocyte apoptosis and male infertility in mice.

Using data-driven epidemiological modelling, Yu et al. estimate that, even with increasing vaccine availability, China will have to maintain stringent non-pharmaceutical interventions for at least a year to prevent new widespread outbreaks of COVID-19.

ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBP_ɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production.

Two or more enzymes encapsulated in a thin polymer shell can lower blood alcohol levels in intoxicated mice, offering a way to prevent liver injury arising from the overconsumption of alcohol.

Mulberry trees are the primary food source for silkworms, which are reared for the production of silk. In this study, He et al. present the draft genome sequence of Morus notabilisand find that it evolved significantly faster than other plants in the Rosales order.

Combined RNA-seq and CHIP-seq analysis revealed the regulatory mechanism of ArgR in bacterial motility of Aeromonas veronii.

Fe-based electrodes emerge as an effective and economical option to treat nitrate-laden wastewater. Whereas Fe cathode corrosion is commonly considered as an adverse factor for the electroreduction of nitrate to ammonia, intentional corrosion-induced surficial reconstruction has the potential to enhance catalytic performance.

This study reveals an unrecognized role of ABHD5 in regulating colon cancer stemness via controlling YAP methylation and nuclear localization, further explaining the molecular mechanism through which ABHD5 functions as a tumour suppressor gene in colon cancer.

Sustained cardiac function depends on circadian REV-ERBs. Here, Dierickx et al. show that circadian nuclear receptors REV-ERBα and β are indispensable to establish the transcriptional program that controls cardiac metabolism and NAD⁺ production. Deregulation of REV-ERBs leads to dilated cardiomyopathy and premature death.

The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

The TERB1-TERB2-MAJIN complex mediates the attachment of telomeres to the nuclear envelope. Here the authors present the crystal structures of the human TERB1-TERB2 and TERB2-MAJIN subcomplexes and show that Terb2 mutations, which abolish complex formation cause aberrant homologous pairing and disordered synapsis in mouse.