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Tailored non-aqueous electrolyte solutions are formulated using data obtained from extensive analytical measurements and analyses. These optimized electrolytes improve the cycling performance of single-layer stack lithium metal pouch cells, particularly in lean electrolyte conditions.

The crosstalk between bile acid (BA) metabolism and the Hippo pathway plays a role in pathogenesis of liver diseases. Here the authors show that the transcriptional coactivator YAP exerts a repressor role on Farnesoid X receptor (Fxr), the master transcriptional regulator of BA synthesis, contributing to the development of hepatocellular carcinoma.

Spur-type of growth is preferred for apple production. Here, the authors employ the trio-based phasing approach to assemble a fully phased Fuji genome and reveal the association of a 167-bp deletion in the promoter region of the MdTCP11 gene with the spur-type varieties.

Ductal lavage represents a treatment option for idiopathic granulomatous mastitis. Here, the authors report the results of a randomized clinical trial, indicating that ductal lavage followed by observation is non-inferior to oral corticosteroids

T follicular helper (T_FH) cells are specialized effector CD4⁺ T cells that are critical in humoral immunity, but the function of post-transcriptional regulation is not clearly defined. Here, the authors demonstrate that RNA methylation is important for T_FH effector differentiation and subsequent antibody formation through stabilization of Tcf7 transcripts.

In a study of antibodies isolated from patients infected with SARS-CoV-2, antibodies that potently neutralized the virus competed with angiotensin-converting enzyme 2 for binding to the receptor-binding ___domain of the viral spike protein, suggesting that antibodies that disrupt this interaction could be developed to treat SARS-CoV-2 infection.

The development of nanocarriers for targeted protein delivery requires methods for high-throughput screening in vitro and in vivo. Here authors develop a DNA-barcoded method to identify nanocarriers with different biodistributions, and demonstrate delivery of catalase to the kidneys of female mice, successfully mitigating cisplatin-induced acute kidney injury.

This study reveals a pathway in which the transformation of trifoliate leaves into pinnate-like pentafoliate leaves is regulated by the conserved regulators of floral development (MtUFO) and leaf development (MtKNOXI) in M. truncatula.

Reactive school class closures have been widely implemented to mitigate COVID-19 outbreaks. Here, the authors show that, compared to symptom-prompted PCR testing, screening for cases in schools with antigen tests leads to greater reductions in infection rates in both students and the wider community.

Using data-driven epidemiological modelling, Yu et al. estimate that, even with increasing vaccine availability, China will have to maintain stringent non-pharmaceutical interventions for at least a year to prevent new widespread outbreaks of COVID-19.

Genome-wide association studies in Chinese and Europeans have identified multiple loci associated with congenital heart disease. Here the authors use existing GWAS data to conduct an extended three-stage analysis in Han Chinese and identify four novel loci linked to disease risk in this population.

The off-target effects of any CRISPR-based genome editor are identified with Tracking-seq.

Whether the female reproductive tract harbours distinct microbiomes beyond the vagina has been a matter of debate. Here, the authors show a subject-specific continuity in microbial communities at six sites along the female reproductive tract, indicative of a non-sterile environment.

ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBP_ɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production.

Structure determination followed by targeted engineering of the popular photoactivatable fluorescent protein monomeric (m)Eos2 yields mEos3 versions that are more monomeric and less disruptive in protein fusions and also exhibit higher labeling density, brightness and other beneficial properties.

Disrupting the interaction between telomere protein TRF1 with meiosis-specific protein TERB1 impairs the pairing of X and Y chromosomes via their telomere-adjacent pseudoautosomal regions in pachytene, leading to spermatocyte apoptosis and male infertility in mice.

Here, the authors combine structural, binding, mutational in vitro and in vivo assays to characterize neutralizing antibodies derived from IGHV3-53/3-66 against SARS-CoV-2, finding one antibody, named P5A-3C8, to exhibit protective efficacy in a golden Syrian hamster model of infection while showing the emergence of mutations at position 417 of the Spike protein that confer resistance.

In the context of limited supply, strategies for optimising allocation of COVID-19 vaccines are needed. Here, the authors explore time-varying strategies that adapt to the epidemiological situation and simultaneously optimise for multiple objectives including reducing numbers of infections, hospitalisations, and deaths.

Rechargeable lithium batteries featuring 5 V cathodes offer high energy density yet struggle with stability. Here, the authors formulate an electrolyte incorporating dimethyl 2,5-dioxahexanedioate solvent, which facilitates stable lithium plating and stripping while offering an extended cycle life.

This study reveals an unrecognized role of ABHD5 in regulating colon cancer stemness via controlling YAP methylation and nuclear localization, further explaining the molecular mechanism through which ABHD5 functions as a tumour suppressor gene in colon cancer.

Mulberry trees are the primary food source for silkworms, which are reared for the production of silk. In this study, He et al. present the draft genome sequence of Morus notabilisand find that it evolved significantly faster than other plants in the Rosales order.

The TERB1-TERB2-MAJIN complex mediates the attachment of telomeres to the nuclear envelope. Here the authors present the crystal structures of the human TERB1-TERB2 and TERB2-MAJIN subcomplexes and show that Terb2 mutations, which abolish complex formation cause aberrant homologous pairing and disordered synapsis in mouse.

The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

Radial-velocity measurements of a Galactic B-type star show a dark companion that seems to be a black hole of about 68 solar masses, in a widely spaced binary system.

A population of partially exhausted CXCR5⁺ CD8⁺ T cells, induced by chronic virus infection and residing in B-cell follicles, is shown to control viral replication.