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Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cervical screening is a key method for detecting cervical cancer, but is limited by pathologist detection. Here, the authors use artificial intelligence to predict cytology grades from whole slide images.

Propane dehydrogenation is an important reaction for the production of propylene, although effective catalysts are generally constructed from precious metals. Here, the authors report a high-performing earth-abundant alternative system for this reaction based on a particular form of cobalt on siliceous zeolites.

Ultrasound particle image velocimetry (uPIV) is widely used for blood flow measurement but is limited by the diffraction limit. Jingyi Yin, Jiabin Zhang, Jue Zhang and colleagues propose enhanced ultrasound particle image velocimetry (EuPIV), which enables dynamic microflow imaging with higher spatial resolution.

The authors present a FeCl₃ cathode design that enables all-solid-state lithium-ion batteries with a favourable combination of low cost, improved safety and good performance.

Multidrug resistance-associated protein 2 (MRP2) is an ATP-powered multidrug exporter. Here, authors present the structure of MRP2 in three functional states, revealing how ATP hydrolysis is coupled to substrate secretion and how the R ___domain regulates transport activity.

Lightweight, flexible and strong fibre actuators that respond to solvents and vapours are made by twisting together several well-aligned helical fibres of multiwalled carbon nanotubes.

In the layered magnetic semiconductor CrSBr, excitons can strongly couple to nonlinear magnons. This coupling enables tunable magnon frequency mixing, parametric amplification and excitons dressed with up to 20 harmonics of magnons.

Products from ultracold atom–dimer exothermic reactions can be directly observed by controlling the energy released during the process, bringing the study of chemical dynamics to the quantum level.

By using scanning tunnelling microscopy and spectroscopy, researchers observe layer-dependent electronic correlations in rhombohedral graphene multilayers at 77 K, revealing the layer-enhanced low-energy flat bands and interlayer interactions.

Lymph node (LN) metastases after primary treatment may end up with disease recurrence and poor survival rate. Here this group designs a phospholipase A₂ (sPLA₂)-responsive nanosystem delivering doxorubicin for in vivo inhibition of both primary colorectal tumor progression and LN metastasis.

This new β-Li₃N solid-state electrolyte demonstrates a vacancy-mediated superionic diffusion mechanism, achieving high ionic conductivity (2.14 × 10⁻³ S cm⁻¹) and effectively suppressing lithium dendrite growth. Its high compatibility with lithium and air stability promises improved safety and performance in all-solid-state lithium metal batteries, making it ideal for advanced energy storage applications.

A pH-responsive DNA origami device displays a precise geometric array of CD95 ligands to selectively induce activated immune cell death and elicit localized immune tolerance to alleviate rheumatoid arthritis.

Differently from Arabidopsis, rice UV-B photoreceptors show a non-classical localization mechanism and protein interaction mode to mediate UV-B responses, suggestive of evolutionary divergence of UV-B light signaling between monocot and dicot plants.

While solid-state lithium-ion batteries offer promising energy densities for safe energy storage, typical solid electrolytes show poor room-temperature ionic conduction. Now the origin of the superionic transition observed in Li₃YCl₆-type Li-ion conductors is revealed by in-depth crystal structure characterizations and improved ionic conductivities achieved by lowering the transition temperature.

Comprehensive profiles of tumour and microenvironment are critical to understand heterogeneity in non-small cell lung cancer (NSCLC). Here, the authors profile 42 late-stage NSCLC patients with single-cell RNA-seq, revealing immune landscapes that are associated with cancer subtype or heterogeneity.

Most genetic studies for prostate cancer have been performed outside the context of Sub-Saharan Africa. Here, the authors interrogate 247,780 exomic variants for 798 Black South African men and identify genes associated with aggressive disease.

Existing methods for detecting transposable elements (TEs) in genome assemblies have limited accuracy and robustness, and the results often require extensive manual editing. Here, the authors present a fast and accurate dynamic boundary adjustment approach that improves detection and annotation of full-length TEs across various species.

Cancer cells downregulate surface expression of major histocompatibility complex I (MHC-I) for immune evasion. Here, the authors show that rapid mitochondrial fission activates the ER-stress response leading to reduced MHC-I complex formation and cell surface expression in solid cancer cells; moreover inhibition of mitochondrial fission increases the immune-mediated anticancer response in murine models.

A three-photon miniature microscope with optimized light-collection efficiency facilitates imaging of neuronal activity throughout the cortex, as well as in the hippocampus, in freely moving mice.

Here, the authors develop an AAV-CRISPR mediated somatic knock-in. They apply this system to restore hemostasis in neonatal hemophilia B mice and show liver-specificity of the knock-in and low serum antibody production.

Pacific Biosciences (PacBio) High Fidelity (HiFi) long-read sequencing usually requires a relatively high amount of DNA input ( > 1 µg). Here the authors develop LILAP, a Low-Input (100 ng), Low-cost, and Amplification-free library-generation method for PacBio sequencing, enabling the generation of two high-quality individual fly genomes.

NUP98–IQCG is a fusion protein found in acute leukaemia that functions as a regulator of transcriptional expression. Here, Chen et al. investigate IQCG-mediated calcium signalling in haematopoiesis, and propose a model where IQCG can store calmodulin, which once released, activates CaM-dependent kinase IV.

The cryo-electron microscopy structure of human TAP transporter, a peptide transporter central to MHC class I antigen presentation and cellular immunity, in complex with the herpes simplex virus protein ICP47.

Immune checkpoint inhibition is a successful form of immune therapy; however response rates vary widely among individual patients. Here authors show that circulating small extracellular vesicles might contribute to poor response to anti-PD-1 treatment by carrying PD-1 and CD80 which results in higher level of vesicular PD-L1 expression in the circulation at the expense of expression on tumour cell membranes, causing immunosuppression.

A study shows that implants with an adhesive implant–tissue interface mitigate the formation of a fibrous capsule when attached to various organs in mice, rats and pigs.

A graphene nanocomposite hydrogel showing anisotropic swelling is used to realize an electrically conducting and removable bioadhesive that improves the mechanical and electrical integration of bioelectronics devices with wet dynamic tissues.

Biochemical and structural analysis of the drug transporter P-glycoprotein in Caenorhabditis elegans at a resolution of 3.4 angstroms is used to generate a homology model of the human protein and supports a picture in which P-glycoprotein uses the energy from ATP hydrolysis to expel lipophilic molecules from the inner leaflet of the cell membrane.

Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

Which combination of current genome sequencing and assembly approaches results in high-quality, complete diploid genome assemblies is determined.

The formation of electrochemically inactive, or “dead”, lithium limits the reversibility of lithium metal batteries. Here the authors elucidate the (electro)chemical roles of ethylene gas produced from electrolyte decomposition on the formation of inactive lithium.

Here, the authors use single-molecule long-read sequencing to decipher the role of structural variations in high-altitude adaptation, finding evidence that an intergenic deletion down-regulates EPAS1 by disrupting a super-enhancer.

Raised serum urate levels are a risk factor for gout, a common form of inflammatory arthritis. Here Li et al.conduct a multistage genome-wide association study in a Han Chinese population and identify three novel loci likely associated with the progression from hyperuricemia to gout.

Primary dysmenorrhoea, the most common gynaecologic complaint, remains genetically and pathophysiologically elusive. Here, Li and colleagues identify common variants inZMIZ1 and near NGFconferring risk for primary dysmenorrhoea using genome-wide association study in a Chinese population.

The novoBreak software provides sensitive, accurate, and comprehensive detection of structural variation in somatic next-generation sequencing data.

The Kondo effect usually refers to increased electrical resistance in metals due to spin-spin interactions between localized magnetic impurities and conduction electrons. Here the authors report a Kondo-like coupling between a light-induced exciton and localized impurity spins in Nd-doped hybrid perovskite.

Castor is an important industrial oil crop, but knowledge on its genetic diversity is limited. Here, Fan et al. show geographic pattern of Chinese castors that have developed during domestication by population genetic analyses, and reveal candidate genes associated with agronomically important traits.

A genome-wide association analysis using data from Chinese individuals combined with a transethnic meta-analysis of Psychiatry Genomics Consortium data identifies 30 new loci for schizophrenia. These analyses improve the fine-mapping of susceptibility loci and implicate multiple pathways in schizophrenia biology.