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A neoantigen vaccine generates antitumour immunity in renal cell carcinoma

A phase I trial of a neoantigen-targeting personalized cancer vaccine led to durable and polyfunctional T cell responses and antitumour recognition, and was associated with no recurrence in patients with high-risk clear cell renal cell carcinoma.

David A. Braun
Giorgia Moranzoni
Toni K. Choueiri
ResearchOpen Access05 Feb 2025
Nature

Volume: 639, P: 474-482
Patterns of referrals to regional clinical genetics services for women potentially at above-population level risk of breast cancer

Juliet A. Usher-Smith
Georgia Tooth
Marc Tischkowitz
ResearchOpen Access11 Jan 2024
BJC Reports

Volume: 2, P: 1-7
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma

Sarcomatoid and rhabdoid tumours are highly aggressive forms of renal cell carcinoma that are also responsive to immunotherapy. In this study, the authors perform a comprehensive molecular characterization of these tumours discovering an enrichment of specific alterations and an inflamed phenotype.

Ziad Bakouny
David A. Braun
Toni K. Choueiri
ResearchOpen Access05 Feb 2021
Nature Communications

Volume: 12, P: 1-14
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma

A pooled genetic, transcriptomic and immunopathologic analysis of over 500 tumors from patients with advanced renal cell cancer suggests that response to PD-1 blockade depends on both CD8⁺ T cell infiltration and enrichment of tumor-intrinsic somatic alterations.

David A. Braun
Yue Hou
Toni K. Choueiri
Research29 May 2020
Nature Medicine

Volume: 26, P: 909-918
Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma

Personalized neoantigen vaccination in patients with melanoma elicits durable and specific memory T cell clones that have cytotoxic gene signatures and can diversify to include nonvaccine neoantigen specificities.

Zhuting Hu
Donna E. Leet
Patrick A. Ott
Research21 Jan 2021
Nature Medicine

Volume: 27, P: 515-525
Phenotype, specificity and avidity of antitumour CD8⁺ T cells in melanoma

The authors use single-cell profiling and T cell receptor specificity screening to show how tumour antigen recognition shapes the phenotypes of CD8⁺ T cells and antitumour immune responses.

Giacomo Oliveira
Kari Stromhaug
Catherine J. Wu
Research21 Jul 2021
Nature

Volume: 596, P: 119-125
Author Correction: Assembly of a pan-genome from deep sequencing of 910 humans of African descent

Rachel M. Sherman
Juliet Forman
Steven L. Salzberg
Amendments and Corrections15 Jan 2019
Nature Genetics

Volume: 51, P: 364
Assembly of a pan-genome from deep sequencing of 910 humans of African descent

Assembly of a pan-genome from 910 humans of African descent identifies 296.5 Mb of novel DNA mapping to 125,715 distinct contigs. This African pan-genome contains ~10% more DNA than the current human reference genome.

Rachel M. Sherman
Juliet Forman
Steven L. Salzberg
ResearchOpen Access19 Nov 2018
Nature Genetics

Volume: 51, P: 30-35
RNase H–dependent PCR-enabled T-cell receptor sequencing for highly specific and efficient targeted sequencing of T-cell receptor mRNA for single-cell and repertoire analysis

Here, the authors describe rhTCRseq, RNase H–dependent PCR-enabled TCR sequencing, for repertoire analysis from bulk RNA samples or single-cell profiling.

Shuqiang Li
Jing Sun
Kenneth J. Livak
Protocols24 Jul 2019
Nature Protocols

Volume: 14, P: 2571-2594

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