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Bacteria-based cancer immunotherapeutics and radiotheranostics

Immunotherapies often fail due to limited response rates or acquired resistance. CNCure Biotech is poised to overcome these problems with a novel bacterial platform to develop treatments for oncology and infectious diseases.

CNCure Biotech
Advertorial29 Nov 2024
Biopharma Dealmakers
Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella

Cancer immunotherapeutic agents can be tumour-targeted to improve their therapeutic efficacy. Here the authors engineer Salmonella typhimurium loaded with cytolysin A and flagellin B to potentiate its anti-tumour activity in primary and metastatic tumours.

Dinh-Huy Nguyen
Sung-Hwan You
Jung-Joon Min
ResearchOpen Access06 Aug 2024
Nature Communications

Volume: 15, P: 1-17
Mucosal TLR5 activation controls healthspan and longevity

Understanding how the immune system’s functionality declines with age is crucial for addressing aging-related health issues. Here, the authors demonstrate that activating TLR5 in the mucosal layer can significantly improve healthspan and longevity, suggesting a novel approach for aging interventions.

Jae Sung Lim
Eun Jae Jeon
Kyung A Cho
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-14
Author Correction: Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella

Dinh-Huy Nguyen
Sung-Hwan You
Jung-Joon Min
Amendments and CorrectionsOpen Access27 Jan 2025
Nature Communications

Volume: 16, P: 1
In vivo imaging of invasive aspergillosis with ¹⁸F-fluorodeoxysorbitol positron emission tomography

Current diagnostic methods for invasive aspergillosis are time-consuming and poorly sensitive. Here, the authors show that positron emission tomography with 2-deoxy-2-¹⁸F-fluorosorbitol can visualize Aspergillus fumigatus infection of the lungs, brain and muscles in mouse models, and can distinguish pulmonary aspergillosis from other diseases such as Staphylococcus aureus infection and lung cancer.

Dong-Yeon Kim
Ayoung Pyo
Jung-Joon Min
ResearchOpen Access08 Apr 2022
Nature Communications

Volume: 13, P: 1-11
Distinctive patterns of peripheral neuropathy across the spectrum of plasma cell disorders

Ja Min Byun
Young Nam Kwon
Inho Kim
ResearchOpen Access14 Nov 2019
Scientific Reports

Volume: 9, P: 1-7
Optical coherence tomography-based machine learning for predicting fractional flow reserve in intermediate coronary stenosis: a feasibility study

Jung-Joon Cha
Tran Dinh Son
Yangsoo Jang
ResearchOpen Access24 Nov 2020
Scientific Reports

Volume: 10, P: 1-8
The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages

The effects of iron on vacuole-resident Salmonella in macrophages are unclear. Here the authors show that the bacteria are not subject to nutritional inhibition by iron deprivation, but that iron depletion in the vacuole, via the hepcidin-ferroportin axis, inhibits the bactericidal effect of oxidative burst.

Daejin Lim
Kwang Soo Kim
Hyon E. Choy
ResearchOpen Access29 May 2018
Nature Communications

Volume: 9, P: 1-12
Cerebral small vessel disease as imaging biomarker predicting ocular cranial nerve palsy of presumed ischemic origin at admission

Dong-Wan Kang
Sue Young Ha
Hyunwoo Nam
ResearchOpen Access18 Jul 2022
Scientific Reports

Volume: 12, P: 1-9
GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in neuronal systems, but the potential role for such neurotransmitters on the immune system are emerging. Here the authors show GABA signaling is linked to autophagy, enhancing the host response against intracellular bacteria.

Jin Kyung Kim
Yi Sak Kim
Eun-Kyeong Jo
ResearchOpen Access10 Oct 2018
Nature Communications

Volume: 9, P: 1-17
Quantitative bioluminescence imaging of tumor-targeting bacteria in living animals

Jung-Joon Min
Vu H Nguyen
Hyon E Choy
Protocols20 Mar 2008
Nature Protocols

Volume: 3, P: 629-636
Reporter gene-based optoacoustic imaging of E. coli targeted colon cancer in vivo

Misun Yun
Sung-Hwan You
Vasilis Ntziachristos
ResearchOpen Access24 Dec 2021
Scientific Reports

Volume: 11, P: 1-9
Dissociated leg muscle atrophy in amyotrophic lateral sclerosis/motor neuron disease: the ‘split-leg’ sign

Young Gi Min
Seok-Jin Choi
Jung-Joon Sung
ResearchOpen Access24 Sept 2020
Scientific Reports

Volume: 10, P: 1-8
Small RNA sequencing of circulating small extracellular vesicles microRNAs in patients with amyotrophic lateral sclerosis

Jin-Ah Kim
Canaria Park
Yoon-Ho Hong
ResearchOpen Access04 Apr 2023
Scientific Reports

Volume: 13, P: 1-9
High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis

Seok-Jin Choi
Yoon-Ho Hong
Jung-Joon Sung
ResearchOpen Access16 Jan 2020
Scientific Reports

Volume: 10, P: 1-6
Bioengineering of bacteria for cancer immunotherapy

Here, we provide a brief overview of the approaches and strategies underlying bacteria-based cancer immunotherapy (BCiT). We also describe and summarize research in the field of synthetic biology, which aims to regulate bacterial growth and gene expression for immunotherapeutic use. Finally, we discuss the current clinical status and limitations of BCiT.

Dinh-Huy Nguyen
Ari Chong
Jung-Joon Min
Comments & OpinionOpen Access15 Jun 2023
Nature Communications

Volume: 14, P: 1-5
Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis

Mammals respond to bacterial infection by inducing the expression of hepcidin, which restricts serum iron levels through its effects on macrophage iron export and thereby limits systemic bacterial growth. Kim et al. now report that the macrophage-tropic pathogen Salmonella typhimurium exploits this pathway by triggering the expression of estrogen-related receptor-γ (ERR-γ), which they show increases hepcidin expression and enhances S. typhimurium growth.

Don-Kyu Kim
Jae-Ho Jeong
Hueng-Sik Choi
Research23 Mar 2014
Nature Medicine

Volume: 20, P: 419-424
Exploiting bacteria for cancer immunotherapy

Increasing evidence indicates that intratumoural bacteria can have crucial roles in both the pathogenesis and treatment of cancer. In this Review, the authors discuss the characteristics of intratumoural bacteria and the emerging understanding of their tumour-promoting and antitumour activities. They also describe a range of innovative strategies that are being used to engineer bacteria for use in the treatment of cancer and summarize clinical trials of various bacteria-mediated cancer immunotherapies.

Seong-Young Kwon
Hien Thi-Thu Ngo
Jung-Joon Min
Reviews05 Jun 2024
Nature Reviews Clinical Oncology

Volume: 21, P: 569-589
Bacteria-cancer interactions: bacteria-based cancer therapy

Mai Thi-Quynh Duong
Yeshan Qin
Jung-Joon Min
ReviewsOpen Access11 Dec 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-15
Enhanced resolution and sensitivity acoustic-resolution photoacoustic microscopy with semi/unsupervised GANs

Thanh Dat Le
Jung-Joon Min
Changho Lee
ResearchOpen Access17 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and ¹⁸F-FDG PET/CT

Hee Jeong Cho
Sung-Hoon Jung
Joon Ho Moon
ResearchOpen Access01 Dec 2021
Blood Cancer Journal

Volume: 11, P: 1-8
Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase

Byung-Hee Chung
Sookon Kim
Young-Myeong Kim
ResearchOpen Access14 Dec 2011
Experimental & Molecular Medicine

Volume: 44, P: 191-201
New paradigm for tumor theranostic methodology using bacteria-based microrobot

Sung Jun Park
Seung-Hwan Park
Sukho Park
ResearchOpen Access02 Dec 2013
Scientific Reports

Volume: 3, P: 1-8
Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines

Tae Hyeon Koo
Jung-Joon Lee
Jeong-Hyung Lee
Research05 Jun 2002
Oncogene

Volume: 21, P: 4080-4088
High platelet reactivity strongly predicts early stent thrombosis in patients with drug-eluting stent implantation

Subin Lim
Soon Jun Hong
Myung Ho Jeong
ResearchOpen Access04 Jan 2024
Scientific Reports

Volume: 14, P: 1-11
Association of muscle and visceral adipose tissues with the probability of Alzheimer’s disease in healthy subjects

Jahae Kim
Kang-Ho Choi
Ho-Chun Song
ResearchOpen Access30 Jan 2019
Scientific Reports

Volume: 9, P: 1-8
Enhancement of antitumor effect using dendritic cells activated with natural killer cells in the presence of Toll-like receptor agonist

Thanh Nhan Nguyen Pham
Cheol Yi Hong
Je-Jung Lee
ResearchOpen Access13 Apr 2010
Experimental & Molecular Medicine

Volume: 42, P: 407-419

Search

Bacteria-based cancer immunotherapeutics and radiotheranostics

Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella

Mucosal TLR5 activation controls healthspan and longevity

Author Correction: Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella

In vivo imaging of invasive aspergillosis with ¹⁸F-fluorodeoxysorbitol positron emission tomography

Distinctive patterns of peripheral neuropathy across the spectrum of plasma cell disorders

Optical coherence tomography-based machine learning for predicting fractional flow reserve in intermediate coronary stenosis: a feasibility study

The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages

Cerebral small vessel disease as imaging biomarker predicting ocular cranial nerve palsy of presumed ischemic origin at admission

GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections

Quantitative bioluminescence imaging of tumor-targeting bacteria in living animals

Reporter gene-based optoacoustic imaging of E. coli targeted colon cancer in vivo

Dissociated leg muscle atrophy in amyotrophic lateral sclerosis/motor neuron disease: the ‘split-leg’ sign

Small RNA sequencing of circulating small extracellular vesicles microRNAs in patients with amyotrophic lateral sclerosis

High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis

Bioengineering of bacteria for cancer immunotherapy

Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis

Exploiting bacteria for cancer immunotherapy

Bacteria-cancer interactions: bacteria-based cancer therapy

Enhanced resolution and sensitivity acoustic-resolution photoacoustic microscopy with semi/unsupervised GANs

Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and ¹⁸F-FDG PET/CT

Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase

New paradigm for tumor theranostic methodology using bacteria-based microrobot

Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines

High platelet reactivity strongly predicts early stent thrombosis in patients with drug-eluting stent implantation

Association of muscle and visceral adipose tissues with the probability of Alzheimer’s disease in healthy subjects

Enhancement of antitumor effect using dendritic cells activated with natural killer cells in the presence of Toll-like receptor agonist

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