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Using lattice-driven gating, a copper-based zeolitic imidazolate framework (Cu-ZIF-gis) with ultra-narrow 2.4 Å channels demonstrates efficient hydrogen isotope separation at high temperatures (above 120 K). This innovation leverages temperature-induced aperture adjustments to achieve sustainable and energy-efficient isotope separation, which is suitable for integration with existing LNG cryogenic infrastructure.

Atomic structural changes in nanocrystals are still poorly understood. Here, the authors introduce time-resolved Brownian tomography to directly detect 3D atomic changes in Pt nanocrystals during oxidative etching and reveal disorder at sizes of ≈1 nm.

Ultrathin amorphous carbon nitride (aCN) films are synthesized on silicon (Si) using a two-step chemical vapour deposition process, achieving uniformity, ultralow roughness and strong N–Si bonds. The resulting aCN/Si photodiodes exhibit high rectification, fast responses and broad-spectrum imaging capabilities.

Hydrofunctionalization of α-olefins with mineral acids usually proceeds with Markovnikov selectivity. Now, a strategy based on synergistic phase transfer and photoredox catalysis is developed to facilitate anti-Markovnikov addition of aqueous hydrochloric and nitric acid to unactivated alkenes.

Metal-thiolate complexes are the precursors to atomically precise metal nanoclusters. Here, the authors show that the extent of metal-ligand interaction is key to controlling the size and uniformity in the synthesis of metal nanoclusters.

Kim et al. report a strategy to reduce the dynamic disorder of the perovskite lattice by using CMMs that adsorb on the surface of PeNCs via van der Waals interactions and hydrogen bonding. The resulting pure green LEDs satisfying the Rec. 2020 color standard show a high EQE of 26.1%.

The MARTX toxins secreted by clinical V. vulnificus strains release the DUF1-RID effector duet in infected host cells. Here, the authors show that the duet hijacks calmodulin and Rac1, respectively, and transforms into a potent weapon to promote sepsis.

The PI3K/AKT signaling pathway is carefully regulated in specific cellular compartments. Lee and colleagues show that the housekeeping gene glutamyl-prolyl-tRNA synthetase 1 coordinates early endosome-specific AKT signaling necessary for inflammation resolution.

A bottleneck in solid-state batteries is the solid electrode-electrolyte interface being maintained over repeated cycles. Here, the authors use an epitaxial model system to probe and control the interface in real time.

Translationally controlled tumor protein (TCTP) regulates several cellular processes, including apoptosis, and is overexpressed in several cancer types. Here, the authors report that high levels of TCTP are associated with poor response to anti-PD-L1 and that TCTP targeting increases the efficacy of T cell-mediated anti-tumor therapy.

The authors use resonant wireless power transfer to remotely trap and release nanoparticles in solution and detect their presence as a shift in impedance in real-time. This is accomplished using the extreme field confinement of a nanogap capacitor.

A clock distribution network (CDN) is a ubiquitous element that provides synchronized clocks to all circuit blocks in the chip. Here the authors demonstrate femtosecond-precision distribution of clocks in CMOS chips using optical frequency combs and driverless CDNs.

Multiple alternating layers of two-dimensional materials and epilayers are grown on III–N and III–V substrates in a single growth run. Then, each epilayer is harvested by mechanical exfoliation, producing multiple freestanding membranes from a single wafer.

The initiation of translation is a highly regulated process that contributes to specific gene expression programs. Here the authors find that, in vertebrate, threonyl-tRNA synthetase (TRS) can act as a scaffold for the initiation machinery to stimulate the translation of a specific set of mRNAs.

The protein thioredoxin regulates the activity of many signalling molecules. Here, Hwang et al.report structural and biochemical evidence that the interaction between thioredoxin and its inhibitor thioredoxin-interacting protein is regulated by a redox-dependent disulphide bond-switching mechanism.

Nickel-rich layered oxides, such as NCM622, are promising cathode materials for lithium batteries, but chemo-mechanical failures hinder their practical application. Now the solid-state synthesis of NCM622 has been studied using multiscale in situ techniques, and kinetic competition between precursor decomposition and lithiation has been observed to lead to spatially heterogeneous intermediates and the formation of defects that are detrimental to cycling.

Due to the low ring strain and facile dimerization, ring-opening metathesis polymerization of cyclopentadiene, readily obtainable from petroleum feedstock, has not been realized. Here the authors show an ultrarapidly initiating trifluoromethanesulfonamide-based ruthenium catalyst enables it at low temperatures.

tRNA synthetases are essential to protein synthesis. Kim and colleagues identify a non-translational function for glutamyl-prolyl-tRNA synthetase during viral infection that promotes the anti-viral activity of the antiviral signaling protein MAVS.

Inorganic nanowires composed of gold(I) cyanide can be grown directly on pristine graphene, aligning themselves with the zigzag lattice directions of the graphene, and then used as templates to create graphene nanoribbons with zigzag-edged directions.

In-situ cryo-electron microscopy in thin amorphous ice films and ice-dynamics simulations reveal polymorph-dependent growth kinetics of nanoscale ice crystals. Hetero-crystalline ice exhibits anisotropic growth: fast-growing facets are associated with low-density interfaces, driving tetrahedral ordering of interfacial H₂O molecules and accelerating ice growth.

Understanding the structural changes in disordered non-equilibrium materials is important for their processing, yet it remains experimentally challenging to follow the dynamics. Here, Choe et al. image the first-order like transition from crystal to liquid in a model molecular system adsorbed on graphene by tracking individual molecules in real time.

A metastable palladium hydride is synthesized where the unique environment in the liquid cell, namely the limited quantity of Pd precursors and the continuous supply of H, resulted in the formation of the hcp phase.

Restoration of p53 activity is a promising chemotherapeutic approach, and because of the high binding affinity between HAUSP, MDM2 and p53, blocking HAUSP activity should have the net effect of robust p53 stabilization. HAUSP is inhibited by belt-like binding of vIRF4 from Kaposi's sarcoma–associated herpesvirus. Two peptides derived from vIRF4 can additively inhibit HAUSP, leading to p53-dependent cell cycle arrest and xenograft tumor regression.

Using a femtosecond mode-locked laser and a frequency-locked electric signal, a displacement measurement method that offers a >MHz measurement speed, sub-nanometre precision and a measurement range of more than several millimetres is achieved, facilitating the study of broadband, transient and nonlinear mechanical dynamics in real time.

Colloidal nanocrystals find applications from electronics to catalysis and biological sensors, but their complex surface structures are challenging to explore. Here, the authors use graphene liquid cell transmission electron microscopy to show that solubilized platinum crystals of less than 3 nm in size have individual, ordered cores surrounded by mobile surface atoms.