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Showing 1–5 of 5 results
Advanced filters: Author: Justin Delano Clear advanced filters

  • Fluorescence resonance energy transfer (FRET) between a small-molecule fluorophore donor and a transition metal ion acceptor, a method called 'transition metal ion FRET,' works over shorter distances than the classical FRET approach and can thus be used to monitor very small conformational changes in proteins.

    • Justin W Taraska
    • Michael C Puljung
    • William N Zagotta
    Research
    Nature Methods
    Volume: 6, P: 532-537

  • Polycomb group proteins are involved in the epigenetic maintenance of repressive chromatin states, with the gene-silencing activity of the Polycomb repressive complex 2 (PRC2) dependent on its ability to trimethylate lysine 27 of histone H3. The carboxy-terminal ___domain of the EED subunit of the complex is now shown to specifically bind to histone tails carrying trimethyl-lysine residues associated with repressive chromatin marks, leading to activation of the methyltransferase activity of PRC2.

    • Raphael Margueron
    • Neil Justin
    • Steven J. Gamblin
    Research
    Nature
    Volume: 461, P: 762-767

  • Redesign of the I-MsoI endonuclease binds and cleaves the new recognition site ∼10,000-fold more effectively than does the wild-type enzyme, with a level of target discrimination comparable to the original endonuclease.

    • Justin Ashworth
    • James J. Havranek
    • David Baker
    Research
    Nature
    Volume: 441, P: 656-659

  • Malaria parasites reside in vacuoles during intracellular infection of erythrocytes and export many proteins into the host cell, a process that is essential for the virulence and viability of Plasmodium. Whereas transport across the parasite membrane is known to rely on the secretory pathway, the transporter responsible for the translocation of proteins across the vacuole membrane is now identified.

    • Tania F. de Koning-Ward
    • Paul R. Gilson
    • Brendan S. Crabb
    Research
    Nature
    Volume: 459, P: 945-949