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Showing 1–2 of 2 results
Advanced filters: Author: Jyothi Parvathareddy Clear advanced filters

  • Three covalent hybrid inhibitors of SARS-CoV-2 main protease (Mpro) have been designed and compared to Pfizer’s nirmatrelvir (PF-07321332), providing atomic and thermodynamic details of their binding to the enzyme, and antiviral potency.

    • Daniel W. Kneller
    • Hui Li
    • Andrey Kovalevsky
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • The development of direct-acting antivirals to combat COVID-19 remains an important goal. Here the authors design covalent inhibitors that target the papain-like protease from SARS-CoV-2. The most promising inhibitor blocks viral replication in mammalian cells.

    • Brian C. Sanders
    • Suman Pokhrel
    • Jerry M. Parks
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17